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Breakthrough in cancer therapy targets key protein interaction to suppress tumors

Researchers at the Francis Crick Institute and Vividion Therapeutics have identified chemical compounds that can precisely block the interaction between the major cancer-driving gene RAS, and a key pathway for tumor growth.

9 Oct 2025

The ISSCR releases new resource to accelerate the development of PSC-derived therapies

The International Society for Stem Cell Research (ISSCR) is proud to announce the release of Best Practices for the Development of Pluripotent Stem Cell-Derived Cellular Therapies, a comprehensive, interactive new resource designed to accelerate the translation of human pluripotent stem cell (PSC)-derived therapies into clinical trials and commercial use.

9 Oct 2025

Quitting smoking after cancer diagnosis significantly extends survival

Around 25% of people with cancer in the U.S. are active smokers when they are diagnosed, and studies have found that many of them continue to smoke during treatment.

9 Oct 2025

Engineered virus therapy triggers powerful immune responses in glioblastoma

A new study led by Break Through Cancer's Accelerating Glioblastoma (GBM) Therapies Through Serial Biopsies TeamLab has revealed that an engineered virus therapy, CAN-3110, triggered powerful immune responses deep inside glioblastoma tumors that were invisible to standard imaging like MRI, according to early analyses of two patients with recurrent GBM.

9 Oct 2025

University Of California researchers, patients wary of Trump cuts even as some dollars flow again

In August, an 80-year-old woman walked into the emergency room at Ronald Reagan UCLA Medical Center. She was lucid but experiencing a stroke.

9 Oct 2025

Repeated sampling offers insight into glioblastoma therapy response

A multi-institutional study from the Accelerating GBM Therapies Through Serial Biopsies TeamLab, led by investigators from the Mass General Brigham Cancer Institute, found that serially testing tumor samples can help detect when a cancer treatment is activating the immune system in recurrent glioblastoma (GBM), even when traditional imaging measures cannot.

8 Oct 2025

Engineered Salmonella therapy delivers immune payloads to combat cancer

A new research paper was published in Volume 16 of Oncotarget on October 6, 2025, titled "ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response."

8 Oct 2025

New dual-target vaccine shows promise against typhoid and Salmonella

Researchers at the University of Maryland School of Medicine's Center for Vaccine Development and Global Health (CVD) have completed a successful Phase 1 clinical trial of a novel vaccine designed to protect against both typhoid fever and invasive non-typhoidal Salmonella--two major causes of illness and death among children in sub-Saharan Africa.

8 Oct 2025

Engineered CAR-NK cells show enhanced cancer killing and immune evasion

One of the newest weapons that scientists have developed against cancer is a type of engineered immune cell known as CAR-NK (natural killer) cells. Similar to CAR-T cells, these cells can be programmed to attack cancer cells.

8 Oct 2025

Whole genome sequencing may guide care for thousands of breast cancer patients

Whole genome sequencing offered to breast cancer patients is likely to identify unique genetic features that could either guide immediate treatment or help match patients to clinical trials for over 15,000 women a year, say scientists at the University of Cambridge.

7 Oct 2025

Unlocking the mysteries of treatment-resistant prostate cancer

Advances in prostate cancer early detection and treatment have improved outcomes in men diagnosed with the disease.

7 Oct 2025

New drug combination could delay the progression of advanced prostate cancer

A new drug combination could significantly delay the progression of a life-threatening form of prostate cancer in men with specific genetic mutations, finds a major international trial led by UCL researchers.

7 Oct 2025

New ASPIRE trial tests chemotherapy combination for advanced prostate cancer

The Alliance for Clinical Trials in Oncology has launched the ASPIRE trial-a large-scale, Phase III clinical study investigating whether adding chemotherapy to current standard treatments can extend survival for men living with advanced prostate cancer.

6 Oct 2025

DKMS advances blood cancer research with groundbreaking ASAP study

The selection of patients for allo-HSCT and the best approach to bridging patients to transplantation is continuously discussed by experts.

6 Oct 2025

New intervention improves pediatricians' ability to counsel families on early peanut introduction

Results from a randomized clinical trial published in Pediatrics show that pediatricians who received targeted educational and clinical decision-support tools were significantly more likely to advise parents to introduce peanut-containing foods early – an approach recommended by national prevention guidelines but often underused in practice.

6 Oct 2025

Azelastine nasal spray prevents COVID-19 and rhinovirus infections

Researchers discuss the effects of azelastine nasal spray on the rate of SARS-CoV-2 infection as compared to placebo.

6 Oct 2025

Simple tools increase pediatrician compliance with early peanut allergy prevention guidelines

A few easy-to-implement tools - a training video, electronic health record prompts and handouts for families - greatly increased how often pediatricians recommended early peanut introduction to infants, reports a new clinical study led by Northwestern University and Ann & Robert H. Lurie Children's Hospital of Chicago.

6 Oct 2025

Study reveals new strategy to block TNBC metastasis and restore chromosomal stability

Triple negative breast cancer (TNBC) is one of the most aggressive and hardest forms of breast cancer to treat, but a new study led by Weill Cornell Medicine suggests a surprising way to stop it from spreading. Researchers have discovered that an enzyme called EZH2 drives TNBC cells to divide abnormally, which enables them to relocate to distant organs.

6 Oct 2025

Innovative topical cream relieves chemotherapy-induced peripheral neuropathy

Most patients receiving chemotherapy with taxanes or platinum salts develop pain and loss of sensitivity in their hands and feet—a severe side effect that can interfere with proper treatment.

3 Oct 2025

How gluten harms some people but helps others

New insights reveal gluten's health potential, highlighting beneficial peptides and innovative methods to enhance wheat safety for sensitive individuals.

3 Oct 2025