Polio News and Research

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Poliomyelitis (polio) is a highly infectious disease caused by a virus that invades the nervous system and can cause severe paralysis. The virus enters the body through the mouth and multiplies in the intestine. Initial symptoms are fever, fatigue, headache, vomiting, stiffness in the neck, and pain in the limbs. One in 200 infections leads to irreversible paralysis (usually in the legs). Among those paralyzed, 5-10% die when their breathing muscles become immobilized. Polio mainly affects children under five years of age. Naturally occurring polio was eliminated in the U.S. in 1979 and in the Western Hemisphere by 1991; however, worldwide efforts are continuing towards eradication of this contagious and devastating disease.

Deactivation of CRTC1 protein increases lifespan

Substantial evidence suggests that lifespan is increased if an organism restricts its daily calorie intake, a spartan regime that some say works by just making life seem longer. A team of scientists from the Salk Institute of Biological Studies has discovered a molecular switch flipped by hunger that could not only make longevity more appetizing but identify drug targets for patients with aging-related diseases such as type II diabetes or cancer.

17 Feb 2011

Obama's 2012 budget proposal requests boost for GHI funding, slight core budget increases for State, USAID

President Barack Obama "released his budget proposal for fiscal year 2012 on Monday," the New York Times reports. The president's "fiscal 2012 budget allocates $47 billion for the State Department and the U.S. Agency for International Development, which reflects only a 1 percent increase over 2010 levels for the core budget," National Journal writes.

16 Feb 2011

Opinions: U.S. foreign aid; Polio eradication

"Over the past few weeks, I've had a chance to interview some amazing people," ranging from Bill Gates to scientists and teachers, who are all concerned about impending budget cuts, the New York Times' David Brooks writes in a column. Brooks explains that the "coming budget cuts have nothing to do with merit. They have to do with the inexorable logic of mathematics."

14 Feb 2011

Global Health Consortium to support development of vaccines to control dengue fever

The International Vaccine Institute today announced the launch of the Dengue Vaccine Initiative, in collaboration with the Sabin Vaccine Institute, the Johns Hopkins University, and the World Health Organization, to support development of vaccines to control dengue fever, a widespread and expanding hemorrhagic fever that is endemic in most tropical and subtropical regions of the world.

10 Feb 2011

Opinions: Polio vaccines; Alternatives to DDT, insecticides; Food price volatility; Global poverty; Foreign aid for vaccines

"No one denies" that the oral polio vaccine "has considerable merits. It's cheap to make. It's easy to administer; you don't need a trained nurse with a clean syringe [like the inactive vaccine needs], just a volunteer with a dropper. And it gives excellent immunity. ... But there are problems with the method," Wendy Orent, author of the book Plague: The Mysterious Past and Terrifying Future of the World's Most Dangerous Disease, writes in a Los Angeles Times opinion piece.

10 Feb 2011

Salk Institute receives $2.3 million CIRM grant for translational research on Parkinson's disease

The Salk Institute has been awarded a $2.3 million grant by the California Institute for Regenerative Medicine for translational research focusing on developing a novel stem cell based therapy for Parkinson's disease.

4 Feb 2011

Bill Gates' annual letter calls for focus on eradicating polio, governments to sustain foreign aid

Bill Gates, co-chair of the Bill & Melinda Gates Foundation, "urged developed nations to help him wipe out polio 'once and for all' at an event to release his third annual letter [.pdf] Monday," Agence France-Presse reports.

2 Feb 2011

Public services supporting California's low-income, disabled elderly is fragile, says study

The network of public services that supports California's low-income, disabled elderly is fragile, affecting the ability of these vulnerable residents to live independent lives in their own homes, according to a new study from the UCLA Center for Health Policy Research.

1 Feb 2011

Bill Gates argues the case for polio eradication and expanded childhood immunization

Bill Gates, co-chair of the Bill & Melinda Gates Foundation, argues the case for polio eradication and expanded childhood immunization in his third annual letter released today. The letter, a personal account of his priorities, also calls on governments to invest in foreign aid, even in the face of a tough economic climate.

1 Feb 2011

U.K., Gates Foundation announce extra funding for global polio eradication as WEF wraps up

U.K. Prime Minister David Cameron and Bill Gates, co-chair of the Bill & Melinda Gates Foundation, on Friday at the World Economic Forum (WEF) in Davos, Switzerland, announced "extra financing for polio eradication, easing a shortfall in funding that hinders a global effort to stop the crippling virus," Bloomberg reports.

