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Plant-based relatives of cholesterol could boost gene-infused nanoparticle delivery

Gene-infused nanoparticles used for combating disease work better when they include plant-based relatives of cholesterol because their shape and structure help the genes get where they need to be inside cells.

20 Feb 2020

Single gene cluster loss promotes initiation and progression of multiple myeloma in mice

The loss of one copy of the miR15a/miR16-1 gene cluster promoted initiation and progression of multiple myeloma in mice.

20 Feb 2020

New C. elegans model will accelerate study of a rare disease

The model will permit to accelerate and reduce the price of the research, which is studying the mechanisms and the possible pharmacological targets for the neuronal alterations of this disease.

20 Feb 2020

Both strands of microRNA cooperate to drive cancer growth and aggressiveness, research shows

Researchers long thought that only one strand of a double-stranded microRNA can silence genes. Though recent evidence has challenged that dogma, it's unclear what the other strand does, and how the two may be involved in cancer.

20 Feb 2020

An enriched environment helps heal young, injured brains

An enriched environment--with increased opportunities for physical activity, socialization and exploring novel stimuli--helped lessen functional, anatomical and cellular deficits in an experimental model of brain damage caused by oxygen deprivation at birth.

19 Feb 2020

Random pulsing of gene expression contributes to pattern formation during development

A team of Cambridge scientists working on the intersection between biology and computation has found that random gene activity helps patterns form during development of a model multicellular system.

19 Feb 2020

Marine herbivorous fish could be the new source of protein for humans

A secret to survival amid rising global temperatures could be dwelling in the tidepools of the U.S. West Coast.

19 Feb 2020

UCLA study finds new way for tracking treatment of rare liver disease in children

UCLA researchers who previously found that intravenous administration of fish oil can treat a rare but potentially deadly form of liver disease in children have now monitored levels of a small molecule at the center of the disorder to track treatment results.

19 Feb 2020

IU researcher identifies new genomic regions that increase skin cancer risk

An Indiana University cancer researcher has identified eight new genomic regions that increase a person's risk for skin cancer.

18 Feb 2020

Study reveals how overexposure to fluoride causes defects in tooth enamel

Exposing teeth to excessive fluoride alters calcium signaling, mitochondrial function, and gene expression in the cells forming tooth enamel- a novel explanation for how dental fluorosis, a condition caused by overexposure to fluoride during childhood, arises.

18 Feb 2020

Persistent antisocial behavior linked to smaller brain size

Antisocial behavior is characterized by disruptive acts of intentional aggression that causes distress, alarm, or harassment toward others. People who exhibit antisocial behavior since they were children through adulthood are more likely to have smaller brains, a new study found.

18 Feb 2020

Researchers uncover genetic mechanisms that govern brain plasticity

Genetic mechanisms that govern brain plasticity - the brain's ability to change and adapt - have been uncovered by researchers at the University of Birmingham.

18 Feb 2020

Genetic tests to predict heart disease risk have limited benefit

Genetic tests to predict a person's risk of heart disease and heart attack have limited benefit over conventional testing.

18 Feb 2020

Statins could reduce ovarian cancer risk, study suggests

A genetic study has found evidence to suggest that women who take statins in the long term could be less likely to develop ovarian cancer, according to new research funded by Cancer Research UK published today (Tuesday 18 February).

18 Feb 2020

Study provides insight into link between cancer driver gene and alternative splicing changes

A multi-institutional group of researchers led by Children's Hospital of Philadelphia has linked a strong cancer driver gene to changes in proteins that regulate alternative splicing.

17 Feb 2020

Increased risk of uterine cancer linked to 24 gene variants

The risk of uterine endometrial cancer is increased by 24 gene variants that code for different cellular processes such as cell growth and death, gene regulation, and estrogen metabolism, according to a comprehensive review published in the Journal of Medical Genetics.

17 Feb 2020

UT Southwestern scientists discover potential vulnerabilities in new coronavirus

UT Southwestern Medical Center data scientists analyzing genetic sequences of the COVID-19 coronavirus have identified potential vulnerabilities that could help in vaccine development and further study of the infectious disease now spreading worldwide.

17 Feb 2020

Neuroscientist breaks the communication code of mice

You can't call it a dictionary just yet, but University of Delaware neuroscientist Joshua Neunuebel is starting to break the code mice use to communicate with each other.

17 Feb 2020

Targeting regulatory T cells could boost the effects of cancer immunotherapy

A Ludwig Cancer Research study has identified a mechanism by which regulatory T cells, which suppress immune responses, adapt their metabolism to thrive in the harsh microenvironment of the tumor.

17 Feb 2020

Fragile X syndrome-causing repeats help human neurons function, study finds

Over half of our genomes are made of repeating elements within DNA. In rare cases, these repeats can become unstable and grow in size. These repeat "expansions" cause neurodegenerative diseases such as ALS and dementia as well as learning disorders and autism in Fragile X syndrome.

17 Feb 2020