Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

'Rippled beta sheet' protein structure created and characterized using x-ray crystallography

An unusual protein structure known as a "rippled beta sheet," first predicted in 1953, has now been created in the laboratory and characterized in detail using x-ray crystallography.

2 Sep 2022

How does ACE2 expression in target cells affect neutralization by antibodies to different spike epitopes?

Researchers evaluated how ACE2 expression in target cells impacts neutralization.

2 Sep 2022

What is currently known about immune responses to COVID-19 vaccines and cellular immune responses against SARS-CoV-2?

Researchers summarized existing data on the immunogenicity of COVID-19 vaccines and the humoral and cellular immune responses against SARS-CoV-2.

2 Sep 2022

The origins, breadth, and resolution of autoreactivity in severe COVID-19

Researchers assessed naïve B cells and autoreactivity in severe COVID-19.

2 Sep 2022

The effects of SARS-CoV-2 infection on antibody and B-cell responses to a third dose of mRNA vaccination

Researchers assessed the impact of COVID-19 infection on B-cell and antibody responses to COVID-19 booster vaccination.

2 Sep 2022

The dynamics of neutralizing antibodies in a cohort of children and adolescents after SARS-CoV-2 infection

In a recent JAMA Pediatrics study, scientists analyzed a cohort containing children and adolescents after recovering from COVID-19 to determine the dynamics of neutralizing antibodies.

2 Sep 2022

A rapid and efficient method of identifying neutralizing nanobodies directed against SARS-CoV-2

A recent PLoS ONE study detected neutralizing nanobodies against SARS-CoV-2 from nanobody phage display libraries and via in vitro and ex vivo high-throughput screenings.

2 Sep 2022

Depletion of reactive astrocytes regresses glioblastoma

A groundbreaking study at Tel Aviv University effectively eradicated glioblastoma, a highly lethal type of brain cancer. The researchers achieved the outcome using a method they developed based on their discovery of two critical mechanisms in the brain that support tumor growth and survival: one protects cancer cells from the immune system, while the other supplies the energy required for rapid tumor growth. The work found that both mechanisms are controlled by brain cells called astrocytes, and in their absence, the tumor cells die and are eliminated.

2 Sep 2022

Researchers develop novel therapeutic strategy to treat Huntington's disease

Through an international joint research effort involving ProQR Therapeutics of the Netherlands, Université Grenoble Alpes of France, and KTH Royal Institute of Technology of Sweden, Professor Ji-Soon Song's research team in the Department of Biological Sciences and KAIST Institute for BioCentury of KAIST, established a noble strategy to treat Huntington's disease. The new works showed that the protein converted from disease form to its disease-free form maintains its original function, providing new roadblocks to approach Huntington's disease.

2 Sep 2022

CDC recommends Novavax's COVID-19 vaccine to be used as primary series option for adolescents

Today, CDC Director Rochelle P. Walensky, M.D., M.P.H., signed a decision memo that Novavax's COVID-19 vaccine be used as another primary series option for adolescents ages 12 through 17.

1 Sep 2022

Study provides a comprehensive view of the genomics of all childhood ALL subtypes

Scientists have created a roadmap of the genetic mutations present in the most common childhood cancer, acute lymphoblastic leukemia (ALL).

1 Sep 2022

New substance boosts the effect of protein-based COVID-19 vaccines

Ironically, some vaccines need their own "boosters." Adding an ingredient called an adjuvant can help vaccines elicit a more robust immune response, better training the body to fight a pathogen.

1 Sep 2022

Study opens a window of opportunity to design RAF1 degraders against lung adenocarcinomas

One of the main challenges in oncology is the development of drugs against KRAS oncogenes. These oncogenes -genes that cause cancer when mutated - are responsible for a quarter of all human cancers, including the three tumor types with the highest mortality rates: lung adenocarcinoma, colorectal carcinoma and pancreatic ductal adenocarcinoma.

1 Sep 2022

Researchers identify how some cancer cells cheat treatment-induced cell death

Scientists at St. Jude Children's Research Hospital have identified how some cancer cells cheat treatment-induced cell death.

1 Sep 2022

Rutgers scientists design a synthetic protein that quickly detects molecules of deadly nerve agent

A team that includes Rutgers scientists has designed a synthetic protein that quickly detects molecules of a deadly nerve agent that has been classified by the United Nations as a weapon of mass destruction and could be used in a chemical warfare attack.

1 Sep 2022

Protein News and Research

Further Reading

'Rippled beta sheet' protein structure created and characterized using x-ray crystallography

How does ACE2 expression in target cells affect neutralization by antibodies to different spike epitopes?

What is currently known about immune responses to COVID-19 vaccines and cellular immune responses against SARS-CoV-2?

The origins, breadth, and resolution of autoreactivity in severe COVID-19

The effects of SARS-CoV-2 infection on antibody and B-cell responses to a third dose of mRNA vaccination

The dynamics of neutralizing antibodies in a cohort of children and adolescents after SARS-CoV-2 infection

A rapid and efficient method of identifying neutralizing nanobodies directed against SARS-CoV-2

Depletion of reactive astrocytes regresses glioblastoma

Researchers develop novel therapeutic strategy to treat Huntington's disease

CDC recommends Novavax's COVID-19 vaccine to be used as primary series option for adolescents

Study provides a comprehensive view of the genomics of all childhood ALL subtypes

New substance boosts the effect of protein-based COVID-19 vaccines

Study opens a window of opportunity to design RAF1 degraders against lung adenocarcinomas

Researchers identify how some cancer cells cheat treatment-induced cell death

Rutgers scientists design a synthetic protein that quickly detects molecules of deadly nerve agent

Inhibiting a key metabolic enzyme selectively kills melanoma cells and stops tumor growth

Simple blood test may identify patients at high risk of neurotoxic complications after CAR-T cell therapy

Researchers demonstrate improved culture of primate induced pluripotent stem cells

Intranasally delivered neutralizing antibody protects against SARS-CoV-2 Omicron and Delta variants

N501Y mutation and SARS-CoV-2 spike protein-angiotensin-converting enzyme-2 binding

Industry Focus eBook - Protein Analysis (3rd edition) eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo