Clinical Trial News and Research

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Arginine dentifrices reduce dental caries in children with active caries

The International Association for Dental, Oral, and Craniofacial Research (IADR) and the American Association for Dental, Oral, and Craniofacial Research (AADOCR) have announced the publication of a new study in JDR Clinical & Translational Research that demonstrates that arginine dentifrices reduce dental caries in children with active caries as much as, or more than, a sodium fluoride dentifrice, depending on the arginine concentration.

13 Aug 2025

Early use of risdiplam in newborns with SMA shows improvements in motor development

Spinal muscular atrophy (SMA) is a rare genetic condition that causes progressive muscle weakness, which, when untreated, prevents infants with the most severe form from gaining motor development - never gaining the ability to sit - and typically leads to death before 2 years of age.

13 Aug 2025

Griffith University launches groundbreaking treatment trial for spinal cord injury

A Phase 1 human clinical trial to treat chronic spinal cord injury, the first of its kind in the world, has commenced to test the efficacy and safety of a revolutionary new treatment using nasal cells.

13 Aug 2025

New drug-releasing system eliminates tumors in 82% of high-risk bladder cancer patients

A new drug-releasing system, TAR-200, eliminated tumors in 82% of patients in a phase 2 clinical trial for individuals with high-risk non-muscle-invasive bladder cancer whose cancer had previously resisted treatment.

13 Aug 2025

Conch shell blowing lowers apnea events during REM sleep

Shankh blowing shows promise in alleviating sleep apnea, with significant improvements in sleep quality and reductions in daytime sleepiness after six months.

13 Aug 2025

New research explores foot positioning to treat knee osteoarthritis

Gait analysis and pain measures show that subtly adjusting the angle of the foot during walking may reduce knee pain caused by osteoarthritis. This approach may also slow progression of the condition, an uncurable disease in which the cartilage cushion inside a joint breaks down.

13 Aug 2025

SNMMI launches AI-powered platform to connect patients with radiopharmaceutical trials

The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is proud to announce the launch of the Global Radiopharmaceutical Trial Finder a revolutionary, AI-powered platform designed to help researchers, clinicians and patients instantly discover radiopharmaceutical clinical trials that meet their specific needs.

12 Aug 2025

Personalized gait retraining reduces pain and slows knee damage in osteoarthritis

Nearly a quarter of people over the age of 40 experience painful osteoarthritis, making it a leading cause of disability in adults.

12 Aug 2025

Long COVID linked to lasting financial hardship and work disruption

While the economic impact of the COVID-19 pandemic continues to be widely studied and debated, the financial toll of the COVID-19 pandemic for individual patients is less understood.

12 Aug 2025

Adding MET inhibitor enhances immune response against small cell lung tumors

Adding a MET gene inhibitor enhances the effect of combined chemotherapy and immunotherapy in small cell lung cancer (SCLC), according to a multicenter study led by the Hospital del Mar Research Institute, in collaboration with researchers from the CIBERONC cancer research network.

12 Aug 2025

Sunil Shah and Dr Catherine Elton join Atelerix's Board to drive global commercial expansion

Atelerix, a biotech company revolutionizing cell preservation and biological transport with its pioneering hydrogel encapsulation technology, today announced the appointments of Sunil Shah as Chair of the Board and Dr Catherine Elton as Non-Executive Director.

12 Aug 2025

Fetal procedure dramatically reduces mortality in high-risk Vein of Galen Malformation cases

Building upon the success of the first in utero brain surgery for Vein of Galen Malformation (VOGM) reported in 2023, new data published today in JAMA provides further evidence for the potential use of fetal embolization for this condition.

11 Aug 2025

New biomarker may be the first specific and quantifiable indicator for confirming long COVID

Researchers from the Translational Genomics Research Institute (TGen), part of City of Hope, and the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center have identified a potential biomarker for long COVID.

11 Aug 2025

Ancient shankh blowing practice found to improve sleep and alertness in OSA patients

People who practised blowing through a conch shell regularly for six months experienced a reduction in their symptoms of obstructive sleep apnoea (OSA), according to a small randomised controlled trial published today (Monday) in ERJ Open Research.

10 Aug 2025

Early clinical trial supports MASL as a targeted oral cancer treatment

Rowan University and Sentrimed, a clinical-stage biopharmaceutical company focused on developing safer, orally dosed oncology therapies, today announced results from a National Cancer Institute (NCI) funded clinical trial evaluating MASL in patients with oral squamous cell carcinoma (OSCC).

8 Aug 2025

Lithium deficiency emerges as a hidden driver of Alzheimer’s

What is the earliest spark that ignites the memory-robbing march of Alzheimer’s disease? Why do some people with Alzheimer’s-like changes in the brain never go on to develop dementia? These questions have bedeviled neuroscientists for decades.

8 Aug 2025

Suicide-specific mobile app offers lifesaving support after psychiatric discharge

A mobile phone app designed to deliver suicide-specific therapy reduced suicidal behavior among high-risk psychiatric inpatients, according to a new study by scientists at Yale School of Medicine and The Ohio State University Wexner Medical Center and College of Medicine.

8 Aug 2025

Early treatment withdrawal offers safety and savings for patients with rare kidney disease

Early withdrawal of a treatment for patients with a rare kidney disease is possible without relapse, safer for patients and saves the NHS millions of pounds, new research has revealed.

7 Aug 2025

Asthma drug found to prevent food allergy reactions in mice

A drug already FDA-approved for asthma was found to nearly eliminate life-threatening allergic reactions to food allergens in mice - a breakthrough that could lead to new protection for millions of people living with food allergies, reports a new Northwestern Medicine study.

7 Aug 2025

Patient numbers at NIH hospital have plummeted under Trump, jeopardizing care

The number of people receiving treatment at the National Institutes of Health Clinical Center — the renowned research hospital that cares for patients with rare or life-threatening diseases — has tumbled under the second Trump administration, according to government documents and interviews with current and former NIH employees.

7 Aug 2025

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Clinical Trial News and Research

Arginine dentifrices reduce dental caries in children with active caries

Early use of risdiplam in newborns with SMA shows improvements in motor development

Griffith University launches groundbreaking treatment trial for spinal cord injury

New drug-releasing system eliminates tumors in 82% of high-risk bladder cancer patients

Conch shell blowing lowers apnea events during REM sleep

New research explores foot positioning to treat knee osteoarthritis

SNMMI launches AI-powered platform to connect patients with radiopharmaceutical trials

Personalized gait retraining reduces pain and slows knee damage in osteoarthritis

Long COVID linked to lasting financial hardship and work disruption

Adding MET inhibitor enhances immune response against small cell lung tumors

Sunil Shah and Dr Catherine Elton join Atelerix's Board to drive global commercial expansion

Fetal procedure dramatically reduces mortality in high-risk Vein of Galen Malformation cases

New biomarker may be the first specific and quantifiable indicator for confirming long COVID

Ancient shankh blowing practice found to improve sleep and alertness in OSA patients

Early clinical trial supports MASL as a targeted oral cancer treatment

Lithium deficiency emerges as a hidden driver of Alzheimer’s

Suicide-specific mobile app offers lifesaving support after psychiatric discharge

Early treatment withdrawal offers safety and savings for patients with rare kidney disease

Asthma drug found to prevent food allergy reactions in mice

Patient numbers at NIH hospital have plummeted under Trump, jeopardizing care

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