Protein C News and Research

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Conformational variation of the SARS-CoV-2 energy landscape

Researchers demonstrate that the energy landscape of SARS-CoV-2 exhibits significant conformational variation.

14 Mar 2022

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Researchers demonstrate enhanced loss-of-function editing of CRISPR/Cas9 in human cells.

14 Mar 2022

Role of carboxypeptidase U in severe COVID-19

A new study measured both proCPU and CPU+CPUi over time to determine the impact of SARS-CoV-2 infection on the CPU system.

14 Mar 2022

Sino Biological Invests Over 200M RMB to Establish New Subsidiaries in Taizhou and Suzhou, China.

Sino Biological is pleased to announce the formation of two new operationally-focused subsidiaries in China.

From Sino Biological Inc. 14 Mar 2022

In silico screening of natural ACE2 inhibitors

Researchers identify potential ACE2 inhibitors through a virtual screening protocol.

14 Mar 2022

Neutralizing activity of therapeutic antibodies against clinical strains of BA.1 and BA.2 sub-lineages of the Omicron variant

Researchers conducted an in vitro analysis to assess the efficacy of monoclonal antibodies against the SARS-CoV-2 Omicron BA.2 and BA.1 variants.

14 Mar 2022

The impact of PLEX on the survival of patients with severe COVID-19 and the effect on the cytokine release syndrome

Researchers evaluated the survival benefit conferred by PLEX in patients with severe COVID-19 and cytokine-storm syndrome.

14 Mar 2022

Insight into oligodendrocytes in the brain could shed light on the causes of neurodegenerative diseases

New research may help scientists locate immature cells in the central nervous system that could shed light on the causes of neurodegenerative diseases like multiple sclerosis - and autoimmune disease that affects the brain and nervous system - and allow for the development of better therapeutic treatments.

12 Mar 2022

Researchers develop a system of synthetic biosensors to assess the response of cancer therapy

Immune checkpoint blockade (ICB) inhibitors have transformed the treatment of cancer and have become the frontline therapy for a broad range of malignancies. It's because they work better than the previous standard of care.

11 Mar 2022

Study may provide insight into the evolution of D-amino acid function in marine invertebrates

Amino acids are the basic building blocks of living organisms and typically occur in a configuration known as the L-form. However, there are a few exceptional examples of the structural mirror image of the L-form (known as the D-form) being present in animals.

11 Mar 2022

Imaging reveals molecular process used by corals to control algal symbionts' subcellular environment

Researchers at UC San Diego's Scripps Institution of Oceanography have discovered a novel molecular process that corals use to control the subcellular environment of the algae that live inside them.

11 Mar 2022

Antibody treatment improves symptoms of neuromyelitis optica in a rat model

Autoimmune diseases are the molecular equivalent of "friendly fire": the body attacks itself instead of harmful invaders.

11 Mar 2022

Study shows the mutations leading to omicron variant did not help virus escape recognition by T cells

People who gained immunity - either through vaccination or exposure - against the original strain of SARS-CoV-2, the virus that causes COVID-19, also are likely to have some protection against the pathogen's omicron variant.

11 Mar 2022

Exploring SARS-CoV-2 spike evolution in relation to sensitivity to antiviral restriction factors

Researchers investigated the effects of SARS-CoV-2 spike mutations on antiviral restriction mediated by interferon-induced transmembrane proteins and guanylate binding proteins.

11 Mar 2022

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Researchers screened 5,000 Food and Drug Association-approved drugs to identify repurposed drugs targeting SARS-CoV-2 spike protein cleavage at both S1/S2 boundary and S2’.

11 Mar 2022

Updated results from ongoing study on the effect of a BNT162b2 booster dose on anti-SARS-CoV-2 antibodies

Researchers assessed the increase in Pfizer/BioNTech BNT162b2 vaccine efficacy on administering a homologous booster dose.

11 Mar 2022

Study suggests increased durability of immune responses towards SARS-CoV-2 spike protein after BNT62b2 booster

Researchers evaluated the immune responses after boosting with Pfizer's BNT162b2 vaccine.

11 Mar 2022

Study shows SARS-CoV-2 infection induces global alterations of the host endomembrane system

Researchers observed that Golgi fragmentation induced by SARS-CoV-2 facilitates viral trafficking.

11 Mar 2022

Aminoglycoside antibiotic geneticin shows selective antiviral effect against SARS-CoV-2

Researchers elucidated antiviral activities of aminoglycoside geneticin against seven SARS-CoV-2 variants using different cell lines and respiratory tissues.

11 Mar 2022

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Researchers discovered and optimized cysteine-reactive pyrazoline-based covalent inhibitors for several coronaviruses' Mpro, including SARS-CoV-2.

11 Mar 2022

Protein C News and Research

Conformational variation of the SARS-CoV-2 energy landscape

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Role of carboxypeptidase U in severe COVID-19

Sino Biological Invests Over 200M RMB to Establish New Subsidiaries in Taizhou and Suzhou, China.

In silico screening of natural ACE2 inhibitors

Neutralizing activity of therapeutic antibodies against clinical strains of BA.1 and BA.2 sub-lineages of the Omicron variant

The impact of PLEX on the survival of patients with severe COVID-19 and the effect on the cytokine release syndrome

Insight into oligodendrocytes in the brain could shed light on the causes of neurodegenerative diseases

Researchers develop a system of synthetic biosensors to assess the response of cancer therapy

Study may provide insight into the evolution of D-amino acid function in marine invertebrates

Imaging reveals molecular process used by corals to control algal symbionts' subcellular environment

Antibody treatment improves symptoms of neuromyelitis optica in a rat model

Study shows the mutations leading to omicron variant did not help virus escape recognition by T cells

Exploring SARS-CoV-2 spike evolution in relation to sensitivity to antiviral restriction factors

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Updated results from ongoing study on the effect of a BNT162b2 booster dose on anti-SARS-CoV-2 antibodies

Study suggests increased durability of immune responses towards SARS-CoV-2 spike protein after BNT62b2 booster

Study shows SARS-CoV-2 infection induces global alterations of the host endomembrane system

Aminoglycoside antibiotic geneticin shows selective antiviral effect against SARS-CoV-2

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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