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Study indicates decline in use of chemotherapy for early stage breast cancer patients

A study of nearly 3,000 women with early stage breast cancer indicates a recent, significant decline in the use of chemotherapy despite the lack of any change in national treatment recommendations or guidelines, according to researchers at the Stanford University School of Medicine and the University of Michigan.

11 Dec 2017

CAR T cell therapy shows long-lasting remissions in non-Hodgkin's lymphoma patients

In a pair of clinical trials stretching from Philadelphia to Tokyo, the chimeric antigen receptor (CAR) T cell therapy Kymriah (formerly known as CTL019) demonstrated long-lasting remissions in non-Hodgkin's lymphoma (NHL) patients.

11 Dec 2017

Two immunotherapy approaches for multiple myeloma show hope

Researchers from the University of Pennsylvania's Abramson Cancer Center have developed two experimental immunotherapy methods that include one chimeric antigen receptor (CAR) T cell therapy for the treatment of multiple myeloma patients who were not responding to other treatments.

11 Dec 2017

PARP inhibitor can be new treatment option for patients with metastatic breast cancer, BRCA mutations

In a randomized, Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, the PARP inhibitor talazoparib extended progression-free survival (PFS) and improved quality-of-life measures over available chemotherapies for patients with metastatic HER2-negative breast cancer and mutations in the BRCA1/2 genes.

8 Dec 2017

SLU scientists provide promising approach in designing new drugs for DMD

In a paper published in the Nature journal Scientific Reports, Saint Louis University researchers report that a new drug reduces fibrosis (scarring) and prevents loss of muscle function in an animal model of Duchenne muscular dystrophy (DMD), providing a promising approach in designing new medications for those suffering from DMD.

8 Dec 2017

University of Adelaide receives $23.2 million for preterm birth research

The University of Adelaide has been awarded $23.2 million for new research tackling some of the world's most significant health problems, including one of the biggest killers of children: preterm birth.

8 Dec 2017

New first line combination therapy shows promising results in patients with advanced NSCLC

A new combination therapy for the first line treatment of advanced non-squamous non-small-cell lung cancer (NSCLC) improves progression-free survival (PFS), according to results of phase III IMpower150 trial presented at the ESMO Immuno Oncology Congress 2017.

7 Dec 2017

Brazilian researchers identify genes linked to melanoma progression

When researchers at the University of São Paulo in Brazil treated human melanoma cell lines with a synthetic compound similar to curcumin, one of the pigments that give turmeric its orange color, they identified genes with altered expression in potentially invasive tumors and malignant cells resistant to chemotherapy.

6 Dec 2017

Bioelectronic 'nose' can easily sniff foul smells in rotting food

Strong odors are an indicator that food has gone bad, but there could soon be a new way to sniff foul smells earlier on.

6 Dec 2017

Researchers unravel novel mechanism of estrogen action on heart physiology

Estrogens are powerful hormones important for the formation and function of the nervous, reproductive and cardiovascular systems.

6 Dec 2017

Reducing mitochondrial protein in cardiac muscle cells initiates heart failure

Reducing a protein found in the mitochondria of cardiac muscle cells initiates cardiac dysfunction and heart failure, a finding that could provide insight for new treatments for cardiovascular diseases, a study led by Georgia State University has shown.

6 Dec 2017

UT Southwestern researchers identify potential approach to suppress lethal parasitic infections

UT Southwestern Medical Center researchers have identified a chemical that suppresses the lethal form of a parasitic infection caused by roundworms that affects up to 100 million people and usually causes only mild symptoms.

5 Dec 2017

Biological Applications of AFM

An interview with Samuel Lesko, European Applications Manager, Bruker Nano Surfaces conducted by April Cashin-Garbutt, MA (Cantab).

From Bruker Nano Surfaces and Metrology 5 Dec 2017

New treatment aims to target abnormally shaped protein in deadly childhood brain cancer

Children with an extremely deadly form of brain cancer might benefit from a new treatment that aims to direct an immune response against an abnormally shaped protein found exclusively on cancer cells, according to a new study led by UC San Francisco researchers.

4 Dec 2017

Research could contribute to development of therapeutic drug and vaccine against malaria

Malaria is one of three major infectious diseases affecting approximately 300 million people every year, accounting for about 500,000 deaths, but effective vaccine development has not been successful.

4 Dec 2017

Study identifies new role for stress receptor CRF1 expressed on mast cells

A new study published online in the Journal of Leukocyte Biology provides new insight into how stress, through signaling of corticotropin-releasing factor (CRF), interacts with cells in the immune system to cause disease.

1 Dec 2017

Study provides insights on mechanisms involved in tolerance after kidney transplantation

A new study provides insights on the mechanisms that allow an individual's immune system to accept, rather than reject, a donor kidney. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology, point to markers that could be monitored to assess and track the health of organs following transplantation.

1 Dec 2017

Receptor News and Research

Study indicates decline in use of chemotherapy for early stage breast cancer patients

CAR T cell therapy shows long-lasting remissions in non-Hodgkin's lymphoma patients

Two immunotherapy approaches for multiple myeloma show hope

PARP inhibitor can be new treatment option for patients with metastatic breast cancer, BRCA mutations

SLU scientists provide promising approach in designing new drugs for DMD

University of Adelaide receives $23.2 million for preterm birth research

New first line combination therapy shows promising results in patients with advanced NSCLC

Brazilian researchers identify genes linked to melanoma progression

Bioelectronic 'nose' can easily sniff foul smells in rotting food

Researchers unravel novel mechanism of estrogen action on heart physiology

Reducing mitochondrial protein in cardiac muscle cells initiates heart failure

UT Southwestern researchers identify potential approach to suppress lethal parasitic infections

Biological Applications of AFM

New treatment aims to target abnormally shaped protein in deadly childhood brain cancer

Research could contribute to development of therapeutic drug and vaccine against malaria

Study identifies new role for stress receptor CRF1 expressed on mast cells

Study provides insights on mechanisms involved in tolerance after kidney transplantation

Researchers identify vulnerability for glioblastoma subtypes

UNIGE scientists unravel key role played by the liver in onset of type-2 diabetes

Invasive cells deploy a trick to squeeze through barriers

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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