1 Feb 2011

Research shows nestin regulates formation of neuromuscular junction

In a study published in the Jan. 30, 2011, advance online edition of Nature Neuroscience, Salk Institute of Biological Studies investigators led by Kuo-Fen Lee, PhD., show that nestin has reason for being in a completely different cell type--muscle tissue.

30 Jan 2011

Initiative to eliminate polio in the U.K.

British Prime Minister David Cameron said today that the United Kingdom would double its current contribution to polio eradication.

29 Jan 2011

UK government, Bill & Melinda Gates Foundation to support efforts to stamp out polio

British Prime Minister David Cameron said today that the United Kingdom would double its current contribution to polio eradication.

29 Jan 2011

Clinton, other speakers discuss poverty, development issues at World Economic Forum

"Poverty and unemployment reared their heads at the World Economic Forum on Thursday, with speakers urging the elite audience to bridge a growing gap between booming multinationals and the jobless poor," Reuters reports.

29 Jan 2011

Bill Gates, crown prince of Abu Dhabi announce $100m pledge for vaccines for Afghan, Pakistani children

Bill Gates, co-chair of the Bill & Melinda Gates Foundation, and Sheikh Mohammed bin Zayed al-Nahayanm, the crown prince of Abu Dhabi, "pledged $100 million Wednesday to deliver vaccines to children in Afghanistan and Pakistan," Reuters reports.

28 Jan 2011

Lancet series examines health issues facing populations in Southeast Asia

"Southeast Asia's 600 million people are facing a raft of new health challenges as the disaster-prone region undergoes some of the world's fastest social change," according to a series of papers and commentary pieces, published Tuesday in the Lancet, Agence France-Presse reports (O'Brien, 1/25).

27 Jan 2011

APIC announces initiative to eliminate central line-associated bloodstream infections

The Association for Professionals in Infection Control and Epidemiology today announced a major initiative to eliminate one of the most preventable and deadly infections that patients can acquire in healthcare facilities: central line-associated bloodstream infections, which kill 30,000 people in the U.S. every year.

25 Jan 2011

Glioblastoma's molecular flexibility helps resist nearly all treatment efforts

Glioblastoma, the most common and lethal form of brain cancer and the disease that killed Massachusetts Senator Ted Kennedy, resists nearly all treatment efforts, even when attacked simultaneously on several fronts. One explanation can be found in the tumor cells' unexpected flexibility, discovered researchers at the Salk Institute for Biological Studies.

25 Jan 2011

Opinions: GAVI; Haitian women; Clinton's foreign policy

"Vaccines are among the greatest scientific contributions to human welfare. They are also some of the largest humanitarian contributions of developed nations to the rest of the world. So it is unfortunate that a decade of vaccine controversy has overshadowed a decade of vaccine miracles," Washington Post columnist Michael Gerson writes in an opinion piece reflecting on the contributions of the GAVI Alliance over the past decade.

21 Jan 2011

WHO Director-General expresses concern over public mistrust of vaccines

During the WHO's executive board meeting Monday, WHO Director-General Margaret Chan expressed concerns over what she called a "'worrisome' public mistrust of vaccines, following signs of a tail-off in flu vaccination," Agence France-Presse reports (1/18).

20 Jan 2011

Polio News and Research

Further Reading

Deactivation of CRTC1 protein increases lifespan

Obama's 2012 budget proposal requests boost for GHI funding, slight core budget increases for State, USAID

Opinions: U.S. foreign aid; Polio eradication

Global Health Consortium to support development of vaccines to control dengue fever

Opinions: Polio vaccines; Alternatives to DDT, insecticides; Food price volatility; Global poverty; Foreign aid for vaccines

Salk Institute receives $2.3 million CIRM grant for translational research on Parkinson's disease

Bill Gates' annual letter calls for focus on eradicating polio, governments to sustain foreign aid

Public services supporting California's low-income, disabled elderly is fragile, says study

Bill Gates argues the case for polio eradication and expanded childhood immunization

U.K., Gates Foundation announce extra funding for global polio eradication as WEF wraps up

Research shows nestin regulates formation of neuromuscular junction

Initiative to eliminate polio in the U.K.

UK government, Bill & Melinda Gates Foundation to support efforts to stamp out polio

Clinton, other speakers discuss poverty, development issues at World Economic Forum

Bill Gates, crown prince of Abu Dhabi announce $100m pledge for vaccines for Afghan, Pakistani children

Lancet series examines health issues facing populations in Southeast Asia

APIC announces initiative to eliminate central line-associated bloodstream infections

Glioblastoma's molecular flexibility helps resist nearly all treatment efforts

Opinions: GAVI; Haitian women; Clinton's foreign policy

WHO Director-General expresses concern over public mistrust of vaccines

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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