Cell Signaling News and Research

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Cell signaling is vital for cells to communicate and coordinate their activities, not just in the human body, but in all organisms. There are thousands of signaling pathways, ranging from protein homeostasis to carcinogenesis and biofilm formation.

Cell-of-origin for prostate cancer identified

UCLA scientists have identified for the first time a cell-of-origin for human prostate cancer, a discovery that could result in better predictive and diagnostics tools and the development of new and more effective targeted treatments for the disease.

31 Jul 2010

New discovery may lead to effective targeted treatments for prostate cancer: UCLA

30 Jul 2010

Cetuximab recommended for colorectal cancer tumors without mutation in KRAS gene

In a report published in the July 2010 issue of the American Society for Clinical Oncology Post, new recommendations on the use of the drug cetuximab have been issued after officials halted enrollment in a phase III clinical trial in patients with spread of colon cancer into regional lymph nodes whose tumors had been surgically removed.

17 Jul 2010

Penn researchers reverse cognitive decline in fruit flies with Alzheimer's gene mutation

Investigators have found that fruit fly (Drosophila melanogaster) males -- in which the activity of an Alzheimer's disease protein is reduced by 50 percent -- show impairments in learning and memory as they age. What's more, the researchers were able to prevent the age-related deficits by treating the flies with drugs such as lithium, or by genetic manipulations that reduced nerve-cell signaling.

16 Jul 2010

Cigarette smoking affects entire networks of gene interaction: Research

The effects of smoking cigarettes on gene activity have been investigated in the largest study of its kind. Researchers writing in the open access journal BMC Medical Genomics studied white blood cells taken from 1,240 people to identify 323 unique genes whose expression levels were significantly correlated with smoking behavior.

15 Jul 2010

NanoString Technologies increases throughput of nCounter Analysis System

NanoString Technologies, Inc., a privately held life sciences company marketing a novel digital molecular barcoding technology for detecting and counting large sets of targets in biological samples, today announced that it has increased the throughput of its nCounter Analysis System by expanding its multiplexing capacity to 800 gene transcripts per reaction.

From NanoString Technologies 15 Jul 2010

Researchers develop computer program to accurately simulate protein folding

All proteins self-assemble in a fraction of the blink of an eye, but it can take a long time to mimic the process. And there has been no guarantee of success, even with the most powerful computers - until now.

8 Jul 2010

Fluidigm's IFC platform products help perform digital-PCR measurements on single gene

Utilizing Fluidigm Corporation's Dynamic Array™ and Digital Array™ integrated fluidic circuits (IFCs), Stanford University researchers to have discovered a much larger spectrum of differences between individual cells than has previously been demonstrated. Among these differences are the communication capabilities that emerge from the interactions of genetic circuitry that mediates cell-to-cell communication.

2 Jul 2010

PIKAMAB secures exclusive rights to issued U.S. patent from UABRF

PIKAMAB, a biopharmaceutical company specializing in stratified medicine, announced today that it has secured exclusive rights to an issued U.S. patent (US 6,986,987) from the UAB Research Foundation. This patent pertains to the discovery that the functional polymorphism (Ser/Gly248) in the cytoplasmic domain of Fc alpha receptor determines the proinflammatory potential of serum IgA autoantibodies through cell signaling and production of cytokines such as TNF-alpha, IL-6, and IL-1β in an allele-dependent manner.

1 Jul 2010

Individual cells react differently to complex signals: Study

Using new technology that allows scientists to monitor how individual cells react in the complex system of cell signaling, Stanford University researchers have uncovered a much larger spectrum of differences between each cell than ever seen before.

29 Jun 2010

Engineered allosteric regulation provides precise control of kinase activity in living cells

Cancer occurs when human cells move and multiply inappropriately. Within cells, a process called phosphorylation serves as an on/off switch for a number of cellular processes that can be involved in cancer, including metabolism, transcription, configuration, movement, cell death and differentiation. This process is controlled by a group of enzymes called protein kinases that - working together and separately - modify the structure of proteins, changing them and allowing them to control cellular processes.

