Carcinoma News and Research

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Carcinoma is cancer that begins in the skin or in tissues that line or cover internal organs.

Identifying genomic subtypes of pancreatic cancer from histology slides using AI-based tool

AP-HP Greater Paris University Hospitals, the leading European clinical trial center with the largest amount of healthcare data in France dedicated to research and Owkin, a startup pioneering Federated Learning and AI technologies for medical research and clinical development, announced the recent results of their ongoing strategic collaboration at ASCO 2021.

10 Jun 2021

New study could help guide oncologists in selecting the best treatment for kidney cancers

Not all kidney cancers behave the same, with wildly different responses to immunotherapy or other treatments – and wildly different outcomes for patients as a result.

8 Jun 2021

Drug sensitivity of hepatocellular cancer cells may provide new insights on tumor biology

Oncotarget published "Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells" which reported that this study aimed to investigate whether Hepatocellular Cancer (HCC) cells cultured in more native conditions have an altered phenotype and drug sensitivity compared to those cultured in standard conditions.

8 Jun 2021

Lymphangiogenesis predicts favorable outcomes to immunotherapy

Oncotarget published "Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma" which reported that although tumor-associated lymphangiogenesis correlates with metastasis and poor prognosis in several cancers, it also supports T cell infiltration into the tumor and predicts favorable outcome to immunotherapy.

8 Jun 2021

Weight loss drug Wegovy approved by FDA

The U.S. Food and Drug Administration (FDA) has approved Wegovy (semaglutide) injection (2.4 mg once weekly) as a chronic weight management treatment in obese or overweight adults with a weight-related condition (such as high blood pressure, type 2 diabetes, or high cholesterol), when used along with calorie restriction and physical activity. Wegovy, is a more potent version of Novo Nordisk's diabetes drug semaglutide.

4 Jun 2021

SARS-CoV-2 evades neutralizing antibodies and rapidly spreads by cell fusion, finds study

In a new study by researchers in the UK, Germany and South Africa, this process is visualized using time-lapse microscopy of a human cell lung line, demonstrating that SARS-CoV-2 can induce cell-to-cell fusion within 6 hours post-infection. Further, the application of neutralizing monoclonal antibodies or convalescent plasma was unable to prevent the spread of the virus by this mechanism, suggesting that removing SARS-CoV-2 from cells permissive of cell membrane fusion could be more difficult than other types of cell.

4 Jun 2021

Study: Lung squamous patients harboring druggable mutations have lower median overall survival

Oncotarget published "Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations" which reported that unlike lung adenocarcinoma patients, there is no FDA-approved targeted-therapy likely to benefit lung squamous cell carcinoma patients.

3 Jun 2021

E6-specific inhibitors offer a unique, strategic approach for treating HPV-HNSCC

Oncotarget published "A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV+ head and neck squamous cell carcinomas" which reported that the incidence of human papillomavirus-positive head and neck squamous cell carcinoma has increased dramatically over the past decades due to an increase in infection of the oral mucosa by HPV.

3 Jun 2021

Nanopore sequencing contradicts human genome integration of SARS-CoV-2

Now a new preprint research paper posted to the bioRxiv* server dismisses the possibility, raised by that study, that the virus inserts its genetic material into the host cell’s genome.

2 Jun 2021

Molecular subtype of cancer preferentially affects people with Indigenous ancestry

Oncotarget published "Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry" which reported that contrasting with this pattern, the age structure of HCC in Andean people displays a bimodal distribution with half of the patients developing HCC in adolescence and early adulthood.

2 Jun 2021

Glucosidase inhibitors hold promise as novel therapeutic agents against SARS-CoV-2

In a new study posted to the bioRxiv* preprint server, researchers from the United States report that two iminosugar glucosidase inhibitors have the ability to suppress the replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in tissue culture – at concentrations of at least 100 times lower than required for cytotoxic effects.

