Protein C News and Research

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Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

A new study used glycoprotein profiling technology platform that couples high-resolution LC-MS for glycoprotein analysis in regards to COVID-19.

9 Mar 2022

Single protein elicits multilineage reprogramming of astrocytes in adult mouse brains

A single protein can reverse the developmental clock on adult brain cells called astrocytes, morphing them into stem-like cells that produce neurons and other cell types, UT Southwestern researchers report in a PNAS study.

9 Mar 2022

The relationship between highly conserved residues in the SARS CoV fusion peptide and their role in coordinating calcium binding for viral entry

Researchers evidenced the significance of calcium in mediating the interaction between the coronaviruses fusion peptide and host cell membrane to provide insights into the mechanisms of viral entry.

9 Mar 2022

CRIPSR identifies cell-type-specific ACE2 modifiers

Researchers compile a list of candidate genes to identify the surface abundance of functional regulators of ACE2.

9 Mar 2022

Intragenomic rearrangements help explain how SARS-CoV-2 variants arise

In a recent study posted to the bioRxiv* preprint server, researchers presented the intragenomic rearrangements of β-coronaviruses (CoVs), including severe acute respiratory syndrome CoV 2 (SARS-CoV-2).

9 Mar 2022

Elevated P2X7 receptor levels in COVID-19 patients correlate with disease severity

In a recent study posted to the bioRxiv preprint server, researchers demonstrated that the soluble P2X7 receptor is increased in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients. They also showed that the elevated P2X7 receptors correlated with coronavirus disease 2019 (COVID-19) severity.

9 Mar 2022

Lower exosome component 2 expression protects against clinical SARS-CoV-2 infection

In a recent study posted to the bioRxiv* preprint server, researchers demonstrated that the lower expression of EXOSC2 human protein safeguards from clinical coronavirus disease 2019 (COVID-19). This protective effect was via the reduced EXOSC2 expression-associated suppression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication.

9 Mar 2022

Assessment of oligonucleotides as COVID-19 treatment

A recent study posted to the bioRxiv* pre-print server assessed the ability of oligonucleotides in preventing the development of infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions.

8 Mar 2022

Whole-genome sequencing for determination of factors associated with critical COVID-19

In a recent study published in the journal Nature as an early release unedited manuscript, researchers conducted whole genomic sequencing (WGS) to ascertain factors contributing to critical coronavirus disease 2019 (COVID-19).

8 Mar 2022

Study suggests recent common cold may actually lead to worse COVID-19 disease

A new study published in the Journal of Infectious Diseases shines an unexpected light on the notion that pre-existing immunity to common cold coronaviruses can protect us from coronavirus disease 2019 (COVID-19) – and reveals that this may actually put certain individuals at risk of more severe clinical presentations.

8 Mar 2022

Researchers secure $12 million grant to develop improved therapies for hemophilia

An Indiana University School of Medicine researcher will lead a multi-institute effort toward improved therapies for hemophilia with help from a $12 million grant from the National Heart Lung and Blood Institute.

8 Mar 2022

Unusual partners are key to making more blood vessels

Insufficient oxygen to an area like the heart or legs, called hypoxia, is a cue to our bodies to make more blood vessels, and scientists have found some unusual partners are key to making that happen.

8 Mar 2022

Research sheds light on important events that may play a role in infertility

Everyone considers sperm to be made exclusively by males. But did you know that females also make sperm? Well, it turns out that females also contribute to what makes a sperm a sperm.

8 Mar 2022

Three new drug companies join the COVIDRIVE consortium to study vaccine effectiveness

Three new drug companies (Moderna, Novavax and Valneva) have joined the COVIDRIVE consortium, becoming partners of this project coordinated by the Vaccine Research Department of the Foundation for the Promotion of Health and Biomedical Research of Valencia Region (Fisabio), an affiliate of the Conselleria de Sanitat Universal i Salut Pública, along with the company specialized in pharmacovigilance and epidemiology, P95.

8 Mar 2022

A new view of SARS-CoV-2 genome structure

Researchers performed DMS mutational profiling with sequencing and DREEM clustering to determine the SARS-CoV-2 RNA secondary structure.

8 Mar 2022

How will mutations change the SARS-CoV-2 spike protein in the future?

A new Cells review discusses the factors that affect the function of the SARS-CoV-2 S protein and provides theoretical limits of this viral protein.

8 Mar 2022

Biotech spinout receives $42 million to develop 'future-proofed' coronavirus vaccines

Prime Minister Boris Johnson today announced that DIOSynVax, a biotech spinout of the University of Cambridge, will receive $42million to develop a vaccine candidate that could provide protection against both existing and future variants of SARS-CoV-2 - the virus that causes COVID-19 - as well as other major coronaviruses, including those that cause SARS and MERS.

8 Mar 2022

Protein C News and Research

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

Single protein elicits multilineage reprogramming of astrocytes in adult mouse brains

The relationship between highly conserved residues in the SARS CoV fusion peptide and their role in coordinating calcium binding for viral entry

CRIPSR identifies cell-type-specific ACE2 modifiers

Intragenomic rearrangements help explain how SARS-CoV-2 variants arise

Elevated P2X7 receptor levels in COVID-19 patients correlate with disease severity

Lower exosome component 2 expression protects against clinical SARS-CoV-2 infection

Assessment of oligonucleotides as COVID-19 treatment

Whole-genome sequencing for determination of factors associated with critical COVID-19

Study suggests recent common cold may actually lead to worse COVID-19 disease

Researchers secure $12 million grant to develop improved therapies for hemophilia

Unusual partners are key to making more blood vessels

Research sheds light on important events that may play a role in infertility

Three new drug companies join the COVIDRIVE consortium to study vaccine effectiveness

A new view of SARS-CoV-2 genome structure

How will mutations change the SARS-CoV-2 spike protein in the future?

Biotech spinout receives $42 million to develop 'future-proofed' coronavirus vaccines

Scientists shed light on placenta's role in transferring vitamin D to fetus during pregnancy

New analysis method to identify interacting proteins in a protein degrader-dependent manner

UH researchers receive grant for developing new imaging technique to peer into ribosomes

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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