RNA Sequencing News and Research

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Genome analysis of alphacoronavirus and betacoronavirus species from South Korean bats

Researchers performed genomic comparisons between alphacoronaviruses (αCoVs) and betacoronaviruses (βCoVs) originating from South Korean Bats.

28 Jun 2022

Molecular tumor profiling in pediatric cancer patients significantly impacts clinical care

Results of a study of molecular tumor profiling in young patients revealed a high rate of genetic alterations with potential for impacting clinical care, including clarifying diagnoses and treatment with matched, precision cancer drugs.

23 Jun 2022

Researchers discover two important novel aspects of APOE4 gene in Alzheimer's patients

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia, affecting more than 5.8 million individuals in the U.S.

23 Jun 2022

Even asymptomatic maternal COVID-19 can potentially cause pregnancy complications

A recent study published in the Cell Reports journal analyzed immune ecology at the placenta in mild or asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy.

22 Jun 2022

INTEGRA solutions helping to support a new generation of RNA sequencing

INTEGRA Biosciences’ electronic handheld pipetting solutions are helping to improve the throughput capacity of bulk RNA barcoding and sequencing (BRB-seq) at Alithea Genomics in Switzerland.

From INTEGRA Biosciences 17 Jun 2022

Drug combinations may help to slow the progression of diabetic kidney disease

A mouse study led by Washington University School of Medicine in St. Louis suggests that combining SGLT2 inhibitors — a newer class of diabetes medications that lowers blood sugar — with older diabetes drugs may help to slow the progression of diabetic kidney disease.

15 Jun 2022

Even mild respiratory COVID can affect the brain

In a recent study published in the journal Cell, researchers explored neurological symptoms and subsequent cognitive impairment experienced by survivors of mild respiratory coronavirus disease 2019 (COVID-19).

14 Jun 2022

New protocol can develop safe, efficient pluripotent stem cell-based therapies for macular degeneration

As we age, so do our eyes; most commonly, this involves changes to our vision and new glasses, but there are more severe forms of age-related eye problems.

14 Jun 2022

Innate and adaptive immune responses to SARS-CoV-2 infection in older golden hamsters

Researchers assessed the variation in SARS-CoV-2 manifestation with age.

13 Jun 2022

Whole-genome sequencing can help provide an accurate diagnosis of severely ill infants

Children who are born severely ill or who develop serious illness in the first few weeks of life are often difficult to diagnose, with considerable implications for their short and longer-term care.

13 Jun 2022

Stress protein in fibroblasts appears to be an attractive cancer drug target

A stress protein that is overactive in many types of tumor cells also has a key role in tumor-supporting cells called fibroblasts, and may be a good target for future cancer treatments, suggests a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

10 Jun 2022

Creating CAR T cells without an immune brake

T cells are usually very good at eliminating diseased cells. But they seem to fail when it comes to tumor cells.

10 Jun 2022

Researchers create first comprehensive functional map of genes expressed in human cells

The Human Genome Project was an ambitious initiative to sequence every piece of human DNA. The project drew together collaborators from research institutions around the world, including Whitehead Institute, and was finally completed in 2003.

9 Jun 2022

Insilico Medicine plans to launch a fully automated AI-driven robotics lab for drug discovery

Insilico Medicine's end-to-end AI-driven drug discovery platform, Pharma.AI, draws its strength from the quality and quantity of its data. As Insilico scientific advisory board member and Nobel Prize laureate in chemistry Dr. Michael Levitt has said, Insilico's platform capitalizes on the ability of artificial intelligence to take vast amounts of data from many different components and find patterns and make predictions that can point the way to new life-saving medications.

9 Jun 2022

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

In a recent study posted to the bioRxiv* pre-print server, researchers examined how the interaction of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) open reading frame 8 (ORF8) protein with host dendritic cells (DCs) induced cytokine storm.

8 Jun 2022

Targeting thalamic circuits could reverse Parkinson’s symptoms in mice

Parkinson's disease is best-known as a disorder of movement. Patients often experience tremors, loss of balance, and difficulty initiating movement. The disease also has lesser-known symptoms that are nonmotor, including depression.

8 Jun 2022

Newly identified coronavirus seems to be well established in Sweden's red-backed voles

Researchers from the Zoonosis Science Center at Uppsala University have identified a new coronavirus. Their study of approximately 260 bank voles caught around Grimsö, örebro County, shows that the virus is well established in Sweden's red-backed voles. The finding has been published in the journal Viruses.

8 Jun 2022

Discovery may lead to new treatments to reduce inflammation in vitiligo disease

A new study, led by researchers from the University of California, Irvine, reveals the unique cell-to-cell communication networks that can perpetuate inflammation and prevent repigmentation in patients with vitiligo disease.

7 Jun 2022

Computer vision tool effectively distinguishes rheumatoid arthritis from osteoarthritis in joint tissue

A new study led by Hospital for Special Surgery investigators in New York City has found that their computer vision tool effectively distinguishes rheumatoid arthritis (RA) from osteoarthritis (OA) in joint tissue taken from patients who underwent total knee replacement (TKR).

3 Jun 2022

New research may open a window to treating aggressive form of B-cell acute lymphoblastic leukemia

Survival has improved greatly in children with acute lymphocytic leukemia (ALL). But a certain form of ALL that occurs mostly in babies is still very lethal, with a survival rate below 50 percent: B-cell acute lymphoblastic leukemia with rearrangements of the mixed lineage leukemia gene, or MLL B-ALL.

1 Jun 2022

RNA Sequencing News and Research

Genome analysis of alphacoronavirus and betacoronavirus species from South Korean bats

Molecular tumor profiling in pediatric cancer patients significantly impacts clinical care

Researchers discover two important novel aspects of APOE4 gene in Alzheimer's patients

Even asymptomatic maternal COVID-19 can potentially cause pregnancy complications

INTEGRA solutions helping to support a new generation of RNA sequencing

Drug combinations may help to slow the progression of diabetic kidney disease

Even mild respiratory COVID can affect the brain

New protocol can develop safe, efficient pluripotent stem cell-based therapies for macular degeneration

Innate and adaptive immune responses to SARS-CoV-2 infection in older golden hamsters

Whole-genome sequencing can help provide an accurate diagnosis of severely ill infants

Stress protein in fibroblasts appears to be an attractive cancer drug target

Creating CAR T cells without an immune brake

Researchers create first comprehensive functional map of genes expressed in human cells

Insilico Medicine plans to launch a fully automated AI-driven robotics lab for drug discovery

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

Targeting thalamic circuits could reverse Parkinson’s symptoms in mice

Newly identified coronavirus seems to be well established in Sweden's red-backed voles

Discovery may lead to new treatments to reduce inflammation in vitiligo disease

Computer vision tool effectively distinguishes rheumatoid arthritis from osteoarthritis in joint tissue

New research may open a window to treating aggressive form of B-cell acute lymphoblastic leukemia

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