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Positive results from PLX4032 Phase 3 Trial in patients with metastatic melanoma

Plexxikon today announced positive data from an interim analysis of the BRIM3 trial, a large multi-center Phase 3 clinical study of PLX4032 in patients with previously untreated metastatic melanoma with the BRAF mutation. Patients treated with PLX4032 had an improved overall survival compared to patients treated with dacarbazine, the current standard of care.

19 Jan 2011

PAM50 test is now available to classify breast cancer subtypes

ARUP Laboratories, a leading national clinical and anatomic pathology reference laboratory and a leader in innovative laboratory research and development, today announced the availability of a new laboratory developed test designed to classify breast cancer into clinically significant molecular subtypes that are important for the management of the disease.

18 Jan 2011

Heart disease patients' skin cells may help test long QT syndrome

Skin cells from a patient with an inherited heart disease were the seeds of a stem cell experiment that could help researchers test specific treatments for the disease, known as long QT syndrome. The research results appear in the January 16 issue of the journal Nature.

18 Jan 2011

Scientists create GM chicken that does not spread bird flu to other chickens

"Scientists have developed genetically modified [GM] chickens that don't transmit bird flu [H5N1] to other chickens," HealthDay News/Bloomberg Businessweek reports.

18 Jan 2011

Clinical studies by expert HIV clinicians suggest that HIV-TRePS may have clinical and economic benefits

Two multinational clinical studies indicate that the RDI’s system for predicting how HIV and AIDS patients will respond to different drugs could be a useful tool with potential clinical and economic benefits. The studies, published in the January issue of AIDS Patient Care and STDs, involved highly experienced physicians in the USA, Canada and Italy who used the system to help them select the optimum combination of HIV drugs for patients whose therapy was failing.

18 Jan 2011

New study reveals measles viral gene plays key role in development of PD

A gene from the measles virus plays a key role in the development of Paget's disease of bone, according to a team of researchers led by the University of Pittsburgh School of Medicine.

18 Jan 2011

'Pacemaker' Hcn4 gene responsible for generation of repetitive activity in SAN tissue and heart rate regulation

The study of Dario DiFrancesco and his equipe identifies the "pacemaker" Hcn4 gene as the gene functionally responsible for the generation of repetitive activity in sinoatrial node tissue and for the regulation of heart rate. Hcn4 codes for HCN4 channels, the molecular components of "funny" ion channels of pacemaker cells of the sinoatrial node (SAN) tissue.

14 Jan 2011

Researchers discover molecular mechanism behind coffee's protective effect

Coffee, that morning elixir, may give us an early jump-start to the day, but numerous studies have shown that it also may be protective against type 2 diabetes. Yet no one has really understood why.

14 Jan 2011

Scientists demonstrate how one gene evolves two competing functions via duplication

Researchers report that they are the first to show in molecular detail how one gene evolved two competing functions that eventually split up - via gene duplication - to pursue their separate destinies.

13 Jan 2011

BIDMC scientist wins 2011 Pezcoller Foundation-AACR International Award for cancer research

Beth Israel Deaconess Medical Center cancer geneticist Pier Paolo Pandolfi, MD, PhD, is the recipient of the 2011 Pezcoller Foundation-AACR (American Association of Cancer Research) International Award for Cancer Research.

13 Jan 2011

New discovery has brought dream of transforming measles virus against cancer

When most people in the developed world think of measles, what comes to mind is only a dim memory of a vaccination at a pediatrician's office. But while childhood vaccination has virtually eliminated measles from North America and much of Europe, researchers remain interested in the virus.

13 Jan 2011

Scientists find way to prevent early stage pancreatic cancer in research models

Cancer researchers at The Peggy and Charles Stephenson Oklahoma Cancer Center have found a way to stop early stage pancreatic cancer in research models - a result that has far-reaching implications in chemoprevention for high-risk patients.

12 Jan 2011

Antibodies produced by people who recovered from H1N1 offer clues for universal flu vaccine

The antibodies produced by individuals who fought off H1N1 (swine flu) infection last year may bring researchers one step closer to their quest to develop a "universal" flu vaccine, U.S. researchers said Monday, HealthDay News/Bloomberg Businessweek reports.

