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The genetics of neurogenic inflammation in rosacea

Researchers identify rare genetic variants in families with rosacea.

11 Jul 2023

FKBP5 deficiency linked to atrial fibrillation

Atrial fibrillation (AFib) is the most common type of heart arrhythmia. This serious condition occurs when the heart beats so fast that the upper chambers of the heart quiver.

6 Jul 2023

New therapy to mitigate fragile X syndrome may be on the horizon

An antisense therapy developed by Joel D. Richter, PhD, Sneha Shah, PhD, and Jonathan K. Watts, PhD, at UMass Chan Medical School and Elizabeth Berry-Kravis, MD, PhD, at RUSH University Medical Center, restores production of the protein FMRP in cell samples taken from patients with fragile X syndrome.

5 Jul 2023

Researchers uncover the role of glutaminase 2 in glucose homeostasis

Glutaminase 2 (GLS2) is a master regulator of glutaminolysis. GLS2 converts glutamine to glutamate, thereby playing a role in cellular energy production. GLS2 is abundant in the liver, and is also found in pancreatic β-cells. However, the role of GLS2 in pancreatic islets – in which both ɑ- and β- cells are present – associated with glucose metabolism is currently unknown.

5 Jul 2023

Resistance training could be a simple and affordable therapy for Alzheimer's patients

Regular physical exercise, such as resistance training, can prevent Alzheimer's disease, or at least delay the appearance of symptoms, and serves as a simple and affordable therapy for Alzheimer's patients.

3 Jul 2023

Ancient retrovirus may be responsible for aggressive brain cancers

The median length of survival after diagnosis of glioblastoma is 14 months, but some of these brain tumors are more aggressive and resistant to treatment than others, and a new study from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine suggests reactivation of an ancient retrovirus may be at least partly to blame.

3 Jul 2023

Cell therapy using genome-edited iPS cells could be a new treatment for Fabry disease

Induced pluripotent stem (iPS) cells have a great impact on biology and medicine, and they are expected to improve regenerative medicine.

3 Jul 2023

Spanish researchers develop new immunotherapy combination for liver cancer

Spanish researchers at Cima University of Navarra have developed a new immunotherapy combination that improves efficacy in animal models of hepatocellular carcinoma. This is a proof of concept that lays the foundations for the application of this treatment in patients with the most common liver cancer.

1 Jul 2023

Novel drug combination shows promise in treating pancreatic cancer

Mutations in the KRAS gene are the major driver of pancreatic cancer. The resulting protein controls multiple signaling pathways involved in cell growth and survival. In cancer, the gene is mutated to be permanently "on," driving cells to excessively multiply and form tumors.

28 Jun 2023

GREB1 gene key to liver cancer development, study finds

The development of hepatocellular carcinoma, liver cancer, is known to involve abnormal activation of a signaling pathway called Wnt; however, the underlying mechanisms have not been fully understood, until now.

27 Jun 2023

Study reveals neural circuits underlying adolescent stress-induced postpartum social behavior

Stress during adolescence can cause postpartum behavioral changes in women and other mammals, including depression and changes in social behavior after the birth of a child.

23 Jun 2023

Scientists uncover molecular mechanism contributing to defective heart development in Down syndrome

Infants born with Down syndrome, the genetic condition caused by an extra copy of chromosome 21, or trisomy 21, are highly predisposed to congenital heart defects.

21 Jun 2023

Research explains mechanisms behind anti-viral protection in hemochorial placentas

Give credit to your dad's gene for keeping you safe during those long months in your mother's womb.

20 Jun 2023

Oral probiotic bacterial strain found to improve dry eye disease in animal model

In a study by a research group at Baylor College of Medicine, oral administration of a commercially available probiotic bacterial strain was found to improve dry eye disease in an animal model.

18 Jun 2023

Does taurine deficiency speed up aging?

The association of the amino acid taurine with aging.

16 Jun 2023

Determining the effect of estriol treatment on cerebral cortex in the preclinical model of MS

Treating a mouse model of multiple sclerosis with the pregnancy hormone estriol reversed the breakdown of myelin in the brain's cortex, a key region affected in multiple sclerosis, according to a new UCLA Health study.

16 Jun 2023

Moderate exercise can influence the inflammatory responses of macrophages, research shows

Researchers have long known that moderate exercise has a beneficial impact on the body's response to inflammation, but what's been less understood is why.

15 Jun 2023

Detailed 3D images of the synapse offer precise geometry of interactions between individual cells

Scientists have created one of the most detailed 3D images of the synapse, the important juncture where neurons communicate with each other through an exchange of chemical signals. These nanometer scale models will help scientists better understand and study neurodegenerative diseases such as Huntington's disease and schizophrenia.

15 Jun 2023

Exploring how Bourbon virus-carrying ticks travel through wildlife and to people

On a cold spring morning, Washington University in St. Louis virologist Jacco Boon, PhD, and wildlife ecologist Solny Adalsteinsson, PhD, flap and drag a large white flag through a woodsy area on the western edge of St. Louis County. Boon, an associate professor of medicine in infectious diseases at Washington University School of Medicine in St. Louis, and Adalsteinsson, a senior scientist at the university's Tyson Research Center, are looking for lone star ticks that carry the potentially deadly Bourbon virus.

14 Jun 2023

Transgenic mouse model reveals surprising new connections between peripheral nerves and the heart

Oxidative stress – characterized by elevated levels of unstable molecules called reactive oxygen species– is associated with neurodegeneration and cardiovascular disease.

14 Jun 2023

Mouse Model News and Research

The genetics of neurogenic inflammation in rosacea

FKBP5 deficiency linked to atrial fibrillation

New therapy to mitigate fragile X syndrome may be on the horizon

Researchers uncover the role of glutaminase 2 in glucose homeostasis

Resistance training could be a simple and affordable therapy for Alzheimer's patients

Ancient retrovirus may be responsible for aggressive brain cancers

Cell therapy using genome-edited iPS cells could be a new treatment for Fabry disease

Spanish researchers develop new immunotherapy combination for liver cancer

Novel drug combination shows promise in treating pancreatic cancer

GREB1 gene key to liver cancer development, study finds

Study reveals neural circuits underlying adolescent stress-induced postpartum social behavior

Scientists uncover molecular mechanism contributing to defective heart development in Down syndrome

Research explains mechanisms behind anti-viral protection in hemochorial placentas

Oral probiotic bacterial strain found to improve dry eye disease in animal model

Does taurine deficiency speed up aging?

Determining the effect of estriol treatment on cerebral cortex in the preclinical model of MS

Moderate exercise can influence the inflammatory responses of macrophages, research shows

Detailed 3D images of the synapse offer precise geometry of interactions between individual cells

Exploring how Bourbon virus-carrying ticks travel through wildlife and to people

Transgenic mouse model reveals surprising new connections between peripheral nerves and the heart

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