Liver News and Research

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Blueberry powder may control triple negative breast cancer

In several studies recently conducted at the Beckman Research Institute at the City of Hope, Duarte, CA researchers found that feeding blueberry powder to mice significantly reduced the growth and spread of triple negative breast cancer cells, a very aggressive form of cancer.

1 Oct 2011

New analyses from Phase III studies of VICTRELIS to be presented at AASLD 2011

Merck, known as MSD outside of the United States and Canada, announced today that several new analyses from Phase III studies of VICTRELIS (boceprevir), the company's first-in-class, oral hepatitis C virus NS3/4A protease inhibitor will be presented at the 62nd Annual Meeting of the American Association for the Study of Liver Diseases.

1 Oct 2011

CoreValve prosthesis shows promise against severe aortic stenosis

Among individuals 65 years and older, as many as 30 percent have aortic valve sclerosis or stenosis and as a result of their deteriorating health, cannot enjoy a normal lifestyle. "The aortic valve is a gatekeeper," says Marco Costa, MD, of University Hospitals (UH) Case Medical in Cleveland.

From Medtronic 1 Oct 2011

Vertex announces abstracts from hepatitis C program to be presented at The Liver Meeting

Vertex Pharmaceuticals Incorporated today announced that abstracts from its hepatitis C program, including two late-breaking posters from studies of INCIVEK (telaprevir) tablets and VX-222, were accepted for presentation at The Liver Meeting, the 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) in San Francisco, November 4-8, 2011.

1 Oct 2011

Researchers discover new inherited disorder that causes mental retardation, liver dysfunction

Researchers at the Swedish medical university Karolinska Institutet have discovered a new inherited disorder that causes severe mental retardation and liver dysfunction. The disease, adenosine kinase deficiency, is caused by mutations in the ADK gene, which codes for the enzyme adenosine kinase.

1 Oct 2011

New targeting approach to develop an active site-directed, drug-like PTP1B inhibitor

The work of a team of scientists at Cold Spring Harbor Laboratory (CSHL) led by Professor Nicholas Tonks FRS, suggests a way to overcome one of the major technical obstacles preventing a leading therapeutic target for diabetes and obesity from being addressed successfully by novel drugs.

30 Sep 2011

Estradiol plays an important role in several metabolic diseases

Hormone researchers at the University of Houston (UH) have their sights set on providing long-term treatment options for diabetes, obesity and cardiovascular diseases by better understanding estradiol, the most potent naturally occurring estrogen.

30 Sep 2011

UCLA researchers develop risk scoring system to gauge risk of re-transplantation failure

Liver re-transplantation generally has an inferior outcome compared with a patient's first transplant, due to the technical demands of the surgery and because patients are often sicker than they were at the time of their first procedure.

30 Sep 2011

Galectin posts new corporate video on galectin-inhibiting therapeutics to treat fibrosis and cancer

Galectin Therapeutics Inc. today announced that it posted a new corporate presentation video to its website, www.galectintherapeutics.com, that highlights the Company's leadership position in developing galectin-inhibiting therapeutics to treat fibrosis and cancer.

30 Sep 2011

Tobacco companies deliberately kept findings of cancer-causing radioactive particles from the public

Tobacco companies knew that cigarette smoke contained radioactive alpha particles for more than four decades and developed "deep and intimate" knowledge of these particles' cancer-causing potential, but they deliberately kept their findings from the public, according to a new study by UCLA researchers.

29 Sep 2011

Researchers identify 'programmed cell death' pathway in parasitic worms

Researchers from the Walter and Eliza Hall Institute have for the first time identified a 'programmed cell death' pathway in parasitic worms that could one day lead to new treatments for one of the world's most serious and prevalent diseases.

29 Sep 2011

FOX06 protein contributes to liver overproduction of glucose in diabetes

Researchers at the John G. Rangos Sr. Research Center at Children's Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine have identified a powerful molecular pathway that regulates the liver's management of insulin and new glucose production, which could lead to new therapies for diabetes.

