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Raising dopamine levels in frontal cortex reduces impulsivity in healthy adults

Raising levels of the neurotransmitter dopamine in the frontal cortex of the brain significantly decreased impulsivity in healthy adults, in a study conducted by researchers at the Ernest Gallo Clinic and Research Center at the University of California, San Francisco.

26 Jul 2012

Molecular explanation for increased susceptibility to intestinal inflammation in malnutrition

More than one billion people in poor countries are starving, and malnutrition remains a major problem even in rich countries, making it a leading cause of death in the world. For over a hundred years, doctors have known that a lack of protein in the diet or low levels of amino acids, the building blocks of proteins, can lead to symptoms like diarrhoea, inflamed intestines and other immune system disorders, which weaken the body and can be fatal. However, the molecular mechanism which explains how malnutrition causes such severe symptoms has been largely unexplored.

26 Jul 2012

Single event of brain trauma can lead to Alzheimer’s

A study, performed in mice and utilizing post-mortem samples of brains from patients with Alzheimer’s disease, found that a single event of a moderate-to-severe traumatic brain injury (TBI) can disrupt proteins that regulate an enzyme associated with Alzheimer’s. The paper, published in The Journal of Neuroscience, identifies the complex mechanisms that result in a rapid and robust post-injury elevation of the enzyme, BACE1, in the brain. These results may lead to the development of a drug treatment that targets this mechanism to slow the progression of Alzheimer’s disease.

25 Jul 2012

New tool uses fluorescence to distinguish cancerous tissue from normal one in low-grade tumors

A new probe developed collaboratively at Norris Cotton Cancer Center and Dartmouth College's Thayer School of Engineering uses an innovative fluorescence-reading technology to help brain surgeons distinguish cancerous tissue from normal tissue. The probe tool, now already in use at the Cancer Center for brain surgery, may one day be used for surgeries for a variety of cancers.

25 Jul 2012

Moderate-to-severe TBI can disrupt proteins that regulate enzyme associated with Alzheimer's

A study, performed in mice and utilizing post-mortem samples of brains from patients with Alzheimer's disease, found that a single event of a moderate-to-severe traumatic brain injury (TBI) can disrupt proteins that regulate an enzyme associated with Alzheimer's.

25 Jul 2012

New FDA guidelines on HIV And TB drug doses may not apply to African and Asian patients

In January, 2012, the U.S. Food and Drug Administration (FDA) issued new guidelines on dosing of an HIV medication used to treat people infected with both HIV and tuberculosis (TB) because of a potential interaction between two of the main drugs used to treat each disease.

24 Jul 2012

Scientists identify mechanisms by which GLP-1 protects against kidney disease, diabetes

Scientists at Joslin Diabetes Center have identified biological mechanisms by which glucagon-like peptide-1 (GLP-1), a gut hormone, protects against kidney disease, and also mechanisms that inhibit its actions in diabetes.

24 Jul 2012

Scientists demonstrate link between cancer and faulty differentiation of stem cells

Stem cells hold great promise for the medicine of the future, but they can also be a cause of disease. When these self-renewing, unspecialized cells fail to differentiate into diverse cell types, they can start dividing uncontrollably, leading to cancer. Already several decades ago, Weizmann Institute scientists were among the first to demonstrate the link between cancer and the faulty differentiation of stem cells. Now a new Weizmann Institute-led study, published in Molecular Cell, reveals a potential molecular mechanism behind this link.

24 Jul 2012

Genetic underpinnings of Wiedemann-Steiner syndrome identified

Researchers have identified a genetic underpinning of Wiedemann-Steiner syndrome.

23 Jul 2012

Linagliptin safe and effective for long-term management of type 2 diabetes

An extended trial of a drug for people with type 2 diabetes has confirmed that the oral DPP-4 inhibitor linagliptin is a safe and effective means of lowering glucose levels for up to 102 weeks, either on its own or in combination with other selected oral anti-diabetic medication.

23 Jul 2012

Researchers uncover protein structure that regulates blood cell formation and activity

A Finnish research team together with researchers from New York, USA, has uncovered a protein structure that regulates cell signalling and the formation of blood cells. The team's results, published in Nature Structural & Molecular Biology, the most prestigious journal in the field, shed light on the mechanisms at play in haematological disorders and provide new opportunities for the design of disease-specific treatment.

