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Study suggests new anti-KRAS drug as a strong candidate for pancreatic cancer clinical trials

A small molecule inhibitor that attacks the difficult to target, cancer-causing gene mutation KRAS, found in nearly 30 percent of all human tumors, successfully shrunk tumors or stopped cancer growth in preclinical models of pancreatic cancer, researchers from Penn Medicine's Abramson Cancer Center showed, suggesting the drug is a strong candidate for clinical trials.

6 Dec 2022

Research explores how alignment of endothelial cells plays a role in cancer metastasis

Preventing metastasis – the development of cancer cells beyond their original location – remains one of the major goals of current cancer research.

6 Dec 2022

Consistent exercise linked to beneficial epigenetic changes, twin-study shows

Consistent exercise can change not just waistlines but the very molecules in the human body that influence how genes behave, a new study of twins indicates.

6 Dec 2022

Research reveals a novel viral strategy in modulating stress granule formation to promote virus infection

Researchers illustrated a novel strategy likely employed by viruses to promote infection.

6 Dec 2022

The critical role of flow cytometry in CAR+ T-Cell trials

In this interview, Ryan Muise talks to AZoNetwork about the added value of using flow cytometry in CAR T-Cell clinical trials.

From Cerba Research 6 Dec 2022

Pre-Plated Assay Solutions That Can Help Accelerate Biotech

In this interview, we speak with University of Warwick spin-out Cryologyx about their innovative new technology that hopes to revolutionize cell-based assays for researchers across life sciences and drug discovery.

From Cryologyx Ltd 6 Dec 2022

NUS scientists develop novel low-cost method of testing for cancers

Scientists from the National University of have discovered a novel low-cost method of testing for cancers.

5 Dec 2022

Study explores histopathological, serological, and clinical characteristics of PASC in patients with mild COVID-19

Researchers investigated the clinical, histopathological, imaging, and serological characteristics of post-acute sequelae of coronavirus disease 2019 (COVID-19) (PASC) in patients with mild COVID-19.

5 Dec 2022

Immunopeptidome characters of human CoV-OC43-infected cells

Researchers explored T-cell epitopes derived from human seasonal coronavirus OC43.

5 Dec 2022

Study explores practical pathways to motherhood in women with oncogene-driven lung cancer

New research from the University of Colorado (CU) Cancer Center highlights the need for additional data collection for women hoping to have successful pregnancies while undergoing treatment for lung cancer.

5 Dec 2022

Study predicts persistent cross-species SARS-CoV-2 variant infectivity

Scientists believe bats first transmitted SARS-CoV-2 to humans in December 2019, and while the virus has since evolved into several variants such as delta and omicron, a new study indicates the virus is still highly transmissible between mammals.

5 Dec 2022

New insights into how the circadian clock influences T cell responses to vaccination

Research by RCSI University of Medicine and Health Sciences has provided new insights into the mechanism behind how our circadian 24-hour body clock influences our immune response to vaccines, depending on the time of day.

5 Dec 2022

Discovery offers an avenue for development of novel therapies for Chagas disease

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects some 8 million people worldwide. More than a third develop severe heart or digestive problems with a heightened risk of death.

5 Dec 2022

Natural material derived from seaweed can help improve outcomes after heart bypass surgery

Researchers are using a natural material derived from seaweed to promote vascular cell growth, prevent blood clots and improve the performance of synthetic vascular grafts used in heart bypass surgery.

5 Dec 2022

Study provides understanding of SARS-CoV-2 pulmonary infection long-term effects at the microanatomical, cellular, and molecular level

Researchers evaluated compositional and structural pulmonary alterations in PASC tissues.

5 Dec 2022

Comparison of blood plasma protein expression in mild, moderate, and severe COVID-19 identifies novel disease severity biomarkers

Researchers evaluated blood plasma proteins to identify new targets for COVID-19 treatment approaches and prevent complications associated with severe illness.

5 Dec 2022

Researchers develop a polyvalent lipid nanoparticle mRNA vaccine against Monkeypox virus

Researchers developed an mRNA technology-based vaccine candidate against the monkeypox virus and evaluated its immunogenicity in animal models.

5 Dec 2022

Researchers uncover the host protease CAPN2 as a novel host factor that aids the infection of SARS-CoV-2

Researchers investigated the potential of the CAPN2 molecule as a therapeutic target against SARS-CoV-2.

5 Dec 2022

How two structurally different lemon pectins modulate the gut microbiota

A diet containing fruits and vegetables contains pectins (plant polysaccharides). Pectin cannot be metabolized by mammalian cells in the gastrointestinal tract but is fermented by the gut microbiota in the colon, where short-chain fatty acids (SCFAs) are released. Previous studies have examined pectin's prebiotic properties.

4 Dec 2022

Trial shows acoziborole drug clears body of African sleeping sickness parasites

Researchers evaluate the efficacy and safety of an oral antimicrobial drug acoziborole in patients with human African trypanosomiasis.

4 Dec 2022

B Cell News and Research

Study suggests new anti-KRAS drug as a strong candidate for pancreatic cancer clinical trials

Research explores how alignment of endothelial cells plays a role in cancer metastasis

Consistent exercise linked to beneficial epigenetic changes, twin-study shows

Research reveals a novel viral strategy in modulating stress granule formation to promote virus infection

The critical role of flow cytometry in CAR+ T-Cell trials

Pre-Plated Assay Solutions That Can Help Accelerate Biotech

NUS scientists develop novel low-cost method of testing for cancers

Study explores histopathological, serological, and clinical characteristics of PASC in patients with mild COVID-19

Immunopeptidome characters of human CoV-OC43-infected cells

Study explores practical pathways to motherhood in women with oncogene-driven lung cancer

Study predicts persistent cross-species SARS-CoV-2 variant infectivity

New insights into how the circadian clock influences T cell responses to vaccination

Discovery offers an avenue for development of novel therapies for Chagas disease

Natural material derived from seaweed can help improve outcomes after heart bypass surgery

Study provides understanding of SARS-CoV-2 pulmonary infection long-term effects at the microanatomical, cellular, and molecular level

Comparison of blood plasma protein expression in mild, moderate, and severe COVID-19 identifies novel disease severity biomarkers

Researchers develop a polyvalent lipid nanoparticle mRNA vaccine against Monkeypox virus

Researchers uncover the host protease CAPN2 as a novel host factor that aids the infection of SARS-CoV-2

How two structurally different lemon pectins modulate the gut microbiota

Trial shows acoziborole drug clears body of African sleeping sickness parasites

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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