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Dopamine neurons may play a bigger role in motor control than previously thought

Dopamine: It's not just for rewards anymore. In a new Northwestern University-led study, researchers identified and recorded from three genetic subtypes of dopamine neurons in the midbrain region of a mouse model.

3 Aug 2023

Study sheds light on mechanisms behind a rare disease found almost exclusively in boys

A University of Ottawa-led research team has published rigorous new research that advances a quest to understand a puzzling – and heartbreaking – ultra-rare disease that's found almost exclusively in boys.

3 Aug 2023

Can genome editing transform ocular disease treatment?

The discovery and development of gene-editing technologies and their applications in managing ocular diseases.

3 Aug 2023

Study reveals two key mechanisms underlying high risks from lung infections in Down syndrome

Individuals with Down syndrome, the genetic condition caused by triplication of human chromosome 21, also known as trisomy 21, display a very high risk of hospitalization and mortality after developing lung infections.

2 Aug 2023

TTUHSC researcher receives $1.76 million grant to investigate new pancreatic cancer treatment

With a survival rate in the single digits, pancreatic ductal adenocarcinoma (PDAC) is highly lethal. In fact, by the time PDAC is clinically diagnosed, it is already considered incurable via surgery or other means in up to 90% of patients.

2 Aug 2023

Monoclonal antibody shows promise in slowing progression of ALS

New research reveals a type of monoclonal antibody already tested in certain forms of cancer may be a promising treatment in stopping the progression of amyotrophic lateral sclerosis, or ALS, a fatal neurodegenerative disease.

31 Jul 2023

Human senescent fibroblasts trigger fibrogenic reaction in the lungs of immunodeficient mice

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, "Human senescent fibroblasts trigger progressive lung fibrosis in mice."

31 Jul 2023

Researchers investigate the efficacy of a novel intra-tumoral drug delivery carrier in treating oral squamous cell carcinoma

Researchers investigated the efficacy of a novel intra-tumoral drug delivery carrier in treating oral squamous cell carcinoma.

31 Jul 2023

Novel vaccine targets inflamed brain cells in Alzheimer's to modify the course of disease

A novel vaccine that targets inflamed brain cells associated with Alzheimer's disease may hold the key to potentially preventing or modifying the course of the disease, according to preliminary research presented at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions 2023.

31 Jul 2023

Assessing the quality of proteins and the unique benefits of pulses

Researchers discuss the methods available to assess protein quality while also assessing the benefits of plant proteins to human health.

31 Jul 2023

Stem cells offer new hope for Crohn's disease treatment

Research from Ann & Robert H. Lurie Children's Hospital of Chicago found that direct injection of neonatal mesenchymal stem cells, derived from heart tissue discarded during surgery, reduces intestinal inflammation and promotes wound healing in a mouse model of Crohn's disease-like ileitis, an illness marked by chronic intestinal inflammation and progressive tissue damage.

28 Jul 2023

Enhanced light sensitivity may worsen Alzheimer's symptoms

New Alzheimer’s research from UVA Health suggests that enhanced light sensitivity may contribute to “sundowning” – the worsening of symptoms late in the day – and spur sleep disruptions thought to contribute to the disease’s progression.

28 Jul 2023

Researchers discover potential new treatment for rhabdomyosarcoma

Researchers from the Leibniz Institute on Aging in Jena and the Brandenburg University of Technology Cottbus-Senftenberg have discovered a novel treatment approach for soft tissue tumors, which are frequently occurring in children and are often malignant.

26 Jul 2023

Secretion of more immune protein protects females against obesity

Associated with poorer mental health outcomes and reduced quality of life, obesity is on the rise in the United States. Currently, more than 30% of American adults are classified as obese.

25 Jul 2023

New drug delivery system may revolutionize treatment of ectopic pregnancy

Researchers in the Oregon State University College of Pharmacy have developed a drug delivery system that shows promise for greatly enhancing the efficacy of the medicine given to women with the life-threatening condition of ectopic pregnancy, which occurs when a fertilized egg implants somewhere other than the lining of the uterus.

24 Jul 2023

Researchers develop novel system to identify new therapeutics for familial hypercholesterolemia

The Mona Lisa, painted by the Italian artist Leonardo da Vinci, is one of the most recognizable paintings in the world. But many people would be surprised to learn that this painting offers the first evidence of a disease called familial hypercholesterolemia (FH).

20 Jul 2023

Study reveals molecular mechanisms of H. pylori-induced gastric carcinogenesis

Helicobacter pylori (H. pylori) infections are commonly associated with abdominal pain, bloating, and acidity. Clinical evidence suggests that infection with H. pylori cagA+ strains dramatically increases the risk of developing gastric cancer.

18 Jul 2023

Study establishes new link between genomic instability and bacterial protein in the urogenital tract

A team of researchers from the University of Maryland School of Maryland's (UMSOM) Institute of Human Virology (IHV), a Center of Excellence of the Global Virus Network (GVN), published new findings that emphasize the crucial role of the urinary and genital tract microbiota in adverse pregnancy outcomes and genomic instability that originate in the womb during fetal development.

17 Jul 2023

Study reveals immune dysregulation in Down syndrome and potential therapeutic strategy

People with Down syndrome, the condition caused by an extra copy of chromosome 21, or trisomy 21, display chronic dysregulation of their immune system, which can contribute to high rates of autoimmune conditions and severe complications from respiratory infections.

17 Jul 2023

New study reveals mast cells' surprising role in allergy-related avoidance behavior

Researchers showed that mast cells and IgE are the key orchestrators of antigen-specific avoidance.

14 Jul 2023

Mouse Model News and Research

Dopamine neurons may play a bigger role in motor control than previously thought

Study sheds light on mechanisms behind a rare disease found almost exclusively in boys

Can genome editing transform ocular disease treatment?

Study reveals two key mechanisms underlying high risks from lung infections in Down syndrome

TTUHSC researcher receives $1.76 million grant to investigate new pancreatic cancer treatment

Monoclonal antibody shows promise in slowing progression of ALS

Human senescent fibroblasts trigger fibrogenic reaction in the lungs of immunodeficient mice

Researchers investigate the efficacy of a novel intra-tumoral drug delivery carrier in treating oral squamous cell carcinoma

Novel vaccine targets inflamed brain cells in Alzheimer's to modify the course of disease

Assessing the quality of proteins and the unique benefits of pulses

Stem cells offer new hope for Crohn's disease treatment

Enhanced light sensitivity may worsen Alzheimer's symptoms

Researchers discover potential new treatment for rhabdomyosarcoma

Secretion of more immune protein protects females against obesity

New drug delivery system may revolutionize treatment of ectopic pregnancy

Researchers develop novel system to identify new therapeutics for familial hypercholesterolemia

Study reveals molecular mechanisms of H. pylori-induced gastric carcinogenesis

Study establishes new link between genomic instability and bacterial protein in the urogenital tract

Study reveals immune dysregulation in Down syndrome and potential therapeutic strategy

New study reveals mast cells' surprising role in allergy-related avoidance behavior

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