Protein C News and Research

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A synthesis of evidence sheds light on major immune components and mechanisms involved in COVID-19

New research highlights principal host factors that may explain the immune responses to SARS-CoV-2 and its variants in the context of infection susceptibility, disease severity, and previous immunity.

28 Jan 2022

Reduced neutralization against Omicron variant in fully immunized adolescents with BNT162b2 vaccine

Researchers compare the humoral immune response in adolescents and adults after being completely immunized with the Pfizer BNT162b2 vaccine.

28 Jan 2022

γ’ fibrinogen as a disease progression marker for COVID-19

Levels of the inflammatory biomarker gamma prime fibrinogen (γ' Fbg) varies according to severity in COVID-19 patients.

28 Jan 2022

Impact of DNA clearance on mortality in patients with severe COVID-19 infections

In a new study, researchers conducted activity-based proteomic profiling of patients who had severe SARS-CoV-2 infections to understand the impact of DNA clearance on mortality.

28 Jan 2022

Potential therapy candidates for patients infected with the SARS-CoV-2 Omicron variant

Researcher discusses several promising therapeutic candidates that have been proposed for the treatment of patients infected with the Omicron variant.

28 Jan 2022

Study demonstrates minimally invasive, aerosolized vaccine candidate to combat SARS-CoV-2

This study showed inhalable Covid-19 mimetic particle carriers as potential, versatile, aerosolizable COVID-19 vaccine candidates if worked on with continued optimization and refinement.

28 Jan 2022

Magnetic nanoparticles for SARS-CoV-2 and other virus detection systems

Researchers discuss the contributions that have been provided by magnetic nanoparticles for the molecular diagnosis of human viruses.

28 Jan 2022

Exploring receptor-blocking conserved non-neutralizing antibodies for SARS-CoV-2 therapy

In a new study, researchers hypothesized and developed broad-spectrum SARS-CoV-2 inhibitors, ReconnAbs, by modifying the existing non-neutralizing antibodies targeted towards the highly conserved epitopes of the SARS-CoV-2 spike (S) protein combined with a receptor-blocking component.

28 Jan 2022

Desipramine and L-cycloserine together reduce ceramide levels in the retina and enhance vision

Researchers from the University of California, Irvine have discovered that the absence of Adiponectin receptor 1 protein (AdipoR1), one of the principal enzymes regulating ceramide homeostasis in the retina, leads to an accumulation of ceramides in the retina, resulting in progressive photoreceptor cell death and ultimately vision loss.

28 Jan 2022

New approach using RNA therapeutic can fix protein problems in cystic fibrosis

The process of generating proteins from genes is akin to a factory, where workers follow a set of instructions that, ideally, are effective and clear.

27 Jan 2022

Photobiomodulation may accelerate the healing of skin damage from radiation therapy

Light therapy may accelerate the healing of skin damage from radiation therapy by up to 50%, according to a recent University at Buffalo-led study.

27 Jan 2022

Structural proteomics approaches can help in the treatment of neurodegenerative diseases

Two researchers from Skoltech and McGill University have published a review of the promising research field known as structural proteomics in the influential journal Chemical Reviews.

27 Jan 2022

Curtailed sleep may increase exercise-induced cardiac strain

In a new study, participants underwent an intense bout of exercise after both normal sleep and after three nights of curtailed sleep.

27 Jan 2022

Northwestern and partners are part of mega NIH program to investigate precision nutrition

Northwestern, the University of Chicago, Illinois Institute of Technology, University of Illinois, Chicago and Rush University are part of a mega National Institutes of Health (NIH) $170 million program that is the first comprehensive study to investigate precision nutrition.

27 Jan 2022

Blood proteoforms may help predict liver transplant rejection

Northwestern University scientists have discovered families of proteins in the body that could potentially predict which patients may reject a new organ transplant, helping inform decisions about care.

27 Jan 2022

Early-stage alveolar epithelial cell necrosis linked to COVID-19-induced acute respiratory distress syndrome

A new study analyzed whether alveolar epithelial cell necrosis at an early stage SARS-CoV-2 infection and subsequent releases of damage-associated molecular patterns could aggravate COVID-19-associated acute respiratory distress syndrome.

27 Jan 2022

Scientists identify immunogens that can elicit antibody responses against multiple SARS-CoV-2 variants

In a new study, researchers identified conserved sites in the SARS-CoV-2 spike protein using structural and sequence data, and then combined the results with existing deep mutational scanning data to design six antigens that can offer protection against significant immune escape mutations in the SARS-CoV-2 receptor-binding domain.

27 Jan 2022

Protein C News and Research

A synthesis of evidence sheds light on major immune components and mechanisms involved in COVID-19

Reduced neutralization against Omicron variant in fully immunized adolescents with BNT162b2 vaccine

γ’ fibrinogen as a disease progression marker for COVID-19

Impact of DNA clearance on mortality in patients with severe COVID-19 infections

Potential therapy candidates for patients infected with the SARS-CoV-2 Omicron variant

Study demonstrates minimally invasive, aerosolized vaccine candidate to combat SARS-CoV-2

Magnetic nanoparticles for SARS-CoV-2 and other virus detection systems

Exploring receptor-blocking conserved non-neutralizing antibodies for SARS-CoV-2 therapy

Desipramine and L-cycloserine together reduce ceramide levels in the retina and enhance vision

New approach using RNA therapeutic can fix protein problems in cystic fibrosis

Photobiomodulation may accelerate the healing of skin damage from radiation therapy

Structural proteomics approaches can help in the treatment of neurodegenerative diseases

Curtailed sleep may increase exercise-induced cardiac strain

Northwestern and partners are part of mega NIH program to investigate precision nutrition

Blood proteoforms may help predict liver transplant rejection

Early-stage alveolar epithelial cell necrosis linked to COVID-19-induced acute respiratory distress syndrome

Scientists identify immunogens that can elicit antibody responses against multiple SARS-CoV-2 variants

SARS-CoV-2 mutations and their impact on spike protein-specific T lymphocytes

Effects of multi-nutrient supplementation on COVID-19 severity in elderly patients

Targeting CHI3L1 inhibits SARS-CoV-2 variants, including Delta and Omicron

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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