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Fatty acid-derived bioactive molecule helps improve heart function after heart attack in mice

Heart attacks provoke an acute immune response. Leukocytes rush to the heart muscle to remove dead cells and begin building scar tissue. This is followed by a second immune response, the resolving phase that allows healing.

7 Sep 2017

BUSM researchers show new way to reduce skin cancer risk in redheads

Red-haired people are known for pale skin, freckles, poor tanning ability and unfortunately, an increased risk for developing skin cancer.

6 Sep 2017

Researchers investigate link between thyroid hormone and red blood cell production

For more than a century, physicians have anecdotally noted that patients with an underactive thyroid - often caused by iodine deficiency - tended to also have anemia. But the link between thyroid hormone and red blood cell production has remained elusive.

6 Sep 2017

Heparin promotes food intake and body weight gain in animal models

Heparin is a medication widely used to prevent blood clotting; it is named after and mimics the naturally occurring anticoagulant in the body.

6 Sep 2017

High levels of suPAR protein shown to be likely cause of kidney damage in children

High levels of a protein known as suPAR, which has been shown to be a marker and likely cause of kidney damage, is as reliably predictive in children as in adults, according to results of a study published online today in JAMA Pediatrics, a clinical publication of the American Medical Association.

5 Sep 2017

Novel, ultra-rare damaging genetic variants may contribute to eating disorders

By combining whole exome sequencing, machine learning, and network analysis, researchers have identified new, ultra-rare gene mutations within specific biological pathways that may contribute to eating disorders.

5 Sep 2017

Scientists show how receptors for drugs act inside cells

G protein-coupled receptors are the key target of a large number of drugs. Würzburg scientists have now been able to show more precisely how these receptors act in the cell interior.

5 Sep 2017

Better understanding of serotonin's function in the brain could lead to radical shift in psychiatric care

A better understanding of how a key chemical messenger acts in the brain could lead to a radical shift in psychiatric care, according to a new research paper.

4 Sep 2017

Long-term alcohol use changes brain functions differently in young men and women

Scientists have found that brain functions in young men and women are changed by long-term alcohol use, but that these changes are significantly different in men and women.

4 Sep 2017

New study offers insights on mechanisms behind development of kidney damage due to obesity

A new study provides insights on the mechanisms behind the development of kidney damage due to obesity. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology, point to a potential target for protecting the kidney health of individuals with obesity.

1 Sep 2017

Common heart disease medication may help treat pulmonary arterial hypertension

A team of Cleveland Clinic researchers found that a common heart disease medication, beta blockers, may help treat pulmonary arterial hypertension (PAH), a debilitating lung disease.

31 Aug 2017

Beta blockers capable of reducing stress signaling may enhance effectiveness of immunotherapy

While the development of therapies designed to block "checkpoints" within the immune system has been one of the most exciting and noteworthy advances in cancer research in recent years, it's also been one of the most puzzling, leaving researchers to ask: Why don't these new therapies work for more patients, and why is their efficacy in controlling cancerous tumors often short-lived? A research team from Roswell Park Cancer Institute has shown that at least one answer - and an excellent opportunity for unleashing the full potential of these promising immunotherapies - may lie in the body's "fight or flight" reaction to stressors and in drugs already widely used to control and temporarily disable this stress response.

31 Aug 2017

UChicago Medicine working with Novartis to offer breakthrough gene therapy for pediatric ALL patients

The University of Chicago Medicine is one of a limited number of U.S. sites working to offer a breakthrough gene therapy for pediatric acute lymphoblastic leukemia (ALL), which was just approved by the U.S. Food and Drug Administration.

31 Aug 2017

New drug shows promise to treat women with estrogen positive metastatic breast cancer

Z-endoxifen, a potent derivative of the drug tamoxifen, could itself be a new treatment for the most common form of breast cancer in women with metastatic disease.

31 Aug 2017

Olfactory tissue regeneration requires inflammatory processes that create loss of smell

In a mouse study designed to understand how chronic inflammation in sinusitis damages the sense of smell, scientists at Johns Hopkins say they were surprised to learn that the regeneration of olfactory tissue requires some of the same inflammatory processes and chemicals that create injury and loss of smell in the first place.

30 Aug 2017

New discovery reveals gut bacteria and human cells speak the same chemical language

We have a symbiotic relationship with the trillions of bacteria that live in our bodies--they help us, we help them. It turns out that they even speak the same language.

30 Aug 2017

FDA makes the first gene therapy Kymriah available for treatment of pediatric ALL

The U.S. Food and Drug Administration (FDA) has issued a press release making the first even gene therapy available for treatment of children with a form of acute lymphoblastic leukemia (ALL).

30 Aug 2017

$Novartis gets FDA approval for novel immunocellular therapy to treat relapsed or refractory B-cell ALL$

Novartis gets FDA approval for novel immunocellular therapy to treat relapsed or refractory B-cell ALL

Novartis announced today that the US Food and Drug Administration has approved Kymriah (tisagenlecleucel) suspension for intravenous infusion, formerly CTL019, the first chimeric antigen receptor T cell (CAR-T) therapy, for the treatment of patients up to 25 years of age with B-cell precursor acute lymphoblastic leukemia (ALL) that is refractory or in second or later relapse.

30 Aug 2017

Researchers synthesizing new, first-in-class drug to stop growth of ER-positive breast cancer

Researchers at UT Health San Antonio and two partner institutions are developing a new, first-in-class agent that has stopped the growth of estrogen receptor-positive (ER-positive) breast cancer in its tracks.

30 Aug 2017

New biomedical tool using nanoparticles could improve therapies for many diseases

A new biomedical tool using nanoparticles that deliver transient gene changes to targeted cells could make therapies for a variety of diseases - including cancer, diabetes and HIV - faster and cheaper to develop, and more customizable.

30 Aug 2017

Receptor News and Research

Fatty acid-derived bioactive molecule helps improve heart function after heart attack in mice

BUSM researchers show new way to reduce skin cancer risk in redheads

Researchers investigate link between thyroid hormone and red blood cell production

Heparin promotes food intake and body weight gain in animal models

High levels of suPAR protein shown to be likely cause of kidney damage in children

Novel, ultra-rare damaging genetic variants may contribute to eating disorders

Scientists show how receptors for drugs act inside cells

Better understanding of serotonin's function in the brain could lead to radical shift in psychiatric care

Long-term alcohol use changes brain functions differently in young men and women

New study offers insights on mechanisms behind development of kidney damage due to obesity

Common heart disease medication may help treat pulmonary arterial hypertension

Beta blockers capable of reducing stress signaling may enhance effectiveness of immunotherapy

UChicago Medicine working with Novartis to offer breakthrough gene therapy for pediatric ALL patients

New drug shows promise to treat women with estrogen positive metastatic breast cancer

Olfactory tissue regeneration requires inflammatory processes that create loss of smell

New discovery reveals gut bacteria and human cells speak the same chemical language

FDA makes the first gene therapy Kymriah available for treatment of pediatric ALL

Novartis gets FDA approval for novel immunocellular therapy to treat relapsed or refractory B-cell ALL

Researchers synthesizing new, first-in-class drug to stop growth of ER-positive breast cancer

New biomedical tool using nanoparticles could improve therapies for many diseases

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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