19 May 2021

UCL scientists identify new immunotherapy to combat hepatitis B virus

Scientists at UCL have identified a new immunotherapy to combat the hepatitis B virus (HBV), the most common cause of liver cancer in the world.

14 May 2021

New class of anti-cancer compounds effectively kills liver and breast cancer cells

A team of Oregon State University scientists has discovered a new class of anti-cancer compounds that effectively kill liver and breast cancer cells.

12 May 2021

Esophageal cancers turn on ancient viral DNA hidden in our genome

Scientists have discovered that many esophageal cancers turn on ancient viral DNA that was embedded in our genome hundreds of millions of years ago.

10 May 2021

Advanced-stage kidney cancer more common in Hispanic and Native Americans in Arizona

Recently published research from the University of Arizona Health Sciences shows that advanced-stage kidney cancer is more common in Hispanic Americans and Native Americans than in non-Hispanic whites, and that both Hispanic Americans and Native Americans in Arizona have an increased risk of mortality from the disease.

6 May 2021

New study launched to more accurately diagnose early hepatocellular carcinoma

A first of its kind cohort study on patients at high risk of developing primary liver cancer also known as hepatocellular carcinoma (HCC), has been launched to diagnose HCC more accurately at an earlier stage and to predict an individual's likelihood of developing the cancer.

3 May 2021

New book provides details on the roles of inflammation in head and neck malignancy

'Head and Neck Cancer: Hallmarks of The Inflammation Ecosystem' aims to highlight the significant roles of inflammation in head and neck malignancy.

29 Apr 2021

FDA issues noncompliance notice for failing to submit clinical trial summary results to ClinicalTrials.gov

Being transparent about the results of completed clinical trials enables important advances in the development of medical products and helps ensure a safe, effective and efficient clinical research enterprise.

28 Apr 2021

Topical therapy can help safely reduce side effect of cancer treatment

Patients with advanced colorectal cancer may be spared from a toxic side effect caused by a type of targeted therapy used to treat the cancer with the help of another drug normally used to treat melanoma, according to a study led by researchers at the UCLA Jonsson Comprehensive Cancer Center and Memorial Sloan Kettering Cancer Center.

28 Apr 2021

Menopausal symptoms in breast cancer patients could be reduced through CBT delivered by nurses

Menopausal symptoms - hot flushes and night sweats – experienced by women with breast cancer can be reduced through group cognitive behavioral therapy (CBT) delivered by breast care nurses, a new clinical trial reveals.

27 Apr 2021

Carcinoma News and Research

Further Reading

Identifying genomic subtypes of pancreatic cancer from histology slides using AI-based tool

New study could help guide oncologists in selecting the best treatment for kidney cancers

Drug sensitivity of hepatocellular cancer cells may provide new insights on tumor biology

Lymphangiogenesis predicts favorable outcomes to immunotherapy

Weight loss drug Wegovy approved by FDA

SARS-CoV-2 evades neutralizing antibodies and rapidly spreads by cell fusion, finds study

Study: Lung squamous patients harboring druggable mutations have lower median overall survival

E6-specific inhibitors offer a unique, strategic approach for treating HPV-HNSCC

Nanopore sequencing contradicts human genome integration of SARS-CoV-2

Molecular subtype of cancer preferentially affects people with Indigenous ancestry

Glucosidase inhibitors hold promise as novel therapeutic agents against SARS-CoV-2

UCL scientists identify new immunotherapy to combat hepatitis B virus

New class of anti-cancer compounds effectively kills liver and breast cancer cells

Esophageal cancers turn on ancient viral DNA hidden in our genome

Advanced-stage kidney cancer more common in Hispanic and Native Americans in Arizona

New study launched to more accurately diagnose early hepatocellular carcinoma

New book provides details on the roles of inflammation in head and neck malignancy

FDA issues noncompliance notice for failing to submit clinical trial summary results to ClinicalTrials.gov

Topical therapy can help safely reduce side effect of cancer treatment

Menopausal symptoms in breast cancer patients could be reduced through CBT delivered by nurses

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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