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Experimental therapy stops glioblastoma, high-grade gliomas in human cells and mouse models

Researchers report in the journal Cancer Cell an experimental therapy that in laboratory tests on human cells and mouse models stops aggressive, treatment-resistant and deadly brain cancers called glioblastoma and high-grade gliomas.

10 May 2016

Research shows spleen MZ B cells produce signaling proteins involved in inflammatory responses

The inability to adequately respond to infection can cause a whole-body state of inflammation known as sepsis. This can eventually lead to systemic inflammatory response syndrome (SIRS), and even death.

9 May 2016

Elevated endothelial progenitor cells may characterise PAH patients

Plasma levels of endothelial progenitor cells are elevated in patients with pulmonary arterial hypertension, say researchers.

7 May 2016

Gene therapy could be potential treatment for neuropathic pain in cancer patients

A study providing new information about neuropathic pain afflicting some 90 percent of cancer patients who have had nerve damage caused by tumors, surgery, chemotherapy or radiation indicates gene therapy as a possible treatment.

6 May 2016

Experimental drug ozanimod moderately effective in treatment of ulcerative colitis

Researchers at University of California San Diego School of Medicine have shown that ozanimod (RPC1063), a novel drug molecule, is moderately effective in the treatment of ulcerative colitis. Results of the Phase II clinical trial will appear in the May 5 issue of the New England Journal of Medicine.

5 May 2016

Real risk of rebound syndrome following fingolimod cessation for MS

Rebound syndrome following cessation of fingolimod for multiple sclerosis occurs at a clinically relevant rate, shows research, prompting the need for further study on how best to sequence and discontinue such drugs.

4 May 2016

Cerebellar not cerebral atrophy predicts poor anti-NMDAR encephalitis outcome

Diffuse cerebral atrophy in patients with anti-N-methyl-D-aspartate receptor encephalitis does not necessarily mean irreversible brain damage, whereas progressive cerebellar atrophy may indicate a poor long-term prognosis, researchers report.

4 May 2016

Combination of existing chemotherapy drugs can reduce breast cancer stem cells, improve survival

Two existing chemotherapy drugs appear to be a powerful pair in targeting errant stem cells that are making breast cancer and enabling its spread and recurrence, scientists report.

3 May 2016

Researchers examine critical role of hypoxia in induction, amplification of FOP lesions

The cellular response to the lack of oxygen fans the flames of flare-ups in a rare bone disorder. In fibrodysplasia ossificans progressiva (FOP), a mutation triggers bone growth in muscles, which limits motion, breathing, and swallowing, among a host of progressive symptoms.

3 May 2016

Brain receptor that initiates adolescent synaptic pruning appears to go awry in autism, schizophrenia

Research led by SUNY Downstate Medical Center has identified a brain receptor that appears to initiate adolescent synaptic pruning, a process believed necessary for learning, but one that appears to go awry in both autism and schizophrenia.

3 May 2016

Study shows cannabinoid type 2 receptor plays vital role in signal processing of the brain

The cannabinoid type 2 receptor - also called "CB2 receptor" - is a special membrane protein. Its function is to receive chemical signals that control cellular activity. "Until now, this receptor was considered part of the immune system without function in nerve cells.

3 May 2016

LJI study could provide important target for autoimmune disease interventions

Follicular helper T cells (Tfh cells), a rare type of T cells, are indispensable for the maturation of antibody-producing B cells. They promote the proliferation of B cells that produce highly selective antibodies against invading pathogens while weeding out those that generate potentially harmful ones.

3 May 2016

New nanoparticle approach can deliver antiobesity drugs directly to fat tissue

Researchers at MIT and Brigham and Women's Hospital have developed nanoparticles that can deliver antiobesity drugs directly to fat tissue. Overweight mice treated with these nanoparticles lost 10 percent of their body weight over 25 days, without showing any negative side effects.

3 May 2016

Snapshots of NMDA receptor activation may help in novel drug design

Structural biologists at Cold Spring Harbor Laboratory and Janelia Research Campus/HHMI, have obtained snapshots of the activation of an important type of brain-cell receptor. Dysfunction of the receptor has been implicated in a range of neurological illnesses, including Alzheimer's disease, Parkinson's disease, depression, seizure, schizophrenia, autism, and injuries related to stroke.

3 May 2016

BioAFM Advancements

In this interview, News Medical talks to Dr. Thomas Mueller of Bruker Nano surface, about the advances in BioAFM.

From Bruker Nano Surfaces and Metrology 3 May 2016

Hsp90 inhibitors could be effective in treating drug-resistant prostate cancers

Men with aggressive prostate cancer that has stopped responding to conventional treatment could potentially benefit from a new class of cancer drug designed to overcome drug resistance, a new study suggests.

2 May 2016

Elusive brain receptor may play vital role in death of neurons from neurological diseases

Strokes, seizures, traumatic brain injury and schizophrenia: these conditions can cause persistent, widespread acidity around neurons in the brain. But exactly how that acidity affects brain function isn't well understood.

30 Apr 2016

Predictive statistical approach opens door to development of more effective therapies for breast cancer

Designing effective new drugs, especially drugs to fight cancer, demands that you know as much as you can about the molecular workings of cancer growth. Without that, it's like planning to fight a war against an enemy you've never seen.

29 Apr 2016

Study helps discover new treatments for type 2 diabetes in men with low testosterone

Doctors have long known that men with low testosterone are at greater risk for developing type 2 diabetes. For the first time, researchers have identified how testosterone helps men regulate blood sugar by triggering key signaling mechanisms in islets, clusters of cells within the pancreas that produce insulin. The findings, co-authored by Tulane University researchers, are published in the journal

29 Apr 2016

New research on EdnrB, Wnt signaling pathways could lead to therapies for skin pigment disorders

A pair of molecular signals controls skin and hair color in mice and humans — and could be targeted by new drugs to treat skin pigment disorders like vitiligo, according to a report by scientists at NYU Langone Medical Center.

29 Apr 2016

Receptor News and Research

Experimental therapy stops glioblastoma, high-grade gliomas in human cells and mouse models

Research shows spleen MZ B cells produce signaling proteins involved in inflammatory responses

Elevated endothelial progenitor cells may characterise PAH patients

Gene therapy could be potential treatment for neuropathic pain in cancer patients

Experimental drug ozanimod moderately effective in treatment of ulcerative colitis

Real risk of rebound syndrome following fingolimod cessation for MS

Cerebellar not cerebral atrophy predicts poor anti-NMDAR encephalitis outcome

Combination of existing chemotherapy drugs can reduce breast cancer stem cells, improve survival

Researchers examine critical role of hypoxia in induction, amplification of FOP lesions

Brain receptor that initiates adolescent synaptic pruning appears to go awry in autism, schizophrenia

Study shows cannabinoid type 2 receptor plays vital role in signal processing of the brain

LJI study could provide important target for autoimmune disease interventions

New nanoparticle approach can deliver antiobesity drugs directly to fat tissue

Snapshots of NMDA receptor activation may help in novel drug design

BioAFM Advancements

Hsp90 inhibitors could be effective in treating drug-resistant prostate cancers

Elusive brain receptor may play vital role in death of neurons from neurological diseases

Predictive statistical approach opens door to development of more effective therapies for breast cancer

Study helps discover new treatments for type 2 diabetes in men with low testosterone

New research on EdnrB, Wnt signaling pathways could lead to therapies for skin pigment disorders

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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