23 Jul 2012

Yeast gene can increase ethanol production yield by up to 34%

iDiverse announced that it has discovered a yeast gene that when inserted into yeast and properly modulated can increase ethanol production yield by up to 34%.

23 Jul 2012

Regeneron, Sanofi initiate enrollment in SAR236553/REGN727 Phase 3 program

Sanofi and Regeneron Pharmaceuticals, Inc. announced today that several trials within ODYSSEY, the Phase 3 clinical program of SAR236553/REGN727, have initiated patient enrollment.

21 Jul 2012

Unexplained fatigue in women: start iron supplements

Iron deficiency may be underdiagnosed in women of child-bearing age who report considerable fatigue, say researchers whose randomized controlled trial results show a significant reduction in fatigue after women took iron supplements.

20 Jul 2012

Silymarin does not offer significant improvements for patients with HCV

Silymarin, an extract of milk thistle commonly used to treat chronic liver disease by millions of people around the World, does not offer significant improvements for patients, according to a new study conducted by a nationwide group of researchers including faculty at the Perelman School of Medicine at the University of Pennsylvania.

20 Jul 2012

Scientists identify inhibitors of key enzyme involved in survival of malaria parasite

An international team of scientists, led by researchers from the Department of Pediatrics at the University of California, San Diego School of Medicine, have identified the first reported inhibitors of a key enzyme involved in survival of the parasite responsible for malaria. Their findings, which may provide the basis for anti-malarial drug development, are currently published in the online version of the Journal of Medicinal Chemistry.

20 Jul 2012

Conatus, University of Alberta initiate islet cell transplant Phase I/II trial of emricasan for diabetes

Conatus Pharmaceuticals Inc. and the University of Alberta announced today the treatment of the first patient in an investigator-initiated islet cell transplant Phase I/II trial of emricasan (IDN-6556), a pan-caspase inhibitor.

20 Jul 2012

Bryologs more potent than prostratin in treating HIV

Thanks to antiretrovirals, an AIDS diagnosis hasn't been a death sentence for nearly two decades. But highly active antiretroviral therapy, or HAART, is also not a cure.

19 Jul 2012

Silymarin does not provide greater benefit for patients with chronic HCV infection

Use of the botanical product silymarin, an extract of milk thistle that is commonly used by some patients with chronic liver disease, did not provide greater benefit than placebo for patients with treatment-resistant chronic hepatitis C virus (HCV) infection, according to a study in the July 18 issue of JAMA.

18 Jul 2012

Researchers uncover mechanism by which aging may weaken immune response

Researchers at Albert Einstein College of Medicine of Yeshiva University have uncovered one of the mechanisms by which aging may compromise the ability of the immune system to fight infections and respond to vaccines.

18 Jul 2012

Enzyme News and Research

Raising dopamine levels in frontal cortex reduces impulsivity in healthy adults

Molecular explanation for increased susceptibility to intestinal inflammation in malnutrition

Single event of brain trauma can lead to Alzheimer’s

New tool uses fluorescence to distinguish cancerous tissue from normal one in low-grade tumors

Moderate-to-severe TBI can disrupt proteins that regulate enzyme associated with Alzheimer's

New FDA guidelines on HIV And TB drug doses may not apply to African and Asian patients

Scientists identify mechanisms by which GLP-1 protects against kidney disease, diabetes

Scientists demonstrate link between cancer and faulty differentiation of stem cells

Genetic underpinnings of Wiedemann-Steiner syndrome identified

Linagliptin safe and effective for long-term management of type 2 diabetes

Researchers uncover protein structure that regulates blood cell formation and activity

Yeast gene can increase ethanol production yield by up to 34%

Regeneron, Sanofi initiate enrollment in SAR236553/REGN727 Phase 3 program

Unexplained fatigue in women: start iron supplements

Silymarin does not offer significant improvements for patients with HCV

Scientists identify inhibitors of key enzyme involved in survival of malaria parasite

Conatus, University of Alberta initiate islet cell transplant Phase I/II trial of emricasan for diabetes

Bryologs more potent than prostratin in treating HIV

Silymarin does not provide greater benefit for patients with chronic HCV infection

Researchers uncover mechanism by which aging may weaken immune response

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

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