Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Researchers figure out the precise mechanics involved in cell motility

Theoretical physicists from Berlin teamed up with experimental physicists from Munich to determine the precise mechanics involved in cell motility. The findings were published in the journal Proceedings of the National Academy of Sciences.

18 Jan 2021

Study provides a mathematical description of how tumor metastasis starts

A scientific study carried out by the Universidad Carlos III de Madrid and the Universidad Complutense de Madrid (UCM) has produced a mathematical description of the way in which a tumor invades the epithelial cells and automatically quantifies the progression of the tumor and the remaining cell islands after its progression.

18 Jan 2021

Study reveals significant role of ADAMTS1 protein in uveal melanoma

Scientists from the University of Granada and GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), in a study led by Juan Carlos Rodríguez-Manzaneque, have demonstrated the significant role of a protein called ADAMTS1 in uveal melanoma, one of the rarest and most aggressive cancers that exist, which develops in the eye.

15 Jan 2021

New cancer models mimic aspects of mechanical environment within the body

As cancer and tumor cells move inside the human body, they impart and are subject to mechanical forces.

15 Jan 2021

New cellular pathway limits growth and spread of brain tumors

Researchers at McGill University have identified a new cellular pathway that limits the growth and spread of brain tumors by controlling the recycling of cell surface receptor proteins.

14 Jan 2021

The Cancer Microbiome Atlas gives clearer picture of microbiota living in organs

Biomedical engineers at Duke University have devised an algorithm to remove contaminated microbial genetic information from The Cancer Genome Atlas (TCGA).

13 Jan 2021

Researchers investigate protein phosphatase to identify new treatments for cancer, other diseases

The abundant presence of an enzyme known as low molecular weight protein tyrosine phosphatase (LMWPTP) in tumor cells has long been considered an indicator of cancer aggressiveness and metastatic potential.

13 Jan 2021

Researchers discover a new approach to inhibit intrahepatic cholangiocarcinoma

Reprogramming the rich connective tissue microenvironment of a liver cancer known as intrahepatic cholangiocarcinoma (ICC) inhibits its progression and resistance to standard chemotherapy in animal models, researchers from Massachusetts General Hospital have found.

12 Jan 2021

Study investigates the metabolites involved in growth and spread of melanoma

The first step in treating cancer is understanding how it starts, grows and spreads throughout the body. A relatively new cancer research approach is the study of metabolites, the products of different steps in cancer cell metabolism, and how those substances interact.

12 Jan 2021

UTSW study uncovers a gene linked to growth of breast cancer

A team of UT Southwestern researchers has identified a gene involved in the growth of breast cancer, a finding that could lead to potential new targets for treatment.

12 Jan 2021

ARID1A gene in ovarian cancer plays a role in the regulation of metabolism

Mutations that inactivate the ARID1A gene in ovarian cancer increase utilization of the glutamine amino acid making cancer cells dependent on glutamine metabolism, according to a study by The Wistar Institute published online in Nature Cancer.

12 Jan 2021

Researchers develop deep learning model to predict occult peritoneal metastasis in gastric cancer patients

Stomach cancer, or gastric cancer, is a common gastrointestinal malignancy. Peritoneal metastasis occurs in a majority of patients with advanced stomach cancer and is considered as an aggressive disease with poor outcomes.

7 Jan 2021

Researchers discover new metabolic vulnerability in a highly aggressive form of lung cancer

Researchers at the Children's Medical Center Research Institute at UT Southwestern (CRI) have discovered a new metabolic vulnerability in a highly aggressive form of non-small cell lung cancer (NSCLC).

5 Jan 2021

Inhibition of blood clotting factor reduces the formation of brain metastases in mice

Brain metastases can only develop if cancer cells first exit the fine blood vessels and enter into the brain tissue.

5 Jan 2021

Researchers develop α-emitting cancer therapy using a novel drug targeting LAT1

A cancer-specific L-type amino acid transporter 1 (LAT1) is highly expressed in cancer tissues.

4 Jan 2021

Researchers discover how chromosomal instability allows cancer cells to avoid immune defenses

Cancer cells are known for spreading genetic chaos. As cancer cells divide, DNA segments and even whole chromosomes can be duplicated, mutated, or lost altogether. This is called chromosomal instability, and scientists at Memorial Sloan Kettering have learned that it is associated with cancer's aggressiveness.

28 Dec 2020

Study reveals the role of SETD2 protein in cancer cells, cell migration, and autophagy

SETD2 is a protein well known as a chromatin remodeler, one that helps turn genes on or off by modifying histone proteins in the nucleus of the cell.

24 Dec 2020

Gene-regulating snippet of RNA may contribute to breast cancer metastasis

Cold Spring Harbor Laboratory (CSHL) scientists have discovered a gene-regulating snippet of RNA that may contribute to the spread of many breast cancers.

22 Dec 2020

New understanding of physical properties of chromatin may show how genome is encoded and decoded

University of Alberta researchers have found an answer to a fundamental question in genomic biology that has eluded scientists since the discovery of DNA: Within the nucleus of our cells, is the complex package of DNA and proteins called chromatin a solid or a liquid?

20 Dec 2020

FAT1 mutations act as tumor suppressor and prevent cancer development, indicates study

Cancer metastasis, which is the dissemination of tumor cells into distant organs, is the leading cause of mortality in cancer patients. To undergo metastasis, cells must leave the primary tumor, circulate into the blood, colonize distant organs, and form distant metastasis.

17 Dec 2020

Metastasis News and Research

Further Reading

Researchers figure out the precise mechanics involved in cell motility

Study provides a mathematical description of how tumor metastasis starts

Study reveals significant role of ADAMTS1 protein in uveal melanoma

New cancer models mimic aspects of mechanical environment within the body

New cellular pathway limits growth and spread of brain tumors

The Cancer Microbiome Atlas gives clearer picture of microbiota living in organs

Researchers investigate protein phosphatase to identify new treatments for cancer, other diseases

Researchers discover a new approach to inhibit intrahepatic cholangiocarcinoma

Study investigates the metabolites involved in growth and spread of melanoma

UTSW study uncovers a gene linked to growth of breast cancer

ARID1A gene in ovarian cancer plays a role in the regulation of metabolism

Researchers develop deep learning model to predict occult peritoneal metastasis in gastric cancer patients

Researchers discover new metabolic vulnerability in a highly aggressive form of lung cancer

Inhibition of blood clotting factor reduces the formation of brain metastases in mice

Researchers develop α-emitting cancer therapy using a novel drug targeting LAT1

Researchers discover how chromosomal instability allows cancer cells to avoid immune defenses

Study reveals the role of SETD2 protein in cancer cells, cell migration, and autophagy

Gene-regulating snippet of RNA may contribute to breast cancer metastasis

New understanding of physical properties of chromatin may show how genome is encoded and decoded

FAT1 mutations act as tumor suppressor and prevent cancer development, indicates study

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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