Cell Signaling News and Research

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Cell signaling is vital for cells to communicate and coordinate their activities, not just in the human body, but in all organisms. There are thousands of signaling pathways, ranging from protein homeostasis to carcinogenesis and biofilm formation.

Scientists identify new treatment to combat PFAPA syndrome in children

A preliminary study conducted by a team at the National Institutes of Health has identified a promising new treatment in children for the most common form of a rare disorder.

11 Apr 2011

ASBMB to honor 11 scientists with annual awards for biomedical research

The winners of the American Society for Biochemistry and Molecular Biology annual awards will give lectures at the Experimental Biology 2011 conference April 9-13 at the Walter E. Washington Convention Center in Washington, D.C.

8 Apr 2011

Lilly presents results of JAK2, Hedgehog inhibitor preclinical cancer studies at 102nd AACR

Eli Lilly and Company announced results today from two preclinical studies of molecules that target genetic mutations and disable specific signaling pathways that can lead to cancer. The studies evaluated two unique molecules – a JAK2 inhibitor and a Hedgehog inhibitor – with results presented during the American Association for Cancer Research (AACR) 102nd Annual Meeting in Orlando, Fla.

5 Apr 2011

University of Houston part of multi-investigator $5.2M CPRIT award for prostate cancer research

A pair of University of Houston (UH) researchers and their colleagues will begin work to develop new methods for treating the most severe form of prostate cancer thanks to $5.2 million in grants recently awarded by the Cancer Prevention and Research Institute of Texas (CPRIT).

2 Apr 2011

Researchers create new computational model to understand animal cell behavior

Biological systems, including cells, tissues and organs, can function properly only when their parts are working in harmony. These systems are often dauntingly complex: Inside a single cell, thousands of proteins interact with each other to determine how the cell will develop and respond to its environment.

24 Mar 2011

Cell receptor recycling mechanism discovery opens up new class of therapeutic targets

Prof. Manojkumar Puthenveedu of Carnegie Mellon University studies the mechanisms by which membrane trafficking controls and co-ordinates the complex signalling pathways in the brain. Despite the fact that almost all diseases can be traced to a defect in how cells respond to signals, little is known about how signalling pathways are maintained in normal cells and the changes that occur in abnormal conditions.

23 Mar 2011

Ventana, CST enter license agreement for personalized cancer diagnostics

Cell Signaling Technology, Inc. of Danvers, MA, announced today that it has granted Ventana Medical Systems, Inc., a worldwide non-exclusive license to CST patent rights and proprietary antibody reagents relating to the detection of epidermal growth factor receptor mutations for the field of tissue-based in vitro diagnostic testing.

From Cell Signaling Technology 16 Mar 2011

New animal model helps define molecular processes that lead to PA

Pilocytic astrocytoma is the most common pediatric brain tumor, and there are few medical therapies available to those patients for whom surgery is not curative.

15 Mar 2011

Researchers create protein molecule for new anti-inflammatory therapies

Researchers from across multiple disciplines at NYU Langone Medical Center created a new protein molecule derived from the growth factor progranulin may provide the basis for new therapies in inflammatory diseases, such as rheumatoid arthritis, according to a study published in the March 10, 2011 issue of Science.

11 Mar 2011

Novel sortase-based techniques allow modification of a large variety of different proteins

Whitehead Institute scientists have created a method that site-specifically modifies proteins to exert control over their properties when administered therapeutically. The technique should be useful to increase potency, slow metabolism, and improve thermal stability of therapeutically useful proteins, such as interferon alpha 2 (IFN-alpha 2), which is used to treat variety of diseases, including leukemia, melanoma, and chronic hepatitis C.

10 Mar 2011

Scientists develop new method that uncovers combined effects of genes

Scientists at the European Molecular Biology Laboratory and the German Cancer Research Centre, both in Heidelberg, Germany, have developed a new method that uncovers the combined effects of genes.

8 Mar 2011

Researchers identify gene behind self-healing skin cancer

Cancer Research UK scientists have discovered the gene behind a rare skin cancer which grows rapidly for a few weeks before healing spontaneously, according to research published in Nature Genetics.

