pH News and Research

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pH comes from the term “power of Hydrogen”, or the hydrogen ion concentration present in a given solution. It helps to measure the acidity or alkalinity of a substance.

Synthetic DNA vaccine targets proteins overexpressed in several types of cancer

Scientists at The Wistar Institute have implemented a novel structurally designed synthetic DNA vaccine to simultaneously target multiple members of a family of proteins that are specifically overexpressed in several types of cancer.

28 Sep 2018

High levels of fibroblast growth factor 23 may affect brain health

Scientists at the Medical University of South Carolina have uncovered mechanisms by which high levels of a hormone called FGF23 can reduce brain health.

28 Sep 2018

New combination therapy shows potential in treating incurable HPV-related cancers

A tumor-specific vaccine combined with an immune checkpoint inhibitor shrank tumors in one third of patients with incurable cancer related to the human papilloma virus (HPV) in a phase II clinical trial led by investigators at The University of Texas MD Anderson Cancer Center and reported in JAMA Oncology.

28 Sep 2018

Genetic score helps predict future major coronary events, shows study

Coronary artery disease (CAD) is the leading killer of people with type 2 diabetes, and it's not a secret killer.

28 Sep 2018

UA professor receives NSF grant to study role of stromal cells in breast cancer

Hossein Tavana, Ph.D., an associate professor of biomedical engineering at The University of Akron (UA), has received a single-PI grant in the amount of $328,426 from the National Science Foundation - his third federal grant this year - to study the role of stromal cells in cancer.

28 Sep 2018

Food scientists can employ bacteriophage to destroy E. coli in drinking water

To rapidly detect the presence of E. coli in drinking water, Cornell University food scientists now can employ a bacteriophage - a genetically engineered virus - in a test used in hard-to-reach areas around the world.

28 Sep 2018

Critical illness and major infection can promote brain changes, accelerate cognitive decline

Researchers at Johns Hopkins report that a novel analysis of more than a thousand patients adds to evidence that hospitalization, critical illness and major infection may diminish brain structures that are most commonly affected by Alzheimer's disease.

28 Sep 2018

Daily exercise facilitates elimination of toxic proteins from muscles

A study published in Scientific Reports by researchers at the University of São Paulo in Brazil, in partnership with colleagues in the United States and Norway, shows that the lack of muscle stimulus results in a buildup of inadequately processed proteins in muscle cells and consequently leads to muscle weakness or wasting.

27 Sep 2018

Non-small cell lung cancer patients survive longer when treated with durvalumab

Non-small cell lung cancer patients survive longer when their treatment includes durvalumab following platinum-based chemoradiotherapy, according to research led by Moffitt Cancer Center.

27 Sep 2018

Simple way to measure abdominal obesity index

In obesity research, the body mass index has been traditionally used to determine if an individual is normal weight, underweight, overweight or obese. However, BMI does not differentiate between the types of the mass (fat or muscle) or body shapes.

27 Sep 2018

Cidara initiates Phase 3 clinical trial to evaluate efficacy, safety of rezafungin to treat invasive candidiasis

Cidara Therapeutics, Inc., a biotechnology company developing novel anti-infectives including immunotherapies, today announced that the first trial site has been activated for ReSTORE, a Phase 3 clinical trial evaluating the efficacy and safety of the company's lead antifungal, rezafungin, to treat candidemia and invasive candidiasis.

27 Sep 2018

FLX Bio treats first patient in its Phase 1/2 clinical trial of FLX475 for treating various advanced cancers

FLX Bio, Inc., a clinical-stage, biopharmaceutical company focused on the development of oral small-molecule drugs that target drivers of cancer and other immune-related disorders, today announced that the first patient has been treated in its Phase 1/2 clinical trial of FLX475 in patients with various advanced cancers. FLX475 is an oral, small molecule CCR4 antagonist that selectively inhibits migration of regulatory T cells into the tumor microenvironment.

27 Sep 2018

CytoSen receives favorable response from FDA to its pre-IND meeting package for CSTD002-NK

CytoSen Therapeutics, a private biopharmaceutical company accelerating innovation in Natural Killer cell therapy, today announced it has received a favorable response from the U.S. Food and Drug Administration to its pre-Investigational New Drug meeting package for the proposed Phase 2 trial of CytoSen's adoptive NK cell therapy, CSTD002-NK, for the reduction of relapse in high risk acute myeloid leukemia or myelodysplastic syndrome in patients undergoing haploidentical hematopoietic stem cell transplantation.

27 Sep 2018

Alnylam announces positive results from Phase 3 Study of givosiran for treating acute hepatic porphyria

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today positive topline results from the interim analysis of the ENVISION Phase 3 Study of givosiran, an investigational RNAi therapeutic targeting aminolevulinic acid synthase 1 for the treatment of acute hepatic porphyria.

27 Sep 2018

Decibel obtains exclusive license to commercialize ORC-13661 for preventing hearing, balance disorders

Decibel Therapeutics and Oricula Therapeutics today announced that Decibel has obtained an exclusive, worldwide license to the development and commercialization of ORC-13661, an oral medication developed by Oricula Therapeutics for the prevention of hearing loss and balance disorders that can occur following treatment of severe infections with aminoglycoside antibiotics.

27 Sep 2018

New book provides evidence that new drugs, medical technologies are safe and effective

Does a new medicine or diagnostic test work? Is it safe? Should the government approve it and insurers pay for it? The answers are not as straightforward as they may seem - and the reasons are the subject of a new book by Karen J. Maschke, a research scholar at The Hastings Center, and Michael K. Gusmano, a Hastings Center research scholar and an associate professor of health policy at Rutgers University School of Public Health.

27 Sep 2018

VCU researchers to study how a gene could influence cognitive decline during chemotherapy

With the help of a $2.1 million grant, Virginia Commonwealth University School of Nursing researchers will study how a gene that regulates estrogen and neurotransmitter levels could be tied to cognitive decline in patients undergoing chemotherapy for breast and endometrial cancers.

27 Sep 2018

pH News and Research

Further Reading

Synthetic DNA vaccine targets proteins overexpressed in several types of cancer

High levels of fibroblast growth factor 23 may affect brain health

New combination therapy shows potential in treating incurable HPV-related cancers

Genetic score helps predict future major coronary events, shows study

UA professor receives NSF grant to study role of stromal cells in breast cancer

Food scientists can employ bacteriophage to destroy E. coli in drinking water

Critical illness and major infection can promote brain changes, accelerate cognitive decline

Daily exercise facilitates elimination of toxic proteins from muscles

Non-small cell lung cancer patients survive longer when treated with durvalumab

Simple way to measure abdominal obesity index

Cidara initiates Phase 3 clinical trial to evaluate efficacy, safety of rezafungin to treat invasive candidiasis

FLX Bio treats first patient in its Phase 1/2 clinical trial of FLX475 for treating various advanced cancers

CytoSen receives favorable response from FDA to its pre-IND meeting package for CSTD002-NK

Alnylam announces positive results from Phase 3 Study of givosiran for treating acute hepatic porphyria

Decibel obtains exclusive license to commercialize ORC-13661 for preventing hearing, balance disorders

New book provides evidence that new drugs, medical technologies are safe and effective

VCU researchers to study how a gene could influence cognitive decline during chemotherapy

Moffitt researcher awarded World Molecular Imaging Society's highest honor

Mapping the trillion cells in the human body

Protective gel sphere may offer probiotics a safer route to the intestines

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