Red Blood Cells News and Research

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Patients with sickle cell disease have sleep disordered breathing problem

A new study in the Journal of Clinical Sleep Medicine revealed that 44 percent of adults with sickle cell disease who report trouble sleeping actually have a clinical diagnosis of sleep disordered breathing, including sleep apnea, which lowers their oxygen levels at night.

26 Mar 2015

TSRI scientists identify enzyme that maintains healthy periods of inactivity in HSCs to prevent anemia

Stem cells can generate any type of cell in the body, but they are inactive most of the time—and for good reason. When stem cells become too active and divide too often, they risk acquiring cell damage and mutations. In the case of blood stem cells (also called hematopoietic stem cells or HSCs), this can lead to blood cancers, a loss of blood cells and an impaired ability to fight disease.

26 Mar 2015

ItpkB enzyme regulates stem cells function to prevent cancer, anemia

Stem cells can generate any type of cell in the body, but they are inactive most of the time--and for good reason. When stem cells become too active and divide too often, they risk acquiring cell damage and mutations.

24 Mar 2015

MRI more accurate, safe and less painful than liver biopsy in measuring total body iron balance

Investigators at The Saban Research Institute of Children's Hospital Los Angeles have demonstrated that MR imaging of the liver is more accurate than liver biopsy in determining total body iron balance in patients with sickle cell disease and other disorders requiring blood transfusion therapy.

20 Mar 2015

New bone marrow transplant unit launched in Bangalore, India

A bone marrow transplant can mean the difference between life and death for people with blood cancers and related disorders. But many patients in India can't afford the high treatment costs, and for them a transplant is not an option. This is changing thanks to a newly launched bone marrow transplant unit at M.S. Ramaiah Medical College in Bangalore.

19 Mar 2015

New research finds old blood just as good as fresh blood

Just like milk and many other foods, blood used for transfusions is perishable. But contrary to popular belief, new research shows that blood stored for three weeks is just as good as fresh blood - findings published today in the New England Journal of Medicine.

18 Mar 2015

Ludwig researchers establish proof of concept for new approach to drug design

Exploring the fundamental mechanism by which a cell-surface receptor transmits its signal, an international team of Ludwig researchers and their colleagues has established proof of concept for an entirely new approach to drug design. They report that a class of synthetic molecules known as diabodies can, from outside the cell, latch onto a target receptor and manipulate it in such a manner as to induce distinct and varying effects within cells and tissues.

17 Mar 2015

Metabolic derangement may facilitate cell proliferation in PAH

An enzyme that facilitates modification of proteins via a glucose metabolism pathway may promote cell proliferation in the lung tissue of patients with idiopathic pulmonary arterial hypertension, say researchers.

13 Mar 2015

Clinical trial examines uncertainty about when to give blood transfusions after cardiac surgery

New research has shown that patients having heart surgery do not benefit if doctors wait until a patient has become substantially anaemic before giving a transfusion.

12 Mar 2015

Researchers gain new insights into molecular mechanisms affected by weight gain

Until now there have been few molecular epidemiological studies regarding the effects of weight changes on metabolism in the general population. In a recent study conducted and funded within the framework of the Competence Network Obesity, researchers at the Institute of Epidemiology II at Helmholtz Zentrum München evaluated molecular data of the KORA study.

12 Mar 2015

Researchers use stem cells from sickle cell disease patients to grow mature red blood cells

Researchers at Johns Hopkins have successfully corrected a genetic error in stem cells from patients with sickle cell disease, and then used those cells to grow mature red blood cells, they report. The study represents an important step toward more effectively treating certain patients with sickle cell disease who need frequent blood transfusions and currently have few options.

10 Mar 2015

Blood group O provides protection against severe malaria

It has long been known that people with blood type O are protected from dying of severe malaria. In a study published in Nature Medicine, a team of Scandinavian scientists explains the mechanisms behind the protection that blood type O provides, and suggest that the selective pressure imposed by malaria may contribute to the variable global distribution of ABO blood groups in the human population.

