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Radioimmunotherapy shows promise for HIV infection and viral cancers

Scientists at Albert Einstein College of Medicine of Yeshiva University have piggybacked antibodies onto radioactive payloads to deliver doses of radiation that selectively target and destroy microbial and HIV-infected cells.

16 Feb 2009

ViroPharma reports results of trial for Maribavir in bone marrow transplant patients

ViroPharma Incorporated has announced that its Phase 3 trial evaluating maribavir used as prophylaxis in allogeneic stem cell, or bone marrow, transplant (SCT) patients did not achieve its primary endpoint.

10 Feb 2009

Adolescents should participate in decisions about end-of-life care

Conversations between adolescents suffering from chronic illnesses and their families about end-of-life wishes well before a serious event occurs won't discourage hope for recovery or cause additional emotional or mental harm to young patients, according to new research from Children's National Medical Center and St. Jude Children's Research Hospital published in the journal Pediatrics.

9 Feb 2009

Anti-HIV vaginal gel shows promise

An investigational vaginal gel intended to prevent HIV infection in women has demonstrated encouraging signs of success in a clinical trial conducted in Africa and the United States.

9 Feb 2009

World experts meet in Australia to find ways to wipe out malaria

Australia is host to a meeting of World health experts which aims to find ways of eradicating malaria, one of the world's most dangerous killer diseases.

9 Feb 2009

Scientists create first crystal structure of an intermediate particle in virus assembly

The structure, described February 8 in an advance online publication of the journal Nature , provides fresh insights into the elegant dance that viral proteins perform to create the infectious structure that causes all manner of misery and disease, say researchers.

8 Feb 2009

Idenix Pharmaceuticals and GSK sign agreement for novel NNRTI for treatment of HIV

Idenix Pharmaceuticals, Inc. and GlaxoSmithKline (GSK) today announced the execution of a license agreement granting GSK exclusive worldwide rights to IDX899.

8 Feb 2009

Sangamo BioSciences starts trial of CCR5-ZFP therapeutic to treat HIV/AIDS

Sangamo BioSciences, Inc. has announced that its collaborators at the University of Pennsylvania have opened a Phase 1 clinical trial to evaluate SB-728-T for the treatment of HIV/AIDS.

5 Feb 2009

Many neglected diseases lacking research funding

The first comprehensive survey of global spending on neglected disease R&D, published in this week's PLoS Medicine , finds that just over $US 2.5 billion was invested into R&D of new products in 2007, with three diseases-HIV/AIDS, TB, and malaria-receiving nearly 80% of the total

5 Feb 2009

Green tea may counteract anticancer effects of cancer therapy, bortezomib (Velcade)

Green tea products have become regarded as a valuable health supplement, as studies have shown evidence of its benefit against a variety of diseases, including cancer.

3 Feb 2009

New understanding of Ebola virus and tetherin protein

Researchers at the University of Pennsylvania School of Medicine have likely found one reason why the Ebola virus is such a powerful, deadly, and effective virus.

29 Jan 2009

New bone cement may prevent amputations

Old technologies, bone cement and a well known antibiotic, may effectively fight an emerging infection in soldiers with compound bone fractures, according to a study published online in the Journal of Orthopedic Research.

29 Jan 2009

Substance use common among patients with tuberculosis

About one in five U.S. tuberculosis patients reports abusing alcohol or using illicit drugs, and those who do appear more contagious and difficult to treat, according to a report in the January 26 issue of Archives of Internal Medicine.

27 Jan 2009

New study sheds light on higher adherence to HIV drugs in Africa than in North America

Levels of near-perfect adherence to life saving antiretroviral drugs among African HIV patients should be understood as a means of preserving key social relationships, says a new study published in the open-access journal PLoS Medicine.

27 Jan 2009

Waging war on tropical diseases may be key to U.S. foreign policy

Stating that neglected tropical diseases (NTDs) not only promote poverty but also destabilize communities, former Health and Human Services Secretary Tommy Thompson and Sabin Vaccine Institute President Peter Hotez call upon the public-health and foreign-policy communities to embrace medical diplomacy and NTD control as a means to combat terrorism in an article published January 27 in the open-access journal PLoS Neglected Tropical Diseases.

27 Jan 2009

STDs disrupt genetic bottleneck that usually constrains HIV infection

Scientists have shown that HIV faces a genetic "bottleneck" when the virus is transmitted heterosexually from one person to another, by way of the genital mucosa.

23 Jan 2009

Roche NimbleGen microarray technology enables highest-resolution map of human genome copy number variation

Roche NimbleGen's CGH microarray platform was used to generate the highest-resolution map of human genome copy number variation.

23 Jan 2009

Topical treatment wipes out herpes with RNAi

Whether condoms or abstinence, most efforts to prevent sexually transmitted diseases have a common logic: keep the pathogen out of your body altogether.

21 Jan 2009

Potential new target in the war on HIV/AIDS

The study revealed that a variant of a protein involved in HIV pathogenesis can suppress production of an HIV protein, known as Nef. Nef is required for the human immunodeficiency virus to develop into AIDS through a series of complex events involving viral elements and cellular proteins. Nef has never been a target for drug treatment in HIV patients.

21 Jan 2009

Too much weight loss can be a bad thing

Doctors are not doing enough to pick up on problems with excessive weight loss, says a Saint Louis University physician who helped draft recent guidelines to diagnose the condition called "cachexia" (kuh-kex-ee-uh).

21 Jan 2009