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Precise inactivation of neurotransmitter receptors using CALI technique erases fear memory in mice

The delivery of chemical messenger (neurotransmitter) receptors to the junctions between nerve cells (synapses) is crucial to cognitive processes such as memory.

23 Feb 2017

Study shows how variations in receptor genes may lead to obsessive-compulsive disorder traits

A new Northwestern Medicine study found evidence suggesting how neural dysfunction in a certain region of the brain can lead to obsessive and repetitive behaviors much like obsessive-compulsive disorder.

22 Feb 2017

Study finds biochemical pathway that triggers regrowth of breast cancer stem cells after chemotherapy

Working with human breast cancer cells and mice, researchers at Johns Hopkins say they have identified a biochemical pathway that triggers the regrowth of breast cancer stem cells after chemotherapy.

22 Feb 2017

UAB researchers developing new peptide that may help combat familial hypercholesterolemia

Researchers at the University of Alabama at Birmingham are developing and testing a new peptide that they hope will lead to better treatment options for familial hypercholesterolemia.

22 Feb 2017

Gene expression patterns could help predict treatment for breast cancer, research shows

A Michigan State University breast cancer researcher has shown that effective treatment options can be predicted based on the way certain breast cancer genes act or express themselves.

21 Feb 2017

Compound from snail's venom may offer alternative to opioids for pain relief

A tiny snail may offer an alternative to opioids for pain relief. Scientists at the University of Utah have found a compound that blocks pain by targeting a pathway not associated with opioids.

21 Feb 2017

EPFL scientists develop new computer model for better design of allosteric drugs

EPFL scientists have created a new computer model that can help better design of allosteric drugs, which control proteins "at a distance".

21 Feb 2017

Penn researchers find new way to track rare T cells in blood after annual flu vaccine

For most vaccines to work the body needs two cell types - B cells and T helper cells - to make antibodies. B cells are the antibody factories and the T helper cells refine the strength and accuracy of antibodies to home and attack their targets.

20 Feb 2017

SLU scientist examines potential biomarkers for pain linked to debilitating health conditions

With new funding from The Mayday Fund, a Saint Louis University researcher will leverage her discovery of a pain pathway to determine if either of two key molecules can be used as biomarkers for pain associated with four debilitating health conditions: chemotherapy-induced peripheral neuropathy, endometriosis, interstitial cystitis and vulvodynia.

16 Feb 2017

Study identifies protein in tumor microenvironment that promotes breast cancer spread

To understand what makes breast cancer spread, researchers are looking at where it lives - not just its original home in the breast but its new home where it settles in other organs. What's happening in that metastatic niche where migrated cancer cells are growing?

16 Feb 2017

New research provides clues to how antibody treatment led to remission in SIV-infected monkeys

Scientists at the National Institutes of Health have found that the presence of the protein alpha-4 beta-7 integrin on the surface of HIV and its monkey equivalent--simian immunodeficiency virus, or SIV--may help explain why an antibody protected monkeys from SIV in previous experiments.

16 Feb 2017

Mice study shows how WAVE1 protein regulates the brain's response to cocaine

Cocaine is one of the most addictive substances known to man, and for good reason: By acting on levels of the "feel-good" chemical dopamine, it produces a tremendous sensation of euphoria.

15 Feb 2017

Two-drug combination shows promise against diabetic retinopathy in animal models

A two-drug cocktail provided better protection against diabetes-related vision loss than a single drug during testing in rat models, a team of University of Florida Health and Dutch researchers has found.

15 Feb 2017

Researchers pinpoint new neural mechanism that regulates chronic stress response

In addition to the classic stress response in our bodies - an acute reaction that gradually abates when the threat passes - our bodies appear to have a separate mechanism that deals only with chronic stress.

15 Feb 2017

Only subset of mother's HIV virus infects infants during pregnancy or breastfeeding, research shows

In the transmission of HIV-1 from mother to child only a subset of a mother's viruses infects their infants either in utero or via breastfeeding, and the viruses that are transmitted depend on whether transmission occurs during pregnancy or through breastfeeding, according to UCLA-led research.

15 Feb 2017

Research opens treatment pathways for cancers that do not respond to targeted antibodies

By hijacking a cancer cell's own metabolism, researchers have found a way to tag and target elusive cancers with small-molecule sugars. This opens treatment pathways for cancers that are not responsive to conventional targeted antibodies, such as triple-negative breast cancer.

15 Feb 2017

Researchers explore role played by nicotine in grouping of nicotinic receptors within the brain

Nicotine -- the primary compound found within tobacco smoke -- is known to change the grouping of some subtypes of nicotinic receptors, but the mechanisms for nicotine addiction remain unclear.

15 Feb 2017

New infusion therapy may help avoid debilitating symptoms in Parkinson's disease patients

Constant infusion of a drug now used intermittently to "rescue" patients with Parkinson's from bouts of immobility may also help avoid these debilitating symptoms and smooth out their movement throughout the day, physician-scientists say.

14 Feb 2017

Children born of fathers exposed to nicotine inherit enhanced chemical tolerance, study shows

A father's nicotine use may have a significant impact on children's risk of some diseases. In a study published in the online biomedical sciences journal eLife, Oliver J. Rando, MD, PhD, and colleagues at UMass Medical School, demonstrate that mice born of fathers who are habitually exposed to nicotine inherit enhanced chemical tolerance and drug clearance abilities.

14 Feb 2017

New RNAi treatment safely blocks ocular inflammation in mice

Scientists have developed a new RNA interference therapeutic agent that safely blocked ocular inflammation in mice, potentially making it a new treatment for human uveitis and diabetic retinopathy.

14 Feb 2017

Receptor News and Research

Precise inactivation of neurotransmitter receptors using CALI technique erases fear memory in mice

Study shows how variations in receptor genes may lead to obsessive-compulsive disorder traits

Study finds biochemical pathway that triggers regrowth of breast cancer stem cells after chemotherapy

UAB researchers developing new peptide that may help combat familial hypercholesterolemia

Gene expression patterns could help predict treatment for breast cancer, research shows

Compound from snail's venom may offer alternative to opioids for pain relief

EPFL scientists develop new computer model for better design of allosteric drugs

Penn researchers find new way to track rare T cells in blood after annual flu vaccine

SLU scientist examines potential biomarkers for pain linked to debilitating health conditions

Study identifies protein in tumor microenvironment that promotes breast cancer spread

New research provides clues to how antibody treatment led to remission in SIV-infected monkeys

Mice study shows how WAVE1 protein regulates the brain's response to cocaine

Two-drug combination shows promise against diabetic retinopathy in animal models

Researchers pinpoint new neural mechanism that regulates chronic stress response

Only subset of mother's HIV virus infects infants during pregnancy or breastfeeding, research shows

Research opens treatment pathways for cancers that do not respond to targeted antibodies

Researchers explore role played by nicotine in grouping of nicotinic receptors within the brain

New infusion therapy may help avoid debilitating symptoms in Parkinson's disease patients

Children born of fathers exposed to nicotine inherit enhanced chemical tolerance, study shows

New RNAi treatment safely blocks ocular inflammation in mice

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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