29 Sep 2011

AASLD publishes updated practice guidelines on hepatitis C

On Monday, September 26, 2011, the American Association for the Study of Liver Diseases published online at its journal Hepatology's website an update to its practice guidelines for hepatitis C – "An Update on Treatment of Genotype 1 Chronic Hepatitis C Virus Infection: 2011 Practice Guideline by the American Association for the Study of Liver Diseases."

29 Sep 2011

High volume liver transplant centers achieve better risk-adjusted survival rates

The shortage of available organs for transplantation has driven up use of high-risk donor livers. New research published in the October issue of Liver Transplantation, a journal of the American Association for the Study of Liver Diseases, reported that high volume transplant centers more frequently utilized livers with a high donor risk index, but achieved better risk-adjusted graft and recipient survival rates compared with lower volume centers.

29 Sep 2011

Long-term morbidity and mortality of NAFLD patients with advanced fibrosis, cirrhosis

Patients with non-alcoholic fatty liver disease (NAFLD) with advanced fibrosis or cirrhosis have a lower incidence of liver-related complications and hepatocellular carcinoma (HCC) than patients infected with hepatitis C virus (HCV), according to the prospective study published in the October issue of Hepatology, a journal of the American Association for the Study of Liver Diseases.

28 Sep 2011

Liver transplantation candidates without HCC derive greater survival benefit from LDLT

New research shows liver transplantation candidates without hepatocellular carcinoma (HCC) derive a greater survival benefit from a living donor liver transplant (LDLT) than waiting for a deceased donor liver transplant.

28 Sep 2011

New York Times 'Small Fixes' section examines multiple low-cost interventions for global health problems

The New York Times on Monday published a special section, titled "Small Fixes," containing several articles examining how low-cost innovations could help save thousands of lives.

28 Sep 2011

Low vitamin B12 raises risk of dementia in the elderly: Study

According to a latest study the elderly with low levels of vitamin B12 in their blood may be more likely to develop problems with their thinking skills and have more brain shrinkage. The study points to a link between low B12 and early cognitive decline, a condition that often leads to dementia. Previous research has found that those people with high levels of vitamin B12 in their blood have lower levels of an amino acid called homocysteine, which some studies have linked to an increased risk of Alzheimer's disease, memory loss, and stroke.

27 Sep 2011

Raised blood pressure may higher risk of cancer, death

Raised blood pressure is linked to a higher risk of developing cancer or dying from the disease according to the findings of the largest study to date to investigate the association between the two conditions.

27 Sep 2011

Vitamin B12 deficiency linked to cognitive problems or loss in brain volume among older people

Older people with low levels of vitamin B12 in their blood may be more likely to lose brain cells and develop problems with their thinking skills, according to a study published in the September 27, 2011, print issue of Neurology, the medical journal of the American Academy of Neurology.

27 Sep 2011

Liver News and Research

Blueberry powder may control triple negative breast cancer

New analyses from Phase III studies of VICTRELIS to be presented at AASLD 2011

CoreValve prosthesis shows promise against severe aortic stenosis

Vertex announces abstracts from hepatitis C program to be presented at The Liver Meeting

Researchers discover new inherited disorder that causes mental retardation, liver dysfunction

New targeting approach to develop an active site-directed, drug-like PTP1B inhibitor

Estradiol plays an important role in several metabolic diseases

UCLA researchers develop risk scoring system to gauge risk of re-transplantation failure

Galectin posts new corporate video on galectin-inhibiting therapeutics to treat fibrosis and cancer

Tobacco companies deliberately kept findings of cancer-causing radioactive particles from the public

Researchers identify 'programmed cell death' pathway in parasitic worms

FOX06 protein contributes to liver overproduction of glucose in diabetes

AASLD publishes updated practice guidelines on hepatitis C

High volume liver transplant centers achieve better risk-adjusted survival rates

Long-term morbidity and mortality of NAFLD patients with advanced fibrosis, cirrhosis

Liver transplantation candidates without HCC derive greater survival benefit from LDLT

New York Times 'Small Fixes' section examines multiple low-cost interventions for global health problems

Low vitamin B12 raises risk of dementia in the elderly: Study

Raised blood pressure may higher risk of cancer, death

Vitamin B12 deficiency linked to cognitive problems or loss in brain volume among older people

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