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SARS-CoV-2 RNA levels, IFN-1, ISGs, and NF-κB gene responses within the respiratory tract of mild and severe COVID-19 patients

Researchers characterized the expression of IFN-1 and IFN-2, ISGs, and NF-κB in the upper respiratory tracts of patients with mild and severe COVID-19, to understand innate immune responses to SARS-CoV-2 infections.

17 Nov 2022

Study uncovers new rules for lineage progression

The hypothalamus, one of the most complex brain regions in the mammalian nervous system, contains an astonishing heterogeneity of neurons that regulate endocrine, autonomic and behavioral functions. It not only regulates food consumption, water intake, body temperature, circadian rhythm and sleep to maintain the survival of individual organisms, but also controls puberty onset and reproductive behavior to sustain the breeding population.

17 Nov 2022

Study reveals a mechanism for mitochondrial activation via nucleoid dynamics

Mitochondria, famously known as the powerhouse of the cell, are important cellular structures that are vital for their role of generating energy. Mitochondria are "dynamic", meaning they constantly fuse together and split apart. They contain a small amount of genetic information known as mitochondrial DNA (mtDNA).

17 Nov 2022

National Institutes of Health funds a five-year, $11 million initiative

The conversations between our bone and muscle change as we age, and both are the weaker for it, Medical College of Georgia scientists say.

17 Nov 2022

Study of natural killer lymphocytes transcriptionally reprogrammed by vaccinia virus

In a recent study posted to the bioRxiv* preprint server, researchers evaluated responses of natural killer (NK) lymphocytes to VACV (vaccinia virus) infections in vivo.

16 Nov 2022

SARS-CoV-2 ‘Deltacron’ variant exhibits immune-escape properties similar to Omicron BA.1

The SARS-CoV-2 Deltacron does not exhibit higher transmissibility or immune evasion than the Omicron BA.1 variant.

16 Nov 2022

Researchers discover the mechanism for heart complications from immune checkpoint inhibitors

Myocarditis is a complication that can occur in cancer patients treated with immune checkpoint inhibitors.

16 Nov 2022

Key Alzheimer’s gene alters the way cholesterol moves around the brain, research finds

A gene recognized as the strongest risk factor for Alzheimer's disease (AD) alters the way cholesterol moves around the brain and as we age, this altered movement likely contributes to loss of learning and memory, a team of researchers from the Icahn School of Medicine at Mount Sinai and the Massachusetts Institute of Technology reports.

16 Nov 2022

Machine learning algorithm predicts a tumor’s response to immune checkpoint blockade

Predicting which patients will respond well to treatment is a quandary that has plagued the field of cancer immunotherapy for more than four decades.

16 Nov 2022

NIH researchers identify differences in gene activity in the brains of individuals with ADHD

Researchers at the National Institutes of Health have successfully identified differences in gene activity in the brains of people with attention deficit hyperactivity disorder (ADHD).

16 Nov 2022

Research findings could bolster the effectiveness of immune-checkpoint therapy

Immune checkpoint inhibitors such as Keytruda and Opdivo work by unleashing the immune system's T cells to attack tumor cells.

16 Nov 2022

Research reveals new treatment avenue for pediatric high grade gliomas harboring a genetic mutation

Researchers at the University of Michigan Rogel Cancer Center have identified a novel treatment approach to an aggressive type of pediatric brain cancer, using therapies already approved to treat cancer.

16 Nov 2022

Novel nasal vaccine approach induces potent lung immunity and protection against SARS-CoV-2

Researchers from the Centenary Institute and the University of Sydney have developed a new nasal vaccination strategy that induces potent lung immunity and protection against the SARS-CoV-2 coronavirus.

16 Nov 2022

Nerve cell discovery may improve treatment options for patients with neurodegenerative diseases

A discovery that may improve treatment options for patients with neurodegenerative diseases has been made by scientists at King's College London and the University of Bath in the UK.

16 Nov 2022

Researchers identify potential lead compounds for the treatment of neuropsychiatric disorders

Currently, various classes of drugs are available for the treatment of mental illnesses - such as depression and anxiety disorders. However, although these drugs confer benefits, they are also associated with adverse side-effects.

15 Nov 2022

COVID-19 mRNA boosters induce robust but non-durable immune response in the elderly

A study published in the journal Frontiers in Immunology describes that the third booster dose of coronavirus disease 2019 (COVID-19) effectively induces an immune response against immunologically more fit variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the immunity induced by the booster vaccination is transient and gradually declines over time.

15 Nov 2022

Protein levels in lung tumors may predict prognosis, improve treatment and diagnostics

Lung cancer is the leading cause of cancer deaths globally and a top cause of cancer deaths in the Military Health System.

15 Nov 2022

New, automated system calculates metabolic tumor volume in diffuse large B-cell lymphoma

Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have developed a new, automated way to calculate metabolic tumor volume (MTV) in diffuse large B-cell lymphoma (DLBCL).

15 Nov 2022

Researchers make first bone marrow 'organoids' to capture key features of human bone marrow

Scientists from Oxford University and the University of Birmingham have made the first bone marrow 'organoids' that capture the key features of human bone marrow.

15 Nov 2022

Development of a potent, broadly protective vaccine against all SARS-CoV-2 variants

In a recent study published in the journal npj Vaccines, researchers in China designed, produced, and evaluated the neutralization efficacy of a recombinant coronavirus disease 2019 (COVID-19) vaccine containing four hot-spot substitution mutations based on a prefusion-stabilized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S) trimer.

15 Nov 2022

B Cell News and Research

SARS-CoV-2 RNA levels, IFN-1, ISGs, and NF-κB gene responses within the respiratory tract of mild and severe COVID-19 patients

Study uncovers new rules for lineage progression

Study reveals a mechanism for mitochondrial activation via nucleoid dynamics

National Institutes of Health funds a five-year, $11 million initiative

Study of natural killer lymphocytes transcriptionally reprogrammed by vaccinia virus

SARS-CoV-2 ‘Deltacron’ variant exhibits immune-escape properties similar to Omicron BA.1

Researchers discover the mechanism for heart complications from immune checkpoint inhibitors

Key Alzheimer’s gene alters the way cholesterol moves around the brain, research finds

Machine learning algorithm predicts a tumor’s response to immune checkpoint blockade

NIH researchers identify differences in gene activity in the brains of individuals with ADHD

Research findings could bolster the effectiveness of immune-checkpoint therapy

Research reveals new treatment avenue for pediatric high grade gliomas harboring a genetic mutation

Novel nasal vaccine approach induces potent lung immunity and protection against SARS-CoV-2

Nerve cell discovery may improve treatment options for patients with neurodegenerative diseases

Researchers identify potential lead compounds for the treatment of neuropsychiatric disorders

COVID-19 mRNA boosters induce robust but non-durable immune response in the elderly

Protein levels in lung tumors may predict prognosis, improve treatment and diagnostics

New, automated system calculates metabolic tumor volume in diffuse large B-cell lymphoma

Researchers make first bone marrow 'organoids' to capture key features of human bone marrow

Development of a potent, broadly protective vaccine against all SARS-CoV-2 variants

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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