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Researchers elucidate mechanism that induces skeletal muscle atrophy in patients with congestive heart failure

It is a paradox: Patients with advanced congestive heart failure lose skeletal muscle mass, but their heart muscles become enlarged to provide the body with an adequate supply of blood and thus with oxygen. It has long been known that the protein angiotensin II plays a villainous role in this process, but the exact mechanism has remained unclear.

12 Aug 2015

Sigma 1 receptor appears to play vital role in supporting the retina

A receptor that is already a target for treating neurodegenerative disease also appears to play a key role in supporting the retina, scientists report.

11 Aug 2015

Researchers identify genome-organizing mechanism that transmits vital genetic materials during mitosis

Chromosomes are responsible for carrying our genes and essentially protecting the information that helps ensure normal, healthy growth, with vital instructions being passed on from cell to cell by a process known as mitosis. While this copying mechanism has been well understood for decades, scientists have been unable to describe exactly how genetic information is protected and properly segregated as mitosis is happening.

7 Aug 2015

FAU researchers identify endogenous process that controls reproduction of cardiac muscle cells

Heart failure is the most common cause of death worldwide. The main reason for this is that damage to the human heart causes cardiac muscle cells to die, which in turn leads to reduced heart function and death. However, this is not the case for zebrafish or amphibians. If their hearts become damaged and cardiac muscle cells die, their remaining cardiac muscle cells can reproduce, allowing the heart to regenerate.

7 Aug 2015

Researchers develop new technology to track DNA-protein binding in live cells

Researchers have developed a new technology that precisely marks where groups of regulatory proteins called transcription factors bind DNA in the nuclei of live cells.

7 Aug 2015

McGill researchers identify brain structures involved in delayed gratification

Researchers at McGill have clearly identified, for the first time, the specific parts of the brain involved in decisions that call for delayed gratification. In a paper recently published in the European Journal of Neuroscience, they demonstrated that the hippocampus (associated with memory) and the nucleus accumbens (associated with pleasure) work together in making critical decisions of this type, where time plays a role.

5 Aug 2015

DBS may aid cortical plasticity in Parkinson’s patients

Deep-brain stimulation of the subthalamic nucleus may help to restore long-term potentiation-like plasticity in the motor cortex of patients with Parkinson’s disease, a study shows.

4 Aug 2015

Research: Critical aspects of human genome's regulatory program encoded by genomic sequence elements

Since the classical studies of Jacob and Monod in the early 1960s, it has been evident that genome sequences contain not only blueprints for genes and the proteins that they encode, but also the instructions for a coordinated regulatory program that governs when, where and to what extent these genes and proteins are expressed.

4 Aug 2015

Researchers uncover new mechanism that p53 protein uses to trigger cell death

Researchers have identified a new mechanism that the tumor suppressor protein p53 uses to trigger cell death via apoptosis and have shown how the process could be harnessed to kill cancer cells. St. Jude Children's Research Hospital scientists led the study, which appears today in the scientific journal Molecular Cell.

31 Jul 2015

Balancing cellular aging and cancer risk through biotechnology

In a way, trying to repair age-related heart damage and trying to fight cancer are opposite problems. Your heart cells' ability to regenerate themselves and proliferate into new, young cells degrades as you get older.

30 Jul 2015

U of T researchers discover DNA ambulance

U of T researchers have discovered how severely damaged DNA is transported within a cell and how it is repaired.

24 Jul 2015

Study reveals potential new therapeutic target for depression treatment

Increasing the levels of a signaling molecule found in the brain can positively alter response to stress, revealing a potential new therapeutic target for treatment of depression, UT Southwestern Medical Center researchers said.

22 Jul 2015

Emory University immunologists identify long-lived antibody-producing cells in bone marrow

Immunologists from Emory University have identified a distinct set of long-lived antibody-producing cells in the human bone marrow that function as an immune archive.

16 Jul 2015

Research breakthrough opens door to a world of regenerative medicine for treating mitochondrial disease

A study led by Shoukhrat Mitalipov, Ph.D., and Hong Ma, M.D., Ph.D., at the Center for Embryonic Cell and Gene Therapy at Oregon Health & Science University and the Oregon National Primate Research Center has revealed the first critical step in developing novel gene and stem cell therapy treatments for patients with mitochondrial disease.

16 Jul 2015

Research could lead to new approaches to treating spinal cord and brain injuries

Many an injury will heal, but the damaged spinal cord is notoriously recalcitrant. There's new hope on the horizon, though. A team of researchers led by the University of South Carolina's Jeff Twiss just reported an innate repair mechanism in central nervous system axons that might be harnessed to regenerate nerves after brain or spinal cord injuries.

16 Jul 2015

U of T researchers discover new details about key gene involved in ALS

A University of Toronto research team has discovered new details about a key gene involved in ALS, perhaps humanity's most puzzling, intractable disease.

16 Jul 2015

Salk researchers move one step closer to making cures for genetic diseases a reality

Healthy brain, muscle, eye and heart cells would improve the lives of tens of thousands of people around the world with debilitating mitochondrial diseases. Now, researchers at the Salk Institute have gotten one step closer to making such cures a reality: they've turned cells from patients into healthy, mutation-free stem cells that can then become any cell type.

16 Jul 2015

New understanding of keratin 17 protein could lead to development of better ways to prevent cancer

New research from the Johns Hopkins Bloomberg School of Public Health suggests that the protein keratin 17 - the presence of which is used in the lab to detect and stage various types of cancers - is not just a biomarker for the disease, but may play a critical role in tumor growth.

14 Jul 2015

Researchers reveal how certain lipids help adenoviruses to enter the cell

Adenoviruses cause numerous diseases, such as eye or respiratory infections, and they are widely used in gene therapy. Researchers from the University of Zurich have now discovered how these viruses penetrate the cells, a key step for infection and gene delivery. The cell unwillingly supports virus entry and infection by providing lipids that are normally used to repair damaged membranes.

10 Jul 2015

Defects in mitochondria play key role in transition of normal cells to cancerous cells

Cancer cells defy the rules by which normal cells abide. They can divide without cease, invade distant tissues and consume glucose at abnormal rates.

9 Jul 2015

Cell Nucleus News and Research

Researchers elucidate mechanism that induces skeletal muscle atrophy in patients with congestive heart failure

Sigma 1 receptor appears to play vital role in supporting the retina

Researchers identify genome-organizing mechanism that transmits vital genetic materials during mitosis

FAU researchers identify endogenous process that controls reproduction of cardiac muscle cells

Researchers develop new technology to track DNA-protein binding in live cells

McGill researchers identify brain structures involved in delayed gratification

DBS may aid cortical plasticity in Parkinson’s patients

Research: Critical aspects of human genome's regulatory program encoded by genomic sequence elements

Researchers uncover new mechanism that p53 protein uses to trigger cell death

Balancing cellular aging and cancer risk through biotechnology

U of T researchers discover DNA ambulance

Study reveals potential new therapeutic target for depression treatment

Emory University immunologists identify long-lived antibody-producing cells in bone marrow

Research breakthrough opens door to a world of regenerative medicine for treating mitochondrial disease

Research could lead to new approaches to treating spinal cord and brain injuries

U of T researchers discover new details about key gene involved in ALS

Salk researchers move one step closer to making cures for genetic diseases a reality

New understanding of keratin 17 protein could lead to development of better ways to prevent cancer

Researchers reveal how certain lipids help adenoviruses to enter the cell

Defects in mitochondria play key role in transition of normal cells to cancerous cells

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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