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RNAi screen identifies Brd4 as a therapeutic target for acute myeloid leukemia

Scientists at Cold Spring Harbor Laboratory (CSHL) and five other institutions have used an unconventional approach to cancer drug discovery to identify a new potential treatment for acute myeloid leukemia.

4 Aug 2011

UH undergraduates seek solutions to many maladies like diabetes, Alzheimer's

Students from a variety of majors are devoting their summers to serious research at the University of Houston (UH), seeking eventual solutions to many serious maladies that include Alzheimer's, high blood pressure and cholesterol, diabetes, alcoholism and anxiety.

4 Aug 2011

NIH-funded study to assess biomarkers in the blood of TBI patients

Biomarkers in the bloodstream could provide physicians with a quick and accurate method of assessing the severity of traumatic brain injury (TBI) and helping deliver and monitor the results of therapies, such as progesterone treatment.

4 Aug 2011

Knee osteoarthritis more common in women than men

A Mayo Clinic orthopedic surgeon suspects that the nagging pain and inflammation that women can experience in their knees may be different from what men encounter, and she has been chosen to lead a novel U.S.-Canadian study to explore the question.

4 Aug 2011

Nacolepsy drugs may be effective in reversing illness-induced lethargy

A signaling system in the brain previously shown to regulate sleep is also responsible for inducing lethargy during illness, according to research conducted at Oregon Health & Science University Doernbecher Children's Hospital.

4 Aug 2011

NSF awards WSU researcher CAREER grant to develop neural implants

Neural implants have the potential to treat disorders and diseases that typically require long-term treatment, such as blindness, deafness, epilepsy, spinal cord injury, and Alzheimer's and Parkinson's. However, implantable devices have been problematic in clinical applications because of bodily reactions that limit device functioning time.

4 Aug 2011

Insight into how brain organizes during development

Scientists at the Allen Institute for Brain Science have taken an important step in identifying how the brain organizes itself during development. The findings, published in the Journal of Comparative Neurology today, describe - in more detail than ever before - the consequences of the loss of a key molecule involved in establishing proper brain architecture during brain development.

3 Aug 2011

Lifestyle factors of people with exceptional longevity

People who live to 95 or older are no more virtuous than the rest of us in terms of their diet, exercise routine or smoking and drinking habits, according to researchers at Albert Einstein College of Medicine of Yeshiva University.

3 Aug 2011

Post-traumatic stress disorder drug risperidone not working: Study

According to a new study a medication commonly used to treat post-traumatic stress disorder in combat veterans may not be effective in reducing overall PTSD severity.

3 Aug 2011

Smoking, high blood pressure and diabetes in middle age linked to brain damage

A new study suggests smoking, high blood pressure, diabetes and being overweight in middle age may cause brain shrinkage and lead to cognitive problems up to a decade later.

2 Aug 2011

Prison research to examine neural circuitry of criminal psychopaths

A leading University of Chicago researcher on empathy is launching a project to understand psychopathy by studying criminals in prisons.

2 Aug 2011

AstraZeneca recruits patients for KODIAC Phase III trial in opioid-induced constipation

AstraZeneca today announced that study centers across the U.S. are recruiting patients for a clinical study to examine whether an investigational drug is safe and effective in treating opioid-induced constipation.

2 Aug 2011

Statins may help protect young people from future strokes

New research indicates cholesterol lowering drugs known as statins may help prevent future strokes among young people who have already had a stroke.

2 Aug 2011

Myb protein suppression can help eliminate acute myelogenous leukemia

A team of scientists at Cold Spring Harbor Laboratory (CSHL) has laid bare the mechanism behind a phenomenon called oncogene addiction in mice suffering from a form of leukemia that mimics acute myelogenous leukemia (AML) in humans.

1 Aug 2011

8 out of ten Australians would use genetic depression susceptibility test results to reduce risky behaviour, survey shows

Eight out of ten Australians would radically change their behaviour if tests showed they had a genetic susceptibility to depression, a national study has found.

31 Jul 2011

New software tools for fast, accurate reconstruction of neural networks

The human brain is the most complex of all organs, containing billions of neurons with their corresponding projections, all woven together in a highly complex, three-dimensional web. To date, mapping this vast network posed a practically insurmountable challenge to scientists.

30 Jul 2011

New fluorescent tool can track mysterious workings of cellular RNAs

The ability to tag proteins with a green fluorescent light to watch how they behave inside cells so revolutionized the understanding of protein biology that it earned the scientific teams who developed the technique Nobel Prizes in 2008.

30 Jul 2011

Individuals with dyslexia do not experience familiar language advantage

When people recognize voices, part of what helps make voice recognition accurate is noticing how people pronounce words differently. But individuals with dyslexia don't experience this familiar language advantage, say researchers.

30 Jul 2011

UH Rainbow physicians to participate in two new clinical trials with AsthmaNet

Physicians at University Hospitals (UH) Rainbow Babies and Children's Hospital are participating in two new clinical trials with the national research consortium AsthmaNet.

30 Jul 2011

FDA issues Refusal to File letter for Eisai's perampanel NDA to treat partial-onset seizures

Eisai Inc. announced today that the U.S. Food and Drug Administration (FDA) has issued a Refusal to File letter in response to the company's New Drug Application (NDA) for perampanel (E2007), an investigational drug, for the treatment of partial-onset seizures associated with epilepsy which was submitted in May 2011.

29 Jul 2011