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Biogen to pursue FDA regulatory approval for investigational drug aducanumab

On behalf of the more than 5 million Americans living with Alzheimer's and their family members, the Alzheimer's Association is encouraged to learn that Biogen will pursue regulatory approval from the FDA for the investigational drug aducanumab based on Phase 3 clinical trial results from the EMERGE and ENGAGE studies, and other related data, after finding a reduction of cognitive and functional decline in people taking the high dose.

22 Oct 2019

Study dispels the hypothesis that metformin could help exercising seniors gain more muscle mass

A clinical trial initiated by University of Kentucky researchers argues against the hypothesis that the diabetes drug metformin could help exercising seniors gain more muscle mass. The double-blind trial, conducted at the University of Kentucky and University of Alabama at Birmingham, found that older adults who took metformin while performing rigorous resistance exercise training had smaller gains in muscle mass than the placebo group.

22 Oct 2019

Research introduces a revolutionary treatment for infections

Titanium has many properties that make it a great choice for use in implants. Its low density, high stiffness, high biomechnanical strength-to-weight ratio, and corrosion resistance have led to its use in several types of implants, from dental to joints.

22 Oct 2019

Study blunts hopes that diabetes drug could help exercising seniors gain more muscle mass

A new clinical trial dispels the hypothesis that the diabetes drug metformin could help exercising seniors gain more muscle mass.

22 Oct 2019

New treatment shows promise to reverse celiac disease

Results of a new phase 2 clinical trial using technology developed at Northwestern Medicine show it is possible to induce immune tolerance to gluten in individuals with celiac disease. The findings may pave the way for treated celiac patients to eventually tolerate gluten in their diet.

22 Oct 2019

IBD far more common than expected, and will only increase in future

There are three times as many people with the chronic and debilitating bowel disorder called inflammatory bowel disease (IBD) as ever thought before, according to a new study presented today at UEG Week 2019, at Barcelona. Not only is the condition a distressing one in itself, but patients with IBD have a higher risk of colorectal cancer as well.

21 Oct 2019

Autism spectrum disorder could be triggered by low placental steroid levels

A recent experimental study has shown that one reason for the occurrence of autism spectrum disorder (ASD) could be the deficit of a placental steroid hormone called allopregnanolone. The reason is that this hormone plays a critical role in the normal development of the brain in fetal life.

21 Oct 2019

Antibiotic resistance doubles in just two decades

Antibiotic resistance poses a grave challenge to many previously curable infectious diseases. At present, antibiotic resistance is proving to increase at a much faster rate compared to the development of new therapies.

21 Oct 2019

Healthiest gut bacteria with plant-based or Mediterranean diet

A new study shows that specific foods that are supplied by either a plant-based or a Mediterranean-type diet can protect the gut against inflammatory disorders, by selectively promoting the growth of anti-inflammatory bacteria.

21 Oct 2019

Patients with diabetes may have worse lung infections

People with diabetes are at a higher risk of various complications, including worse respiratory diseases. One of the most dreaded lung diseases is the Middle East respiratory syndrome coronavirus (MERS-CoV), which emerged in Saudi Arabia in 2012.

21 Oct 2019

Research shows brain's immune system gets activated by stress during pregnancy

Chronic stress during pregnancy triggers an immune response in the brain that has potential to alter brain functions in ways that could contribute to postpartum depression, new research in animals suggests.

21 Oct 2019

Patterns unique to the striatum observed in people with Huntington's disease

The part of the brain that selectively degenerates in people with Huntington's disease (HD), called the striatum, is almost entirely destroyed in the late stages of the disease. Brain samples from mutant HD gene positive individuals who had not yet developed symptoms by time of death are extremely rare. As a consequence, very little is known about the active disease process that causes the devastating symptoms of HD.

21 Oct 2019

SciLifeLab and AstraZeneca establish cryo-EM collaboration to advance biomedicine

The study published in Science Advances reveals the mechanism by which the receptor tyrosine kinase RET can increase neuronal survival in degenerative diseases. To understand the mechanism of this signaling complex, the researchers solved the cryo-EM structure of its extracellular region, employing a new approach for data collection.

21 Oct 2019

Neuroscientists to introduce new approach to assess brain damage in Parkinson's patients

TSU neuroscientists and their colleagues from SibSMU plan to introduce a new approach to studying brain damage in patients with Parkinson's disease

18 Oct 2019

Vaping propylene glycol and vegetable glycerine may lead to lung inflammation

Researchers have found that using e-cigarettes with the e-liquid refills containing propylene glycol (PG) and vegetable glycerine (VG) may lead to inflammation of the lungs over a period of time. The results of the study titled, “Effects of Electronic Cigarette Constituents on the Human Lung: A Pilot Clinical Trial,” was published in the latest issue of the journal Cancer Prevention Research this week.

18 Oct 2019

Being obese may lead to fat accumulation in the lungs

Obesity is a growing health concern among children and adults across the globe. In the 2016 figures from the World Health Organization (WHO), 1.9 billion adults are overweight worldwide, and of these, over 650 million were obese.

17 Oct 2019

Lyme vaccine on the horizon, says new study

Lyme disease is a dreaded disease caused by the bite of an infected tick. The only way to prevent it is by not getting bitten by the tick. However, this is not a practical recommendation, since even today about 300,000 thousand people are diagnosed with this infection, in the US alone, and over 100,000 in Europe, each year.

17 Oct 2019

Scientists report evidence of immune response targeting brain cells in autism

Autism spectrum disorders affect one in 59 American children by age eight. With no known quantitative biological features, autism diagnoses are currently based on expert assessments of behavioral symptoms, including impaired social skills and communication, repetitive behaviors and restricted interests.

17 Oct 2019

Keto diet may cause skin problems

Researchers from Austria have found that ketogenic diets could affect psoriasis-like skin inflammation in mice. They noted that keto diets including medium-chain triglycerides (MCTs) such as coconut along with omega-3 fatty acids obtained from nuts and seeds and fish oil could be a recipe for psoriasis exacerbation. They speculated that this could be true for humans as well. The study titled, “The Influence of Ketogenic Diets on Psoriasiform-Like Skin Inflammation,” was published this week in the Journal of Investigative Dermatology.

17 Oct 2019

Novel antibiotic-free approach to tackle superbugs

Scientists have uncovered a novel antibiotic-free approach that could help prevent and treat one of the most widespread bacterial pathogens, using nanocapsules made of natural ingredients.

17 Oct 2019