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Researchers compare transcriptomic and cytokine responses of colorectal cancer cells

Oncotarget published "Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal cancer cells" which reported that there was an increase in IL-8 by oxaliplatin and increase in ferritin by cisplatin which may contribute to cancer cell survival.

29 Sep 2021

Research provides the basis for an additional novel immunotherapy for multiple myeloma patients

Oncotarget published "Multipeptide stimulated PBMCs generate TEM/TCM for adoptive cell therapy in multiple myeloma" which reported that Multiple Myeloma patients suffer disease relapse due to the development of therapeutic resistance. Increasing evidence suggests that immunotherapeutic strategies can provide durable responses.

29 Sep 2021

Scientists turn into molecular detectives to find clues to why certain cancer therapies stop working

A new research study at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) turns cancer scientists into molecular detectives, searching for clues for why certain cancers are able to spread and evolve by studying tissues collected within hours of death.

29 Sep 2021

Study reports on ex vivo drug delivery system for delivering MSCs to kidney disease patients

Scientists are reporting promising results in the early stages of a clinical trial designed to gauge the feasibility of a new type of treatment for people with acute kidney disease.

28 Sep 2021

Novel mind-body intervention found to be highly beneficial for treating chronic back pain

Chronic back pain is the leading cause of disability worldwide. In the United States, patients spend up to $300 billion each year to treat the condition, according to a 2012 study published in the Journal of Pain.

28 Sep 2021

Supercoiling and looping can transmit mechanical stress along the DNA backbone, research shows

When people think of DNA, they visualize a string-like double helix structure. In reality, the DNA double helix in cells is supercoiled and constrained into loops. This supercoiling and looping are known to influence every aspect of DNA activity, but how this happens has not been clear.

28 Sep 2021

Primary sclerosing cholangitis: Therapy with synthetic bile acid acts directly on the immune system

Primary Sclerosing Cholangitis (PSC) is a rare, chronic inflammatory disease of the bile ducts and is difficult to treat. Studies conducted by the Division of Gastroenterology and Hepatology at MedUni Wien under the guidance of Michael Trauner (Department of Internal Medicine III) were able to show positive effects from the administration of synthetically produced bile acids and bile acid receptor agonists.

28 Sep 2021

Novel polyclonal antibody therapy meets the criteria for graduation to phase 3 in ACTIV-2 trial

The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, which recently expanded its focus to include evaluating outpatient treatment for COVID-19, today announced that SAB-185, a novel polyclonal antibody therapy, has demonstrated safety and efficacy in phase 2 that meet the criteria for graduation to phase 3 in the ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial (ACTG A5401).

28 Sep 2021

Breast radiation after lumpectomy decreases incidence of ipsilateral breast recurrence for 'low risk' DCIS

A long-term follow up analysis of the NRG-RTOG 9804 randomized trial has shown that breast radiation following lumpectomy significantly reduces incidence of ipsilateral breast recurrence (IBR) for "low risk" DCIS.

27 Sep 2021

Nemours receives NIH grant to foster COVID-19 vaccine uptake among children in Black and Latino communities

Researchers at Nemours Children's Hospital, Delaware, as part of a public-private partnership, have received a National Institutes of Health grant supplement through the Delaware Clinical and Translational Research ACCEL Program to develop and test an approach to foster uptake of the COVID-19 vaccine among children in Black and Latino communities.

27 Sep 2021

Scientists discover novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia

A new type of targeting chaperon protein HSP70 inhibitor QL47 was recently discovered by a team led by Prof. LIU Qingsong from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences to treat FLT3-ITD-positive acute myeloid leukemia (AML).

27 Sep 2021

Monoclonal antibodies may reduce hospital stay, but not mortality in COVID-19

A new study explores the real-world efficacy of monoclonal antibodies against COVID-19 in averting severe disease.

27 Sep 2021

Chronic COVID-19 and divergent variants of SARS-CoV-2

A new study discusses the isolation of two variants of concern (VOCs) from an immunocompromised COVID-19 patient.

27 Sep 2021

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

A new review article investigates the clinical and viral characteristics, pathogenesis, as well as human genetic basis associated with COVID-19.

27 Sep 2021

New blood test to diagnose Alzheimer's disease using atomic force microscopy

If the suspicion of Alzheimer's disease creeps up, those affected must prepare themselves for lengthy and complex procedures until the case is clear.

27 Sep 2021

B cell activating anti-CD73 antibody for the immunotherapy of COVID-19

Despite the advent of numerous vaccines and the discovery of passive monoclonal antibodies for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), there remains an urgent need for definitive therapies for coronavirus disease-2019 (COVID-19) patients.

27 Sep 2021

WHO urges to address the high price and limited production of antibody combination for COVID-19

The World Health Organization (WHO) welcomes the addition of another therapeutic to the world's arsenal against COVID-19, but urges producing companies and governments to address the high price and limited production of the Regeneron antibody combination and ensure safe and appropriate handling of the medicine.

27 Sep 2021

Therapy News and Research

Researchers compare transcriptomic and cytokine responses of colorectal cancer cells

Research provides the basis for an additional novel immunotherapy for multiple myeloma patients

Scientists turn into molecular detectives to find clues to why certain cancer therapies stop working

Study reports on ex vivo drug delivery system for delivering MSCs to kidney disease patients

Novel mind-body intervention found to be highly beneficial for treating chronic back pain

Supercoiling and looping can transmit mechanical stress along the DNA backbone, research shows

Primary sclerosing cholangitis: Therapy with synthetic bile acid acts directly on the immune system

Novel polyclonal antibody therapy meets the criteria for graduation to phase 3 in ACTIV-2 trial

Breast radiation after lumpectomy decreases incidence of ipsilateral breast recurrence for 'low risk' DCIS

Nemours receives NIH grant to foster COVID-19 vaccine uptake among children in Black and Latino communities

Scientists discover novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia

Monoclonal antibodies may reduce hospital stay, but not mortality in COVID-19

Chronic COVID-19 and divergent variants of SARS-CoV-2

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

New blood test to diagnose Alzheimer's disease using atomic force microscopy

B cell activating anti-CD73 antibody for the immunotherapy of COVID-19

WHO urges to address the high price and limited production of antibody combination for COVID-19

Study to determine the characteristics and outcome of patients hospitalized with COVID-19

Diminished waveforms on EKGs of hospitalized patients can help predict worsening health, death

Study quantifies the impact of COVID-19, workplace wellness and long shifts on nurses' health

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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