28 Feb 2011

CST, Astellas Pharma enter commercialization partnership for cancer diagnostic, therapeutic products

Cell Signaling Technology, Inc. of Danvers, MA announced today a joint commercialization partnership with Astellas Pharma, Inc. of Tokyo, Japan focused on the delivery of personalized cancer therapeutics and diagnostics.

From Cell Signaling Technology 24 Feb 2011

Mutated cancer pathway studies identify therapeutic targets for congenital heart disease

Cross-disciplinary teams of scientists studying genetic pathways that are mutated in many forms of cancer, but which also cause certain forms of congenital heart disease - including hypertrophic cardiomyopathy, a thickening of the heart muscle that is the leading cause of sudden death in children and young adults -, have introduced these mutations into mice and successfully treated HCM in the lab.

22 Feb 2011

New research: Reovirus infected melanoma cells secrete proteins that can kill cancer

Reoviruses are successfully being used in clinical trials to treat patients with cancer. Not only does the virus cause cancer cells to die, it also forces them to release pro-inflammatory chemokines and cytokines, which in turn causes the patient's immune system to attack the disease.

21 Feb 2011

Scientists develop novel treatment strategy for multiple myeloma

Scientists at Virginia Commonwealth University Massey Cancer Center have developed a novel treatment strategy for multiple myeloma that pairs two targeted agents to kill cancer cells. The study's findings, published in today's edition of the journal "Blood," are the first to demonstrate the synergistic, anti-myeloma effects of this combination regimen both in vitro and in vivo.

11 Feb 2011

Baden-W-rttemberg's study and research to be presented at AAAS Annual Meeting 2011

Baden-W-rttemberg, the German Southwest, is the most innovative region in Europe, particularly dedicated to science and education. A share of 4.4 % of the State's GDP is invested in research and development - more than in most countries all around the world. Baden-W-rttemberg offers the highest density of research institutions and universities in Germany.

7 Feb 2011

Technique that cleared mouse of HIV-like virus sparks hope for new therapy

In a breakthrough, Australian researchers have developed a method to boost the immune system. This technique is seen to be capable of clearing an “HIV-like” infection from a mouse. This could in future lead to a cure for HIV and other chronic viral infections in humans. The findings from Melbourne’s Walter and Eliza Hall Institute are centred on a naturally occurring cell signalling hormone called interleukin-7 (IL-7).

6 Feb 2011

Cell signaling hormone boosts immune response to clear HIV-like infection

Australian scientists have successfully cleared a HIV-like infection from mice by boosting the function of cells vital to the immune response.

4 Feb 2011

Scientists unravel mystery about how new tumors in individuals with breast cancer take root

In a discovery that may lead to a new treatment for breast cancer that has spread to the bone, a Princeton University research team has unraveled a mystery about how these tumors take root.

4 Feb 2011

Cell Signaling News and Research

Further Reading

Scientists identify new treatment to combat PFAPA syndrome in children

ASBMB to honor 11 scientists with annual awards for biomedical research

Lilly presents results of JAK2, Hedgehog inhibitor preclinical cancer studies at 102nd AACR

University of Houston part of multi-investigator $5.2M CPRIT award for prostate cancer research

Researchers create new computational model to understand animal cell behavior

Cell receptor recycling mechanism discovery opens up new class of therapeutic targets

Ventana, CST enter license agreement for personalized cancer diagnostics

New animal model helps define molecular processes that lead to PA

Researchers create protein molecule for new anti-inflammatory therapies

Novel sortase-based techniques allow modification of a large variety of different proteins

Scientists develop new method that uncovers combined effects of genes

Researchers identify gene behind self-healing skin cancer

CST, Astellas Pharma enter commercialization partnership for cancer diagnostic, therapeutic products

Mutated cancer pathway studies identify therapeutic targets for congenital heart disease

New research: Reovirus infected melanoma cells secrete proteins that can kill cancer

Scientists develop novel treatment strategy for multiple myeloma

Baden-W-rttemberg's study and research to be presented at AAAS Annual Meeting 2011

Technique that cleared mouse of HIV-like virus sparks hope for new therapy

Cell signaling hormone boosts immune response to clear HIV-like infection

Scientists unravel mystery about how new tumors in individuals with breast cancer take root

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

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