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Removal of a critical enzyme may help cases of sepsis finds research

Scientists at the University of California San Diego School of Medicine have shown that removal of an enzyme called the PH domain Leucine-rich repeat Protein Phosphatase 1 (PHLPP1) could help laboratory mice with sepsis in a model they had created for their experiment. The study titled, “PHLPP1 counter-regulates STAT1-mediated inflammatory signalling,” was published this week in the journal eLife.

15 Aug 2019

Chlamydia vaccine shows promise after a successful clinical trial

A vaccine against the sexually transmitted infection (STI) chlamydia is now a substantial step closer to reality after successfully passing its Phase 1 clinical trial.

14 Aug 2019

Bile pigment may play an unexpected role in protecting the brain

In studies in mice, Johns Hopkins Medicine researchers report they have found that bilirubin, a bile pigment most commonly known for yellowing the skin of people with jaundice, may play an unexpected role in protecting brain cells from damage from oxidative stress.

From Johns Hopkins Medicine 13 Aug 2019

NIH-funded clinical trial will evaluate seasonal influenza vaccines with two experimental adjuvants

An early-stage clinical trial is evaluating two licensed seasonal influenza vaccines, administered with or without novel adjuvants, for their safety and ability to generate an immune response.

9 Aug 2019

Longer-lived, but less toxic drug may work better for pancreatic cancer

Unlike many other cancers, most pancreatic tumors are rock hard.

9 Aug 2019

ISCT expresses concern about companies offering unproven T-cell preservation services

ISCT, the International Society for Cell and Gene Therapy, the global professional society of clinicians, researchers, regulatory specialists, technologists and industry partners in the cell and gene therapy sector, today announces its objection to linking the benefits of cellular immunotherapy, in particular Chimeric Antigen Receptor (CAR) T-cell therapy, with recent market offerings for third party cryopreserving and banking of T-cells for future therapeutic use.

8 Aug 2019

New improved model for cancer wasting syndrome cachexia

A new model of cancer-related cachexia promises to help scientists understand why patients with cancer show severe wasting, which in turn may drive the development of better therapies.

7 Aug 2019

Pitt researchers first to grow genetically modified miniature human livers in the lab

Researchers at the University of Pittsburgh School of Medicine are the first to grow genetically modified miniature human livers in the laboratory, to emulate human liver disease progression and test therapeutics.

7 Aug 2019

New mouse model could lead to a better understanding of cachexia syndrome

A study published in Cell Reports Aug. 6 describes the generation of a new mouse model developed at Hollings Cancer Center that could lead to a better understanding of the cachexia syndrome. This wasting condition, characterized by excessive weight loss, has one of the highest incidences in pancreatic cancer patients.

6 Aug 2019

FDA announces new policy framework for development of regenerative medicine products

Today the U.S. Food and Drug Administration announced a comprehensive policy framework for the development and oversight of regenerative medicine products, including novel cellular therapies.

5 Aug 2019

New staffing model based on team approach for specialist palliative care

The Canadian Society of Palliative Care Physicians has developed a new staffing model for specialist palliative care teams that can deliver an optimal, integrated palliative care program.

1 Aug 2019

Mice brain study reveals secrets about Alzheimer’s

Researchers from University of California, Irvine have found the key responses of brain cells to Alzheimer’s disease (AD) and say that this could help them understand the chronic debilitating and progressive neurodegenerative disease better in future.

1 Aug 2019

Scientists gain insights into how the brain perceives different odors

Scientists have looked deep into the brain to understand the relationships between the synapses of olfactory nerves and the functions of inhibitory interneurons.

31 Jul 2019

Johns Hopkins researchers use nanotechnology to repair faulty brain circuits

Working with mouse and human tissue, Johns Hopkins Medicine researchers report new evidence that a protein pumped out of some — but not all — populations of “helper” cells in the brain, called astrocytes, plays a specific role in directing the formation of connections among neurons needed for learning and forming new memories.

31 Jul 2019

New gene-editing study finds protective genes against Zika virus

Tel Aviv scientists have discovered certain genes that protect the host organism against attack by Zika virus, raising hopes of an eventual vaccine or cure for this dreaded viral disease.

28 Jul 2019

Gut bacteria that prevents mice from becoming obese may also control weight in people

Researchers at University of Utah Health have identified a specific class of bacteria from the gut that prevents mice from becoming obese, suggesting these same microbes may similarly control weight in people.

26 Jul 2019

UC Davis researchers identify how diabetes increases risk of vascular diseases

A team of UC Davis Health scientists and physicians has identified a cellular connection between diabetes and one of its major complications - blood vessel narrowing that increases risks of several serious health conditions, including heart disease and stroke.

25 Jul 2019

Novel therapeutic strategy for treating Lafora Disease shows promise in preclinical study

A team of scientists have designed and tested in mice a novel and promising therapeutic strategy for treating Lafora Disease, a fatal form of childhood epilepsy.

25 Jul 2019

CAR-T cells used to target glioblastoma

Immunotherapy is the new weapon against cancers and building upon existing research, a team of researchers from the Massachusetts General Hospital have devised a way to make immunotherapy more effective in a deadly and common form of brain cancer called glioblastoma.

24 Jul 2019