Signaling Pathway News and Research

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Researchers identify genetic mutation that causes idiopathic pulmonary fibrosis

Researchers in Japan have identified a genetic mutation that causes a severe lung disease called idiopathic pulmonary fibrosis by killing the cells lining the lung's airways.

10 Oct 2019

New understanding of breast cancer metastasis to bone

In breast cancer patients with metastatic disease, bone is the most common site of metastasis and the most common site of first distant relapse, with roughly half (48%) of breast cancer patients developing bone metastases after treatment.

8 Oct 2019

GW researchers show connection between bacteria in the microbiome and colon cancer

A mutant protein found in humans with colon cancer blocks a pathway that regulates proliferation and expansion of cells, increasing amounts of bacterial species associated with the development of colon cancer.

4 Oct 2019

Researchers identify new targets to treat fibrotic diseases

When it comes to repairing injured tissue, specialized cells in the body known as fibroblasts are called into action. Fibroblasts give rise to healing cells called myofibroblasts, which generally is good in the short term - but bad when myofibroblast activation gets out of hand.

4 Oct 2019

Study may help in personalizing treatment for lung cancer, develop new drugs

Researchers at the University of Copenhagen have used highly sophisticated molecular analyses to identify key proteins in the signaling pathways that cancers use to spread in the body.

4 Oct 2019

New mechanism that controls DNA repair identified

Deoxyribonucleic acid (DNA), is the macromolecule that holds all hereditary and genetic information. Continuously under assault, alterations and damage to DNA can lead to many different health issues, including cancer.

2 Oct 2019

Researchers identify new genetic signals for regulation of infant growth

Researchers at the University of Bergen in Norway have identified new genetic signals for the regulation of how infants grow. This may be a crucial step in the fight against growth-related diseases.

1 Oct 2019

Study may help scientists to learn more about the causes of chronic pain

Researchers from North Carolina State University have found that inflammation increases neuronal activity, gene expression and sensory nerve (neurite) outgrowth in neurons involved in thermal - but not physical- sensations in mice.

27 Sep 2019

Arthritis drug could be used to treat lichen planus skin rash

Constant itchy, painful bumps, scaly arms and legs, and damaged nails make lichen planus an inflammatory skin disease that's both frustrating and painful for patients trying to keep their quality of life.

26 Sep 2019

Mystery underlying cardiac toxicity caused by diabetes drugs solved

Like catching two fish with one worm, treating two problems with a single drug is efficient, but exceedingly difficult.

25 Sep 2019

Leukemia drug appears to be effective in treating deadly pediatric brain tumor

A drug used to treat chronic myeloid leukemia appears to be more effective at stopping a type of medulloblastoma in mouse models than existing treatments for the deadly pediatric brain tumor, reports a multi-institutional team led by researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego.

21 Sep 2019

Researchers discover potential approach to treating diabetic retinopathy

Boston University researchers have identified an enzymatic precursor that is toxic to retinal cells and could be used in new treatments for diabetic retinopathy.

20 Sep 2019

Scientists identify pathway for treatment-resistant lung cancer

A big way chemotherapy works is by prompting cancer cells to commit suicide, and scientists have found a pathway the most common lung cancer walks to avoid death.

20 Sep 2019

NMDAR receptor is responsible for breast-to-brain metastases, shows study

In 2018, breast cancer was the most common cancer in women worldwide, accounting for about a quarter of all reported cancers. One of the biggest problems with any type of cancer is metastasis; and when breast cancer metastasizes, the brain is a common destination.

19 Sep 2019

Metastatic colorectal cancer patients with certain BRAF mutations may respond to anti-EGFR therapy

Patients with metastatic colorectal cancer harboring a subset of non-V600 mutations in the BRAF gene, known as class 3 BRAF mutations, were more likely to respond to anti-EGFR treatment.

12 Sep 2019

Researchers develop new cocktail of drugs that shrink pancreatic tumors

Cancer is relentless and resilient. When a drug blocks a cancer cell's main survival pathway, the cell avoids the obstacle by taking different pathways or detours to save itself. This tactic is called "developing resistance," and it's one of the key challenges researchers face when seeking effective therapeutics to combat pancreatic ductal adenocarcinoma (PDA).

9 Sep 2019

Researchers discover a molecule that regulates tumor development in different types of cancers

Researchers from the Josep Carreras Leukemia Research Institute, discover that a non-coding region of the genome originates a key molecule for the proliferation of tumors in breast cancer and some types of sarcoma.

5 Sep 2019

Breast cancer gene could be key to developing targeted therapy for hepatoblastoma

Hepatoblastoma is a rare form of liver cancer affecting just a few individuals per million. However, it is the leading cause of liver cancer in infants and young children, with most patients diagnosed before their third birthday.

4 Sep 2019

Danish-American researchers find new way to treat chronic inflammation

Researchers from Aarhus University Hospital and Aarhus University in Denmark in collaboration with researchers from Colorado in the United States have found a new way to treat the inflammation involved in chronic diseases such as psoriasis, asthma and HIV.

30 Aug 2019

New molecules that could help tackle tooth loss and regeneration discovered

Our teeth take thousands of bites per day, and understanding exactly what holds them in place and how is key to helping people live with their own teeth for longer.

30 Aug 2019