Protein C News and Research

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Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

A new paper in the journal Molecules describes this in molecular terms, comparing SARS-CoV-2 with an earlier highly pathogenic coronavirus, SARS-CoV.

31 Jan 2022

A substrate envelope approach to examine drug resistance potential of SARS-CoV-2 Mpro

A team of scientists from the United States has recently defined the substrate envelop of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The study is currently available on the bioRxiv* preprint server while awaiting peer review.

31 Jan 2022

Vaccine-induced immunological memory is similar for Omicron and Delta SARS-CoV-2 variants

A new study by Norwegian researchers suggests that vaccine-induced immunological memory and the activation of recall responses in the body yields similar coverage for Omicron and Delta variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The paper is currently available on the medRxiv* preprint server while it undergoes peer review.

31 Jan 2022

Research shows minks mimic severe COVID-19 symptoms, including ARDS

Minks may be a suitable animal model for testing severe COVID-19 infections, finds a recent bioRxiv* preprint study. While mice and ferrets are used in preclinical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is currently no model specific to severe disease.

30 Jan 2022

Study shows homologous COVID boosters better than heterologous in most kidney transplant recipients

Researchers screen kidney transplant recipients to evaluate their serological responses following immunization with three doses of the COVID-19 vaccine.

30 Jan 2022

Immunity based upon “mild" Omicron infection is weak for Omicron reinfection

Researchers evaluate antibody responses in vaccinated individuals who subsequently developed Delta and Omicron SARS-CoV-2 breakthrough infections.

30 Jan 2022

COVID-19 vaccines elicit cross-reactive antibodies against endemic coronaviruses

Researchers study the interaction between immunity to endemic coronaviruses and SARS-CoV-2.

30 Jan 2022

Scientists evaluate zoonotic potential of NeoCoV, a coronavirus related to MERS-CoV

Researchers identify ACE2 as the functional receptor of the two close relatives of MERS-CoV, NeoCoV and PDF-2180-CoV, in bats.

30 Jan 2022

Using lateral flow testing to define COVID-19 self-isolation period

A recent study discusses the role of lateral flow device testing in potentially improving COVID-19 isolation policies.

30 Jan 2022

Imaging microscopy shows killer T-cells targeting SARS-CoV-2 spike protein

Researchers demonstrate how cytotoxic T-lymphocytes (CTLs) with specificity for SARS-CoV-2 eliminate multiple infected targets.

30 Jan 2022

Adults and children have similar neutralizing antibody responses to SARS-CoV-2 infection

Researchers describe the kinetics of SARS-CoV-2-specific serum antibodies in convalescent children over six months following infection.

30 Jan 2022

Study reveals link between muscular dystrophy and sphingolipids

In a new study, the group of Johan Auwerx at EPFL's School of Life Sciences has made the first connection between muscular dystrophy and sphingolipids, a group of bioactive lipids. The study is published in Science Advances.

29 Jan 2022

Intranasal vaccine with nanoparticles offers strong protection against influenza viruses

An influenza vaccine administered through the nose and constructed with nanoparticles that enhance immune response offers strong protection against different influenza virus strains, according to researchers in the Institute for Biomedical Sciences at Georgia State University.

29 Jan 2022

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

The Damon Runyon Cancer Research Foundation has announced its newest cohort of Damon Runyon Fellows, 13 outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

29 Jan 2022

Researchers receive £4.9 million to investigate pioneering biological electronics

Researchers from universities across the UK, led by the University of Bristol, have been awarded £4.9 million from the Biotechnology and Biological Sciences Research Council (BBSRC), the UK's largest bioscience funder, to investigate how electrons and energy flow through biological molecules by building artificial protein-based wires and circuits.

29 Jan 2022

Study provides atomistic level insight into target residence time of small molecule kinase inhibitors

When a drug molecule binds to its target protein, it stays bound for some time before eventually unbinding the target. The actual time how long a drug molecule resides bound to its target varies among compounds.

29 Jan 2022

Study reveals role of a protein in healthy functioning of blood stem cells

A protein that masterminds the way DNA is wrapped within chromosomes has a major role in the healthy functioning of blood stem cells, which produce all blood cells in the body, according to a new study from researchers at Weill Cornell Medicine.

28 Jan 2022

Hospitalized COVID-19 patients more likely to experience heavy bleeding when prescribed full-dose blood thinners

Patients with COVID-19 in the intensive care unit (ICU) prescribed full-dose blood thinners are significantly more likely to experience heavy bleeding than patients prescribed a smaller yet equally effective dose, according to a recent University at Buffalo-led study.

28 Jan 2022

Mix-and-match of COVID-19 vaccine boosters found to be safe and effective

In adults who had previously received a full regimen of a COVID-19 vaccine approved or authorized by the Food and Drug Administration (FDA), an additional dose of any of these COVID-19 vaccines was safe and prompted an immune response, according to study findings published Jan. 26 in The New England Journal of Medicine.

28 Jan 2022

Novel “prime and spike” vaccine strategy leverages existing immunity generated by primary COVID-19 vaccination

Scientists from Yale University, USA, have recently developed an intranasal spike boosting vaccine that induces robust mucosal immunity in the respiratory tract,

28 Jan 2022

Protein C News and Research

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

A substrate envelope approach to examine drug resistance potential of SARS-CoV-2 Mpro

Vaccine-induced immunological memory is similar for Omicron and Delta SARS-CoV-2 variants

Research shows minks mimic severe COVID-19 symptoms, including ARDS

Study shows homologous COVID boosters better than heterologous in most kidney transplant recipients

Immunity based upon “mild" Omicron infection is weak for Omicron reinfection

COVID-19 vaccines elicit cross-reactive antibodies against endemic coronaviruses

Scientists evaluate zoonotic potential of NeoCoV, a coronavirus related to MERS-CoV

Using lateral flow testing to define COVID-19 self-isolation period

Imaging microscopy shows killer T-cells targeting SARS-CoV-2 spike protein

Adults and children have similar neutralizing antibody responses to SARS-CoV-2 infection

Study reveals link between muscular dystrophy and sphingolipids

Intranasal vaccine with nanoparticles offers strong protection against influenza viruses

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

Researchers receive £4.9 million to investigate pioneering biological electronics

Study provides atomistic level insight into target residence time of small molecule kinase inhibitors

Study reveals role of a protein in healthy functioning of blood stem cells

Hospitalized COVID-19 patients more likely to experience heavy bleeding when prescribed full-dose blood thinners

Mix-and-match of COVID-19 vaccine boosters found to be safe and effective

Novel “prime and spike” vaccine strategy leverages existing immunity generated by primary COVID-19 vaccination

Industry Focus eBook - Cell biology (5th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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