Lungs News and Research

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Enrollment complete in Cerulean CRLX101 Phase 2 study for non-small cell lung cancer

Cerulean Pharma Inc., a leader in developing dynamically tumor-targeted nanopharmaceuticals, today announced that it has completed enrollment of a randomized Phase 2 study of its lead candidate, CRLX101, in advanced non-small cell lung cancer (NSCLC). The company also announced that it has dosed the first patient in a second tumor type.

2 Jul 2012

Blocking AXL protein may prevent resistance to lung cancer drug

People with lung cancer who are treated with the drug Tarceva face a daunting uncertainty: although their tumors may initially shrink, it's not a question of whether their cancer will return—it's a question of when. And for far too many, it happens far too soon.

2 Jul 2012

Smokers with COPD may find relief with cystic fibrosis drug

A drug developed to treat certain strains of cystic fibrosis may be useful in the treatment of chronic obstructive pulmonary disease, one of the most common lung diseases, which is seen frequently in smokers and has no cure. The findings were published online Friday, June 29, 2012 in the online journal PLoS ONE by researchers at the University of Alabama at Birmingham.

30 Jun 2012

Study details canonical Wnt signaling pathway

Many lung cancers are driven by mutations in the epidermal growth-factor receptor (EGFR), and so it makes sense that many successful modern treatments block EGFR activity. Unfortunately, cancers inevitably evolve around EGFR inhibition, and patients with lung cancers eventually relapse.

30 Jun 2012

ACR updates 39 appropriateness criteria topics and adds five new criteria

New and updated evidence-based guidelines to help health care providers choose the most appropriate medical imaging exam or radiation therapy for a patient's clinical condition are now available via the latest version of the American College of Radiology (ACR) Appropriateness Criteria.

29 Jun 2012

Inhibiting immune response during initial multi-drug therapy could speed TB treatment time

Inhibiting a key immune response in mice during initial multi-drug treatment for tuberculosis could - paradoxically - shorten treatment time for the highly contagious lung infection according to new research from Johns Hopkins Children's Center and the Center for TB Research.

29 Jun 2012

Flu immunity depends on number of viruses involved during initial infection

Not only does the type of flu virus affect a patient's outcome, but a new research report appearing in the Journal of Leukocyte Biology suggests that the number of viruses involved in the initial infection may be important too.

29 Jun 2012

UCLA Heart Transplant Program performs 2,000th heart transplant surgery

The UCLA Heart Transplant Program performed its 2,000th heart transplant surgery earlier this month, becoming the first program in the western United States and only the second in the world to achieve this remarkable milestone.

28 Jun 2012

Radiologists' efficiency can be improved using lung nodule matching program

An automated lung nodule matching program can improve radiologists' efficiency almost two-fold, a first of its kind study shows.

28 Jun 2012

Detailed study on how diesel soot gets stuck in the lungs

The exhaust from diesel-fuelled vehicles, wood fires and coal-driven power stations contains small particles of soot that flow out into the atmosphere. The soot is a scourge for the climate but also for human health. Now for the first time, researchers have studied in detail how diesel soot gets stuck in the lungs. The results show that more than half of all inhaled soot particles remain in the body.

28 Jun 2012

TB research finds body’s own response helps TB bacteria survive

Inhibiting a key immune response in mice during initial multi-drug treatment for tuberculosis could — paradoxically — shorten treatment time for the highly contagious lung infection according to new research from Johns Hopkins Children’s Center and the Center for TB Research. Shorter duration of drug therapy is key, researchers say, to increase treatment compliance for the growing global health threat posed by the disease.

28 Jun 2012

Touch important for side-effects of medicines for premature babies with respiratory problems

Discovering that touch is important for the side-effects of a medicine for premature babies with respiratory problems. This is what Sanne Claessens finds so fascinating about fundamental research in medical pharmacology. PhD defence 27 June.

28 Jun 2012

ACCP, OneBreath and COPD Alliance to unite on World Spirometry Day

The American College of Chest Physicians (ACCP), OneBreath, the COPD Alliance, and thousands of organizations worldwide will unite on World Spirometry Day, June 27, to promote lung health and elevate the status of often overlooked lung conditions, reinforcing the value of spirometry in the diagnosis of these conditions.

28 Jun 2012

Researchers design microparticles that can deliver oxygen quickly into the bloodstream

Patients unable to breathe because of acute lung failure or an obstructed airway need another way to get oxygen to their blood—and fast—to avoid cardiac arrest and brain injury. A team led by researchers at Boston Children's Hospital has designed tiny, gas-filled microparticles that can be injected directly into the bloodstream to quickly oxygenate the blood.

28 Jun 2012

Second potential immune checkpoint target for cancer immunotherapy announced by Compugen

Compugen Ltd. (NASDAQ: CGEN) announced today results demonstrating the therapeutic potential of CGEN-15022, a Compugen-discovered B7/CD28-like membrane protein, as an immune checkpoint target for treatment of multiple cancers.

27 Jun 2012

MAARA invests £340,000 into vital asthma and allergy research

A charity operating Britain's longest-running pollen database is investing over £340,000 into vital asthma and allergy research at the University of Leicester.

27 Jun 2012

Broken heart syndrome may protect the heart from adrenaline overload

A condition that temporarily causes heart failure in people who experience severe stress might actually protect the heart from very high levels of adrenaline, according to a new study published in the journal Circulation. The research provides the first physiological explanation for Takotsubo cardiomyopathy, also called "broken heart syndrome" because it affects people who suffer severe emotional stress after bereavement, and suggests guidance for treatment.

27 Jun 2012

Scientists discover new flu-fighting role for IL-15 protein

University of Georgia scientists have discovered a new flu-fighting role for a well-known component of the immune system. Kimberly Klonowski, assistant professor of cellular biology in the UGA Franklin College of Arts and Sciences, and her colleagues found that administering a cell-signaling protein known as IL-15 to mice infected with influenza reduces their peak viral load by nearly three times.

27 Jun 2012

Heavily congested highway correlates with higher rates of asthma

Researchers at SUNY Downstate Medical Center and Lutheran Medical Center in Brooklyn, New York, found that living near a heavily congested highway correlates with a higher presence of asthma.

27 Jun 2012

Sunshine Biopharma completes Adva-27a cytotoxicity study on multidrug-resistant lung cancer

Sunshine Biopharma Inc., a pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer, today announced that it has completed a cytotoxicity study of its lead compound, Adva-27a, in H69AR, a Multidrug Resistant Small Cell Lung Cancer cell line. Cytotoxicity studies measure the ability of a drug to destroy cancer cells in vitro.

27 Jun 2012