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Yale study identifies racial and ethnic disparities in Oncotype DX testing for women with breast cancer

In a simple definition, cancer is a disease of the cells, which is caused by gene mutations. For a proportion of patients, including women with hormone receptor positive (HR+) breast cancer, gene expression profiling has a substantial impact on treatment decision-making by determining which patients might—or might not—respond to particular treatment options.

17 Mar 2017

Tulane researcher aims to improve hormone replacement therapy for post-menopausal women

New research at the Tulane School of Medicine is looking at an estrogen receptor that could be a site for targeted hormone replacement therapy in post-menopausal women.

16 Mar 2017

Researchers identify underlying cause of obsessive-compulsive disorder

An overactive molecular signal pathway in the brain region of the amygdala can lead to obsessive-compulsive disorder (OCD). A research team from Würzburg has established this connection.

16 Mar 2017

Blocking hypocretin signaling may provide new avenue for treating cocaine addiction, study suggests

The hypocretin/orexin (HCRT) system of the brain is best known for promoting wakefulness and appetite. A new paper in Biological Psychiatry suggests that blocking hypocretin signaling via the HCRT-1 receptor (HCRT-R1) might also reduce the appetite for cocaine.

16 Mar 2017

Scientists create first model of anorexia nervosa using iPSCs derived from adolescent females

An international research team, led by scientists at University of California San Diego School of Medicine, has created the first cellular model of anorexia nervosa (AN), reprogramming induced pluripotent stem cells (iPSCs) derived from adolescent females with the eating disorder.

14 Mar 2017

Heroin use linked to epigenetic alterations in the brain

The past few years have seen an explosion of heroin abuse and deaths from opiate overdose. But little is known about the molecular underpinnings of heroin addiction.

14 Mar 2017

New approach shows promise to prevent, treat cholesterol gallstone disease

According to current estimates, 20 to 25 million Americans have or will develop gallstones, representing almost 15% of adults. Although only a small percentage of individuals with gallstones develop symptoms, more than 700,000 individuals annually undergo surgical gallbladder removal and many more take medications to manage the condition or undergo stone-dissolving procedures.

13 Mar 2017

Evolution of immuno-oncology

Immuno-oncology did not exist four years ago, it's a term coined by Dr. Axel Hoos, Head of the newly defined immuno-oncology department at GSK. He is also Senior Vice President Therapeutic Area (TA) and Head for Oncology R&D. Previously, it was referred to as cancer immunotherapy, but now it is called immuno-oncology (IO).

13 Mar 2017

Mayo study provides vital information on tumor sequencing in newly diagnosed breast cancer patients

Tumor sequencing is increasingly used to select treatment for patients with cancer, but its role in women with newly diagnosed breast cancer is unknown.

13 Mar 2017

Endostatin can decrease proliferation of castration-resistant prostate cancer cells

Failure of hormone deprivation therapy, which is used to slow prostate cancer in patients, leads to castration-resistant prostate cancer, a lethal form of advanced disease with limited treatment options.

10 Mar 2017

New clinical study to test promising diabetes drug in people with MND

A diabetes drug could one day be used to treat neurodegenerative diseases like Motor Neurone Disease (MND), Alzheimer's and Parkinson's.

10 Mar 2017

Study shows how socially contagious itching is hardwired in the brain

Some behaviors — yawning and scratching, for example — are socially contagious, meaning if one person does it, others are likely to follow suit. Now, researchers at Washington University School of Medicine in St. Louis have found that socially contagious itching is hardwired in the brain.

10 Mar 2017

Study identifies therapeutic target for diabetic retinopathy

Specific cells in the retina trigger inflammation and vision impairment associated with diabetes, according to new research out of Case Western Reserve University School of Medicine.

9 Mar 2017

Scientists pinpoint key biological mechanism that can prevent proliferation of insulin-producing cells

If you become resistant to insulin, a condition that is a precursor to type 2 diabetes, your body tries to compensate by producing more of the "beta" cells in the pancreas that produce the critical hormone.

9 Mar 2017

TSRI researchers develop new drug candidates to target prostate and triple negative breast cancers

Scientists on the Florida campus of The Scripps Research Institute (TSRI) have designed two new drug candidates to target prostate and triple negative breast cancers.

9 Mar 2017

Hormone secreted by bone cells can suppress appetite, mice study reveals

A hormone secreted by bone cells can suppress appetite, according to mouse studies conducted by Columbia University Medical Center researchers.

8 Mar 2017

Scientists create synthetic cellular communications system that can respond to pain relief signals

Scientists from Manchester and Bristol have successfully created a synthetic cellular communications system - which has successfully recognised signals involved in pain relief.

From The University of Manchester 7 Mar 2017

SLU study findings suggest new method to suppress LDL cholesterol

In a paper published in Biochemical Pharmacology, Saint Louis University researchers examined the way a nuclear receptor called REV-ERB is involved in regulating cholesterol metabolism.

6 Mar 2017

Isoflavone consumption linked to decrease in mortality for some breast cancer patients

An epidemiological analysis of data from more than 6,000 American and Canadian women with breast cancer finds that post-diagnosis consumption of foods containing isoflavones—estrogen-like compounds primarily found in soy food—is associated with a 21 percent decrease in all-cause mortality.

6 Mar 2017

Dietary soy products could be safe, beneficial for women diagnosed with breast cancer

New research indicates that dietary soy products are safe and even beneficial for women diagnosed with breast cancer. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings may help resolve controversies over soy's potential link to breast cancer outcomes.

6 Mar 2017

Receptor News and Research

Yale study identifies racial and ethnic disparities in Oncotype DX testing for women with breast cancer

Tulane researcher aims to improve hormone replacement therapy for post-menopausal women

Researchers identify underlying cause of obsessive-compulsive disorder

Blocking hypocretin signaling may provide new avenue for treating cocaine addiction, study suggests

Scientists create first model of anorexia nervosa using iPSCs derived from adolescent females

Heroin use linked to epigenetic alterations in the brain

New approach shows promise to prevent, treat cholesterol gallstone disease

Evolution of immuno-oncology

Mayo study provides vital information on tumor sequencing in newly diagnosed breast cancer patients

Endostatin can decrease proliferation of castration-resistant prostate cancer cells

New clinical study to test promising diabetes drug in people with MND

Study shows how socially contagious itching is hardwired in the brain

Study identifies therapeutic target for diabetic retinopathy

Scientists pinpoint key biological mechanism that can prevent proliferation of insulin-producing cells

TSRI researchers develop new drug candidates to target prostate and triple negative breast cancers

Hormone secreted by bone cells can suppress appetite, mice study reveals

Scientists create synthetic cellular communications system that can respond to pain relief signals

SLU study findings suggest new method to suppress LDL cholesterol

Isoflavone consumption linked to decrease in mortality for some breast cancer patients

Dietary soy products could be safe, beneficial for women diagnosed with breast cancer

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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