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Scientists identify immunogens that can elicit antibody responses against multiple SARS-CoV-2 variants

In a new study, researchers identified conserved sites in the SARS-CoV-2 spike protein using structural and sequence data, and then combined the results with existing deep mutational scanning data to design six antigens that can offer protection against significant immune escape mutations in the SARS-CoV-2 receptor-binding domain.

27 Jan 2022

Recipients of inactivated COVID-19 vaccine (CoronaVac) can be successfully boosted with different vaccines

In the recently published study in The Lancet, first-authored by Dr. Sue Ann Costa Clemens from the University of Oxford in the United Kingdom and the University of Siena in Italy, a comprehensive analysis has been pursued on the immunogenicity and safety of both homologous and heterologous boosting after receiving the inactivated vaccine CoronaVac.

26 Jan 2022

Immunosuppressed patients can benefit from COVID-19 booster vaccination, study shows

Patients under immunosuppressive therapy, who do not respond to primary COVID-19 vaccination, have an increased risk for severe COVID-19 disease courses. Until now, it was not clear whether those patients at risk can benefit from an additional booster vaccination.

26 Jan 2022

Study suggests synthetic SARS-CoV-2 S glycoprotein coated lipid vesicles are an effective vaccine candidate

In a new study, a team of researchers developed a vaccine candidate with the SARS-CoV-2 spike (S) glycoprotein coated onto lipid vesicles which resembles virus-like particles.

26 Jan 2022

SARS-CoV-2 Omicron variant found to display increased resilience to antiviral type I interferon response

In a new study, scientists have compared the Omicron variant with the Delta VOC (B.1.617.2) as well as the wildtype strain (B.1), with respect to their interaction with the antiviral type 1 interferon response in infected cells.

26 Jan 2022

COVID-19 vaccine does not lead to infertility in either men or women

In a recent prospective cohort study accepted to the American Journal of Epidemiology, researchers observed links between female and male coronavirus disease 2019 (COVID-19) vaccination and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and fecundability or the per-cycle likelihood of conception in North American couples seeking to conceive.

26 Jan 2022

Development of synthetic molecules that can bridge T cells with SARS-CoV-2 infected cells

Scientists have recently used synthetic biology to design primary human CD8 T cells to express Spike protein-specific chimeric antigen receptors (ACE2 CAR or anti-Spike CAR).

25 Jan 2022

Broad and potent neutralizing activity of human IgG1 LALA antibody against SARS-CoV-2 variants

A new study has focused on the identification, in vitro binding, and potent neutralizing activity of STI-9167 (plutavimab) against live viruses and pseudotype viruses.

25 Jan 2022

Vaccine wars ignite in California as lawmakers seek stronger laws

California is poised to become the front line of America's vaccination wars. State lawmakers are drafting the toughest covid-19 vaccine legislation in the country, backed by a new pro-vaccine lobbying force promising to counter anti-vaccine activists who have threatened government officials and shut down public meetings across the state.

24 Jan 2022

CoronaVac provides herd immunity in region of the Colombian Amazon

Researchers determine the effectiveness of the CoronaVac® vaccine in a Colombian Amazon population.

23 Jan 2022

Study supports that Omicron variant has shifted to better usage of Cathepsin B/L entry pathway

A new study analyzed new data on the Omicron variant and indicated the altered cell entry pathways compared to other variants.

21 Jan 2022

New report reveals the alarming global impact of Group B streptococcus

A new report from the World Health Organization (WHO) and the London School of Hygiene & Tropical Medicine (LSHTM) reveals the alarming global impact of Group B streptococcus (GBS) – a common bacterium that can be transmitted in the womb, during birth, or in the early weeks of life – leading to around 150,000 deaths of babies each year, more than half a million preterm births and significant long-term disability.

20 Jan 2022

Antibodies to SARS-CoV-2 and infection risk in healthcare workers following mRNA vaccination

A new study aimed to understand the risk of COVID-19 infection given certain serological parameters, in a group of vaccinated healthcare workers with high rates of exposure to the virus, followed up at 9 months from vaccination.

20 Jan 2022

Study reports of receptor-binding domain multimer capable of enhancing the immune response against SARS-CoV-2

Researchers have discovered a new way to induce immunity against the RBD.

19 Jan 2022

School closures for in-person learning during the pandemic have lasting effects on children

The impact virtual school had on kids goes well beyond academics, say Children's National Hospital experts in a new JAMA Pediatrics editorial.

18 Jan 2022

Study predicts incidence rates of adverse outcomes of COVID-19 vaccination

In a new study, a team of researchers estimated the pre-pandemic incidence rates of adverse events of special interest now observed in association with COVID-19 vaccines in Canada.

18 Jan 2022

Study evaluates acute and long-term adverse events following immunization with COVID-19 Moderna vaccine

In a new study, a team of researchers conducted a case-control study at a mass vaccination center in Japan to evaluate acute and long-term adverse events following immunization (AEFI) with coronavirus disease 2019 (COVID-19) Moderna vaccine.

17 Jan 2022

Study investigates whether immune responses to BNT162b2 vaccine differ in subjects with and without prior SARS-CoV-2 infection

A new paper published in the journal JCI Insight reports on the differential levels of immunity achieved in those with and without a history of prior infection with the virus following one and two doses of the earliest vaccines to be approved for emergency use.

17 Jan 2022

SARS-CoV-2 Omicron has similar infectious viral load to Delta

Researchers compare SARS-CoV-2 pre-variants of concern strains to the Delta and Omicron VOCs.

16 Jan 2022

As omicron surges, effort to vaccinate young children stalls

Two months after Pfizer's covid vaccine was authorized for children ages 5 to 11, just 27% have received at least one shot, according to Jan. 12 data from the Centers for Disease Control and Prevention. Only 18%, or 5 million kids, have both doses.

15 Jan 2022

Immunization News and Research

Scientists identify immunogens that can elicit antibody responses against multiple SARS-CoV-2 variants

Recipients of inactivated COVID-19 vaccine (CoronaVac) can be successfully boosted with different vaccines

Immunosuppressed patients can benefit from COVID-19 booster vaccination, study shows

Study suggests synthetic SARS-CoV-2 S glycoprotein coated lipid vesicles are an effective vaccine candidate

SARS-CoV-2 Omicron variant found to display increased resilience to antiviral type I interferon response

COVID-19 vaccine does not lead to infertility in either men or women

Development of synthetic molecules that can bridge T cells with SARS-CoV-2 infected cells

Broad and potent neutralizing activity of human IgG1 LALA antibody against SARS-CoV-2 variants

Vaccine wars ignite in California as lawmakers seek stronger laws

CoronaVac provides herd immunity in region of the Colombian Amazon

Study supports that Omicron variant has shifted to better usage of Cathepsin B/L entry pathway

New report reveals the alarming global impact of Group B streptococcus

Antibodies to SARS-CoV-2 and infection risk in healthcare workers following mRNA vaccination

Study reports of receptor-binding domain multimer capable of enhancing the immune response against SARS-CoV-2

School closures for in-person learning during the pandemic have lasting effects on children

Study predicts incidence rates of adverse outcomes of COVID-19 vaccination

Study evaluates acute and long-term adverse events following immunization with COVID-19 Moderna vaccine

Study investigates whether immune responses to BNT162b2 vaccine differ in subjects with and without prior SARS-CoV-2 infection

SARS-CoV-2 Omicron has similar infectious viral load to Delta

As omicron surges, effort to vaccinate young children stalls

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