12 Jan 2011

Novel scoring system identifies PTEN genetic mutation

Researchers have discovered a method for more precise identification of individuals who should undergo testing for genetic mutations of the tumor suppressor gene PTEN, which associates with a variety of conditions including several types of cancers. The research has created a diagnostic scoring system that improves on established criteria.

11 Jan 2011

QIAGEN to acquire minority stake in Alacris Theranostics

QIAGEN has signed an agreement for the acquisition of a strategic stake in Alacris Theranostics GmbH, a German start-up company using novel technologies to develop individualized cancer treatment strategies based upon a patient's genomic profile, and for the acquisition of an exclusive option to access all biomarkers emerging from this discovery program.

From QIAGEN Manchester Limited 11 Jan 2011

Oncolytics opens enrollment in REOLYSIN combination U.S. Phase I colorectal cancer study

Oncolytics Biotech Inc. announced today that a U.S. Phase I study of REOLYSIN® in combination with FOLFIRI (Folinic Acid (leucovorin) + Fluorouracil (5-FU) + Irinotecan) in patients with oxaliplatin refractory/intolerant Kras mutant colorectal cancer (REO 022) is now open to enrollment. The principal investigator is Dr. Sanjay Goel of the Montefiore Medical Center at The Albert Einstein College of Medicine in New York.

10 Jan 2011

Researchers demystify death of brain cells in Parkinson's patients

Just 5 percent of Parkinson's disease cases can be explained by genetic mutation, while the rest have no known cause. But a new discovery by researchers at The University of Texas Health Science Center San Antonio may begin to explain why the vast majority of Parkinson's patients develop the progressive neurodegenerative disease.

10 Jan 2011

Researchers identify gene mutation for that is essential for correct protein-processing in cells

A Jackson Laboratory research team led by Professor Patsy Nishina, Ph.D., has identified a mutation in a gene that's essential for correct protein-processing in cells. Defects in protein folding are associated with a variety of abnormalities and diseases.

10 Jan 2011

AFQ056 drug improves symptoms in Fragile X patients: Study

The first drug to treat the underlying disorder instead of the symptoms of Fragile X, the most common cause of inherited intellectual disability, shows some promise according to a new study published in the January issue of Science Translational Medicine.

9 Jan 2011

Gigantism gene inherited by hundreds: Study

A gene that predicted gigantism in humans was identified in the DNA of the 18th-century man known as the Irish Giant, who was more than 7 feet 7 inches tall. Copies of the same mutation have been found in patients today who suffer from excessive growth, and scientists have concluded they all inherited the gene from a common ancestor.

9 Jan 2011

Mutation News and Research

Positive results from PLX4032 Phase 3 Trial in patients with metastatic melanoma

PAM50 test is now available to classify breast cancer subtypes

Heart disease patients' skin cells may help test long QT syndrome

Scientists create GM chicken that does not spread bird flu to other chickens

Clinical studies by expert HIV clinicians suggest that HIV-TRePS may have clinical and economic benefits

New study reveals measles viral gene plays key role in development of PD

'Pacemaker' Hcn4 gene responsible for generation of repetitive activity in SAN tissue and heart rate regulation

Researchers discover molecular mechanism behind coffee's protective effect

Scientists demonstrate how one gene evolves two competing functions via duplication

BIDMC scientist wins 2011 Pezcoller Foundation-AACR International Award for cancer research

New discovery has brought dream of transforming measles virus against cancer

Scientists find way to prevent early stage pancreatic cancer in research models

Antibodies produced by people who recovered from H1N1 offer clues for universal flu vaccine

Novel scoring system identifies PTEN genetic mutation

QIAGEN to acquire minority stake in Alacris Theranostics

Oncolytics opens enrollment in REOLYSIN combination U.S. Phase I colorectal cancer study

Researchers demystify death of brain cells in Parkinson's patients

Researchers identify gene mutation for that is essential for correct protein-processing in cells

AFQ056 drug improves symptoms in Fragile X patients: Study

Gigantism gene inherited by hundreds: Study

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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