10 Mar 2015

Pacritinib for myelofibrosis meets primary endpoint in Phase 3 PERSIST-1 trial

CTI BioPharma Corp. and Baxter International Inc. today announced positive top-line results for the primary endpoint from PERSIST-1, the randomized, controlled Phase 3 registration clinical trial examining pacritinib, a next generation oral JAK2/FLT3 multikinase inhibitor, for the treatment of patients with primary or secondary myelofibrosis.

From Baxter International Inc. 9 Mar 2015

Investigational drug may attack cause of vaso-occlusion crises in sickle cell anemia

Treatment for painful episodes of blood vessel obstruction in sickle cell anemia is currently limited to controlling pain, but an investigational therapy might be able to interfere with the underlying cause of these events, known as vaso-occlusion crises, researchers at Duke Medicine report.

3 Mar 2015

Blood tests in heart surgery patients can lead to anemia, blood transfusions

Laboratory testing among patients undergoing cardiac surgery can lead to excessive bloodletting, which can increase the risk of developing hospital-acquired anemia and the need for blood transfusion, according to an article in the March 2015 issue of The Annals of Thoracic Surgery.

2 Mar 2015

Metrohm USA announces 2015 Young Chemist Award winner

Metrohm USA and Metrohm Canada are pleased to announce the winner of the 2015 Young Chemist Award, Chad Atkins. Chad is completing his Ph.D. at the University of British Columbia where he works under the supervision of Robin Turner and Michael Blades.

26 Feb 2015

Frailty assessment test can accurately predict complications after major operation

Frailty has been used to predict how well a patient may recover from a major operation. Because frailty assessments are not routinely utilized in busy surgical practices, surgeons at Emory University School of Medicine in Atlanta have discovered that a short, approximately one-minute assessment can accurately determine how likely a patient is to have complications after an operation.

26 Feb 2015

Researchers reveal how malaria parasite deploys genetic trickery to escape immune system attack

Up to one million people -- mainly pregnant woman and young children -- are killed each year by the Plasmodium falciparum parasite, which causes the most devastating form of human malaria.

26 Feb 2015

Study compares two different methods of blood transfusion in trauma care

The University of Maryland School of Medicine is part of a new nationwide, multi-site study that may help save hundreds of lives among trauma patients with major bleeding. The study, which was published earlier this month in JAMA, compared two different methods of blood transfusion, and found that one approach gave patients a significantly better chance of survival within the first 24 hours.

20 Feb 2015

UT Southwestern researchers find that acetate speeds up growth and metastasis of tumors

UT Southwestern Medical Center researchers seeking novel ways to combat cancer found that giving acetate, a major compound produced in the gut by host bacteria, to mice sped up the growth and metastasis of tumors.

18 Feb 2015

Red Blood Cells News and Research

Patients with sickle cell disease have sleep disordered breathing problem

TSRI scientists identify enzyme that maintains healthy periods of inactivity in HSCs to prevent anemia

ItpkB enzyme regulates stem cells function to prevent cancer, anemia

MRI more accurate, safe and less painful than liver biopsy in measuring total body iron balance

New bone marrow transplant unit launched in Bangalore, India

New research finds old blood just as good as fresh blood

Ludwig researchers establish proof of concept for new approach to drug design

Metabolic derangement may facilitate cell proliferation in PAH

Clinical trial examines uncertainty about when to give blood transfusions after cardiac surgery

Researchers gain new insights into molecular mechanisms affected by weight gain

Researchers use stem cells from sickle cell disease patients to grow mature red blood cells

Blood group O provides protection against severe malaria

Pacritinib for myelofibrosis meets primary endpoint in Phase 3 PERSIST-1 trial

Investigational drug may attack cause of vaso-occlusion crises in sickle cell anemia

Blood tests in heart surgery patients can lead to anemia, blood transfusions

Metrohm USA announces 2015 Young Chemist Award winner

Frailty assessment test can accurately predict complications after major operation

Researchers reveal how malaria parasite deploys genetic trickery to escape immune system attack

Study compares two different methods of blood transfusion in trauma care

UT Southwestern researchers find that acetate speeds up growth and metastasis of tumors

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