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Study reveals potential therapeutic target to tackle ADHD and impulsivity

A study published in the journal Pharmacological Research describes the existence of a complex built by dopamine and noradrenergic receptors that could be a therapeutic target of potential interest to tackle the attention deficit hyperactivity disorder (ADHD) and impulsivity.

23 Sep 2021

Design of mRNA vaccines to combat COVID-19

A recent review study discusses fundamental concepts in the successful delivery of nucleic acids in therapeutics.

23 Sep 2021

Study finds spousal similarities in the incidences of some diseases

A couple's health is surprisingly intertwined according to a recent cohort study that looked at Dutch and Japanese marriages.

23 Sep 2021

Scientists characterize new genetic variants that cause nonsyndromic neurodevelopmental disorder

Northwestern Medicine scientists have characterized several variants of the gene GRIK2 that cause nonsyndromic neurodevelopmental disorder (NDD), according to a study published in the American Journal of Human Genetics.

23 Sep 2021

People with natural immunity and subsequent mRNA vaccination can neutralize viral particles capable of resisting vaccine-induced antibodies

New research suggests SARS-CoV-2 spike protein substitution mutations can create a replication-defective viral particle that makes the virus resistant to vaccine-induced antibodies.

23 Sep 2021

Differences in blood gene expression among patients with varying COVID-19 severity

A new study published on the medRxiv* pre-print server and currently undergoing peer-review aims to answer this question through whole blood transcriptomics of individuals with varying degrees of COVID-19 severity. Transcriptomics, done by RNA sequencing, gives insights into the genes expressed in a cell at a given time point. It gives an analysis of all RNA molecules within a cell, in this case, whole blood.

23 Sep 2021

Genome modeling framework for coronavirus pathogenicity prediction

Recent machine learning techniques have allowed viral genome sequencing to be utilized in a predictive capacity.

23 Sep 2021

DNA sensor can detect infectious viruses in minutes

A new sensor can detect not only whether a virus is present, but whether it's infectious – an important distinction for containing viral spread.

23 Sep 2021

Study provides novel insights into how KLF4 influences gene expression

A team led by researchers at Baylor College of Medicine has discovered a mechanism by which transcription factor KLF4 can help to organize chromatin, thus influencing gene expression.

23 Sep 2021

Sex, age are crucial factors in the care and survival of patients with malignant brain tumors

Findings from a national study by researchers at Translational Genomics Research Institute (TGen), an affiliate of City of Hope, and external collaborators suggest that sex and age are crucial factors in the care and survival of patients with malignant brain tumors and other central nervous systems (CNS) cancers.

23 Sep 2021

MMRI explores overlapping cardiac conditions as result of electrocution

It's not uncommon for people to live normal, healthy lives without knowledge of any underlying genetic conditions. However, all it takes is one external impact, such as a heart attack, to induce the expression of the condition.

22 Sep 2021

New treatment approaches offer hope to minimize hair thinning in middle-aged women

Hair loss in middle-aged females is common, affecting up to two-thirds of women after menopause. The exact reasons remain unclear, although evidence suggests a hormonal and genetic predisposition.

22 Sep 2021

Hypertonic saline solution shown to inhibit replication of SARS-CoV-2

Researchers at the University of São Paulo (USP) in Brazil have shown that a hypertonic saline solution inhibits replication of SARS-CoV-2, the virus that causes COVID-19, and have elucidated the biochemical mechanism involved.

22 Sep 2021

SARS-CoV-2 genome signature leads to replicative advantage in presence of Remdesivir

A new study indicates that low-level resistance of SARS-CoV-2 to remdesivir is not widespread and dissimilar to other RNA viruses revealing evolutionary predictability of this pandemic virus.

22 Sep 2021

New framework needed to explore links between evolved pathogen tolerance and emerging infections

A new multidisciplinary research framework is needed to explore links between evolved tolerance to pathogens and their spillover into humans, scientists write today in the journal eLife.

22 Sep 2021

Repeated injury to the epithelial tissue of airways causes "biological aging" of stem cells

Are prematurely aged or overworked stem cells a significant factor in chronic lung disease? Findings of a study just released in STEM CELLS Translational Medicine (SCTM) say this is likely so.

22 Sep 2021

Researchers identify distinctive biological markers for earlier detection of pregnancy risks

Researchers from Flinders University and the Robinson Research Institute at the University of Adelaide have identified distinctive biological markers that could improve the routine blood tests pregnant women already undergo and detect risks for pregnancy complications earlier than currently possible.

22 Sep 2021

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas

Mutations in the ARID1A gene are present in more than 50% of ovarian clear cell carcinomas (OCCC), for which effective treatments are lacking. Scientists at The Wistar Institute discovered that loss of ARID1A function enhances a cellular stress response pathway that promotes survival of cancer cells, which become sensitive to pharmacological inhibition of this pathway. These findings were published online in Cancer Research, a journal of the American Association for Cancer Research, and point to a new therapeutic opportunity for this type of ovarian cancer for which new solutions are urgently needed.

22 Sep 2021

Scientists use statistical mechanics to make sense of DNA folding

At more than 2 meters long, the human DNA molecule uses intricate folding patterns to fit into cells while locally unfolding to express genes. Such phenomena, however, are difficult to measure in experiments, and theoretical frameworks explaining them continue to be at odds with one another.

22 Sep 2021

Revival of the cell and gene therapy field opens new avenues for repairing the Parkinsonian brain

After several decades of pre-clinical development, cell- and gene-based therapies for Parkinson's disease (PD) are now actively being explored.

21 Sep 2021

Genetic News and Research

Study reveals potential therapeutic target to tackle ADHD and impulsivity

Design of mRNA vaccines to combat COVID-19

Study finds spousal similarities in the incidences of some diseases

Scientists characterize new genetic variants that cause nonsyndromic neurodevelopmental disorder

People with natural immunity and subsequent mRNA vaccination can neutralize viral particles capable of resisting vaccine-induced antibodies

Differences in blood gene expression among patients with varying COVID-19 severity

Genome modeling framework for coronavirus pathogenicity prediction

DNA sensor can detect infectious viruses in minutes

Study provides novel insights into how KLF4 influences gene expression

Sex, age are crucial factors in the care and survival of patients with malignant brain tumors

MMRI explores overlapping cardiac conditions as result of electrocution

New treatment approaches offer hope to minimize hair thinning in middle-aged women

Hypertonic saline solution shown to inhibit replication of SARS-CoV-2

SARS-CoV-2 genome signature leads to replicative advantage in presence of Remdesivir

New framework needed to explore links between evolved pathogen tolerance and emerging infections

Repeated injury to the epithelial tissue of airways causes "biological aging" of stem cells

Researchers identify distinctive biological markers for earlier detection of pregnancy risks

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas

Scientists use statistical mechanics to make sense of DNA folding

Revival of the cell and gene therapy field opens new avenues for repairing the Parkinsonian brain

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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