28 Jun 2010

UH researchers analyze 'wireless connections' in brain to prevent neurological diseases

Many diseases of brain function, such as epilepsy and schizophrenia, are caused by problems in how neurons communicate with each other. A University of Houston researcher and his team are analyzing these commands and connections in an attempt to prevent those diseases.

25 Jun 2010

Baylor University researchers awarded grant to research and test new compounds for cancer

The National Institutes of Health has awarded two Baylor University researchers a $1.46 million grant to research and test new compounds that could help fight cancerous tumors.

18 Jun 2010

Possible mechanism identified for how lithium treats bipolar disorder

Lithium has been established for more than 50 years as one of the most effective treatments for manic depression, clinically termed bipolar disorder. However, scientists have never been entirely sure exactly why it is beneficial.

18 Jun 2010

Biological mechanism associated with remission during pregnancy

During pregnancy, many women experience remission of autoimmune diseases like multiple sclerosis and uveitis. Now, scientists have described a biological mechanism responsible for changes in the immune system that helps to explain the remission.

17 Jun 2010

BD Biosciences further expands Research Grant program to support promising stem cell research

BD Biosciences, a segment of BD, announced today a further expansion of its Research Grant program, adding $100,000 worth of reagents, cell culture tools and labware to support promising stem cell research.

From BD (Becton, Dickinson and Company) 17 Jun 2010

Stress-related psychiatric disorders more common among women: Study

There may be a biological reason why depression and other stress-related psychiatric disorders are more common among women compared to men. Studying stress signaling systems in animal brains, neuroscience researchers found that females are more sensitive to low levels of an important stress hormone and less able to adapt to high levels than males.

16 Jun 2010

Clinical trial to examine use of biomarkers to advance treatment of malignant gliomas launched

The Brain Tumor Unit at the Moores UCSD Cancer Center at the University of California, San Diego in La Jolla, is launching a clinical trial that will examine the use of biomarkers to advance the treatment of malignant gliomas, brain tumors that start in the brain or spinal cord tissue. Annually, about 17,000 Americans are diagnosed with gliomas, which are difficult to treat and often fatal.

16 Jun 2010

Depression and other stress-related psychiatric disorders in women may have biological basis: Research

15 Jun 2010

Pediatric oncologist describes current state of science in combating neuroblastoma

Pediatric oncologist John M. Maris, M.D., describes the current state of the science in combating neuroblastoma, the most common solid cancer of early childhood. In his article in the June 10, 2010 New England Journal of Medicine, "Recent Advances in Neuroblastoma," Maris reviews the field's latest research knowledge—much of it based on efforts by Maris and his colleagues at The Children's Hospital of Philadelphia.

15 Jun 2010

Cell Signaling News and Research

Further Reading

Cell-of-origin for prostate cancer identified

New discovery may lead to effective targeted treatments for prostate cancer: UCLA

Cetuximab recommended for colorectal cancer tumors without mutation in KRAS gene

Penn researchers reverse cognitive decline in fruit flies with Alzheimer's gene mutation

Cigarette smoking affects entire networks of gene interaction: Research

NanoString Technologies increases throughput of nCounter Analysis System

Researchers develop computer program to accurately simulate protein folding

Fluidigm's IFC platform products help perform digital-PCR measurements on single gene

PIKAMAB secures exclusive rights to issued U.S. patent from UABRF

Individual cells react differently to complex signals: Study

Engineered allosteric regulation provides precise control of kinase activity in living cells

UH researchers analyze 'wireless connections' in brain to prevent neurological diseases

Baylor University researchers awarded grant to research and test new compounds for cancer

Possible mechanism identified for how lithium treats bipolar disorder

Biological mechanism associated with remission during pregnancy

BD Biosciences further expands Research Grant program to support promising stem cell research

Stress-related psychiatric disorders more common among women: Study

Clinical trial to examine use of biomarkers to advance treatment of malignant gliomas launched

Depression and other stress-related psychiatric disorders in women may have biological basis: Research

Pediatric oncologist describes current state of science in combating neuroblastoma

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

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