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Novartis Prizes for Immunology to be awarded to six scientists for groundbreaking research

Today Novartis announced that six scientists will receive the 2016 Novartis Prizes for Immunology at the upcoming 16th International Congress of Immunology in Melbourne, Australia on Aug 22, 2016.

17 Aug 2016

IRB Barcelona scientists rediscover utility of disordered proteins as therapeutic targets

Prostate cancer, Alzheimer's, Parkinson's...these three diseases are associated with proteins that share a common feature, namely disordered regions that have no apparent rigid three-dimensional structure.

16 Aug 2016

Study shows leptomeningeal metastases more prevalent in NSCLC patients with EGFR mutations

Leptomeningeal metastases (LM), a devastating complication and predictor of poor survival in lung cancer patients, was found to be more prevalent in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations.

16 Aug 2016

NIH funds collaborative project to develop better vaccine adjuvants for many diseases

Dr. Qizhi Cathy Yao, professor of surgery, molecular virology and microbiology, and pathology & immunology at Baylor College of Medicine, has been awarded a National Institutes of Health grant to fund a collaborative project with Molecular Express, Inc.

12 Aug 2016

Glia cells may play role in regulating sugar intake into the brain, experts report

Researchers at Technical University of Munich discovered that our brain actively takes sugar from the blood. Prior to this, researchers around the world had assumed that this was a purely passive process.

12 Aug 2016

FDA grants Orphan Drug Designation to CD4CAR therapy for treatment of peripheral T-cell lymphoma

iCell Gene Therapeutics today (Aug. 11) announced that the Food and Drug Administration has granted Orphan Drug Designation for its chimeric antigen receptor engineered T-cells directed against the target protein CD4 (CD4CAR) for the treatment of peripheral T-cell lymphoma (PTCL).

12 Aug 2016

Drug approved for treatment of vulvovaginal atrophy shows no added benefit in post-menopausal women

Ospemifene (tradename: Senshio) is approved for the treatment of moderate to severe symptomatic vulvovaginal atrophy (VVA) in post-menopausal women who are not candidates for local vaginal oestrogen therapy.

11 Aug 2016

Scientists clarify how tumour cells kill specific cells in vascular wall to establish metastases

Many cancers only become a mortal danger if they form metastases elsewhere in the body. Such secondary tumours are formed when individual cells break away from the main tumour and travel through the bloodstream to distant areas of the body.

11 Aug 2016

Novel computational analysis of prostate cancer suggests potential targets for therapy

Cancer researchers have applied a comprehensive set of analytical tools to lethal cases of metastatic prostate cancer, yielding a detailed map of the complex networks of interactions among genes and proteins that enable prostate cancer cells to proliferate and evade treatment.

11 Aug 2016

Gene mutation linked to impulsive drunken behaviour shields bearers from obesity, insulin resistance

University of Helsinki researchers have previously demonstrated that a point mutation in a gene of serotonin 2B receptor can render the carrier prone to impulsive behaviour, particularly when drunk.

10 Aug 2016

Research findings could provide framework for understanding fertilization mechanism

A Japanese research group has determined the crystal structure of the JUNO protein, an egg surface protein essential for fertilization. These structure-based mutational analyses elucidated a mechanism of the interaction between egg (JUNO protein) and sperm (IZUMO1) on a molecular level.

9 Aug 2016

Study finds no major difference in effectiveness of two classes of drugs in peritoneal dialysis patients

With cardiovascular disease being the No. 1 cause of death in end-stage kidney disease patients on peritoneal dialysis, a new study examined two classes of medications commonly prescribed to prevent cardiovascular events in these patients and found no significant difference in outcomes.

9 Aug 2016

Scientists unravel effect of prion proteins on the nerves

Ever since the prion gene was discovered in 1985, its role and biological impact on the neurons has remained a mystery.

9 Aug 2016

Study reveals needle biopsy hormone receptor testing for DCIS wastes millions

For patients with the most common type of noninvasive breast cancer, routine testing for estrogen and progesterone receptors in tissue taken at the first "needle" biopsy is both unnecessary and wasteful, according to results of a study led by Johns Hopkins pathologists.

9 Aug 2016

Novel compound holds potential for next-generation prostate cancer treatment

In the search for new ways to attack recurrent prostate cancer, researchers at Duke Health report that a novel compound appears to have a unique way of blocking testosterone from fueling the tumors in mice.

8 Aug 2016

Activation of specific neural circuit can inhibit binge-like eating behavior in mice

While binge eating affects about 10 percent of adults in the United States, the neurobiological basis of the disease is unclear.

8 Aug 2016

Researchers discover olfactory receptors in human muscle cells of bronchi

Researchers identified two types of olfactory receptors in human muscle cells of bronchi. If those receptors are activated by binding an odorant, bronchi dilate and contract - a potential approach for asthma therapy.

8 Aug 2016

Novel therapeutic strategy could target multiple aspects of Alzheimer's disease

Therapeutic strategies targeting Alzheimer's disease (AD)-related molecule β-amyloid (Aβ), Tau protein and BACE enzyme have been recently explored. However the therapeutic efficacy for a single target is not ideal.

8 Aug 2016

Scientists make major advance in understanding how stem cells become specialized

Scientists at Sanford Burnham Prebys Medical Discovery Institute have made a major advance in understanding how the cells of an organism, which all contain the same genetic information, come to be so diverse.

5 Aug 2016

Botulinum toxins may cause remote effects by moving between neurons

The botulinum toxins are among the deadliest substances on Earth, and two specific toxins — including the popular drug Botox — have multiple uses for treating many neuromuscular conditions, including frown lines, disabling muscle spasms and migraine headaches.

5 Aug 2016

Receptor News and Research

Novartis Prizes for Immunology to be awarded to six scientists for groundbreaking research

IRB Barcelona scientists rediscover utility of disordered proteins as therapeutic targets

Study shows leptomeningeal metastases more prevalent in NSCLC patients with EGFR mutations

NIH funds collaborative project to develop better vaccine adjuvants for many diseases

Glia cells may play role in regulating sugar intake into the brain, experts report

FDA grants Orphan Drug Designation to CD4CAR therapy for treatment of peripheral T-cell lymphoma

Drug approved for treatment of vulvovaginal atrophy shows no added benefit in post-menopausal women

Scientists clarify how tumour cells kill specific cells in vascular wall to establish metastases

Novel computational analysis of prostate cancer suggests potential targets for therapy

Gene mutation linked to impulsive drunken behaviour shields bearers from obesity, insulin resistance

Research findings could provide framework for understanding fertilization mechanism

Study finds no major difference in effectiveness of two classes of drugs in peritoneal dialysis patients

Scientists unravel effect of prion proteins on the nerves

Study reveals needle biopsy hormone receptor testing for DCIS wastes millions

Novel compound holds potential for next-generation prostate cancer treatment

Activation of specific neural circuit can inhibit binge-like eating behavior in mice

Researchers discover olfactory receptors in human muscle cells of bronchi

Novel therapeutic strategy could target multiple aspects of Alzheimer's disease

Scientists make major advance in understanding how stem cells become specialized

Botulinum toxins may cause remote effects by moving between neurons

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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