Mutation News and Research

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Scientists identify promising strategy for HIV vaccine design

HIV has eluded vaccine-makers for thirty years, in part due to the virus' extreme ability to mutate. Physical scientists and clinical virologists from the Massachusetts Institute of Technology (MIT) and the Ragon Institute in Cambridge, Mass., have identified a promising strategy for vaccine design using a mathematical technique that has also been used in problems related to quantum physics, as well as in analyses of stock market price fluctuations and studies of enzyme sequences.

24 Feb 2012

MRSA strain in food animals concerns experts

The strain of staph, known as methicillin-resistant Staphylococcus aureus, or MRSA CC398, most often infects farm workers who come in contact with infected pigs, turkeys, or cows. Now the strain of bacteria has been found in about half of meat samples taken throughout the country. The researchers say that the indiscriminate use of antibiotics in livestock used for food is to blame for the infection's drug resistance.

23 Feb 2012

Vemurafenib nearly doubles survival for patients with metastatic melanoma

Investigators from Vanderbilt-Ingram Cancer Center (VICC) and 12 other centers in the United States and Australia have found that a new drug for patients with metastatic melanoma nearly doubled median overall survival.

23 Feb 2012

Study examines abdomyosarcoma growth in mouse models of muscular dystrophy

Inflammation, cell division and cell differentiation that occur during skeletal muscle regeneration may provide an ideal environment for the highly malignant tumor, rhabdomyosarcoma to arise. These are the findings from a Nationwide Children's Hospital study that examined rhabdomyosarcoma growth in mouse models of muscular dystrophy.

23 Feb 2012

First molecular evidence links body's natural circadian rhythms to SCD

A fundamental discovery reported in the March 1st issue of the journal Nature, uncovers the first molecular evidence linking the body's natural circadian rhythms to sudden cardiac death (SCD). Ventricular arrhythmias, or abnormal heart rhythms, are the most common cause of sudden cardiac death: the primary cause of death from heart disease.

23 Feb 2012

Study reveals how mutation shuts down DJ-1 protein's neuroprotective abilities

Purdue University researchers revealed how a mutation in a protein shuts down a protective function needed to prevent the death of neurons in Parkinson's disease, possibly opening the door to new drug strategies to treat the disorder.

22 Feb 2012

Electronic properties of DNA can play a role in early diagnosis of cancer-causing mutations

Scientists have discovered that cancer-causing genetic mutations have better-disguised electronic signatures than other mutations - a trait which could help them fly under the radar of the body's defence mechanisms.

22 Feb 2012

Key regulator of lens development also controls mechanosensory neuron development

A gene known to control lens development in mice and humans is also crucial for the development of neurons responsible for mechanosensory function, as neurobiologists of the Max Delbr-ck Center for Molecular Medicine (MDC) Berlin-Buch have now discovered.

22 Feb 2012

Tasmanian devil cancer genome mapped

Researchers, including those from Wellcome Trust Sanger Institute near Cambridge, have sequenced the genome of a facial cancer that is threatening the existence of the Tasmanian devil.

21 Feb 2012

Biotech company defends patent on gene mutation for breast cancer

A US biotechnology company is defending the granting of a controversial patent over a common genetic mutation for breast cancer, rejecting accusations it amounts to the privatization of the human body.

21 Feb 2012

Researchers discover identical antibiotic resistant genes in soil bacteria and in pathogens from clinics

Disease-causing bacteria's efforts to resist antibiotics may get help from their distant bacterial relatives that live in the soil, new research at Washington University School of Medicine suggests.

21 Feb 2012

Deadly flu virus research may be published for the advancement of science but more risk assessment needed says WHO

According to the World Health Organization, the two controversial studies that explain how scientists mutated the H5N1 bird flu virus into a form that could cause a deadly human pandemic will be published only after experts fully assess the risks.

20 Feb 2012

EC approves Plexxikon's Zelboraf to treat BRAF mutation-positive MM

Plexxikon Inc., a member of Daiichi Sankyo Group, today announced that the European Commission has approved Zelboraf (vemurafenib) for the monotherapy treatment of adult patients with BRAFV600 mutation-positive unresectable or metastatic melanoma.

20 Feb 2012

Study identifies USP15 as a critical protein in cancer

After years studying the molecular bases of glioblastoma - the most common brain tumor and one of the most aggressive of all cancers, the group led by Dr. Joan Seoane , Director of Translational Research at the Vall d'Hebron Institute of Oncology (VHIO) and ICREA Research Professor has today published a study in Nature Medicine identifying USP15 as a critical protein in cancer which, thanks to its molecular characteristics, shows enormous therapeutic promise.

20 Feb 2012

Defects in GPR120 protein may lead to obesity and liver disease

Defects in a protein that functions as a dietary fat sensor may be a cause of obesity and liver disease, according to a study published in the journal Nature, led by researchers at Imperial College London. The findings highlight a promising target for new drugs to treat obesity and metabolic disorders.

19 Feb 2012

Evolution of cancer genome to be discussed at 2012 AAAS annual meeting

Professor Mike Stratton, Director of the Wellcome Trust Sanger Institute, will speak about 'the evolution of the cancer genome' at the prestigious 2012 American Association for the Advancement of Science annual meeting. The AAAS annual meeting is one of the world's most widely recognized science events.

19 Feb 2012

RAD51 gene behind the cause of congenital mirror movements

Further work carried out on mice suggests that this gene plays a part in motor network cross-over. Cross-over is a key factor in the transmission of brain signals, because it allows the right side of the brain to control the left side of the body and vice versa. This research has been published in The American Journal of Human Genetics.

18 Feb 2012

Evolutionary biologist receives LRI grant for lupus research

Evolutionary biologist Harmit Singh Malik, Ph.D., of Fred Hutchinson Cancer Research Center, has received a $300,000 grant from the Lupus Research Institute to study the potential role of "genetic conflicts" in the development of lupus, an autoimmune disease.

18 Feb 2012

Scientists discover molecular pathway by which maternally inherited deafness appears to occur

Yale scientists have discovered the molecular pathway by which maternally inherited deafness appears to occur: Mitochondrial DNA mutations trigger a signaling cascade, resulting in programmed cell death.

17 Feb 2012

New potential strategy for KRAS-mutant colon cancers

Researchers from the Massachusetts General Hospital (MGH) Cancer Center have identified a new potential strategy for treating colon tumors driven by mutations in the KRAS gene, which usually resist both conventional and targeted treatments.

17 Feb 2012