Necrosis News and Research

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Specific inflammatory pattern found in patients with pneumonia and COPD

Patients with community-acquired pneumonia on a background of chronic obstructive pulmonary disease have a different early inflammatory pattern than patients with CAP only, a prospective study shows.

30 Apr 2013

Continuous monitoring flags acute compartment syndrome

Continuous intracompartmental pressure monitoring is highly accurate for the detection of acute compartment syndrome after tibial diaphyseal fracture, say UK researchers who believe it may allow diagnosis before signs and symptoms occur.

29 Apr 2013

Specific inflammatory pattern found in patients with pneumonia and COPD

Patients with community-acquired pneumonia on a background of chronic obstructive pulmonary disease have a different early inflammatory pattern than patients with CAP only, a prospective study shows.

29 Apr 2013

Childhood bacterial meningitis influences educational, financial achievement

Research suggests that children who become infected with bacterial meningitis have a lower educational achievement and are less likely to be economically self-sufficient in adulthood than those who do not.

25 Apr 2013

Hospital for Special Surgery receives grant for new genomics center to study autoimmune diseases

Hospital for Special Surgery in New York City has received a $5.6 million grant from The Tow Foundation to establish the Hospital for Special Surgery Genomics Center.

25 Apr 2013

Study: Use of anti-TNF therapies in RA patients does not increase risk of herpes zoster

Patients with rheumatoid arthritis (RA) who initiated use of anti-tumor necrosis factor therapies were not at a higher risk of developing herpes zoster (shingles), compared with patients who initiated nonbiologic treatment regimens, according to research from the University of Alabama at Birmingham (UAB) and the Oregon Health and Science University. The findings appeared in the March 6, 2013, issue of the Journal of the American Medical Association (JAMA).

22 Apr 2013

Study: Women with RA exposed to anti-tumor necrosis drugs may have increased abortion rates

A new study published in the American College of Rheumatology (ACR) journal, Arthritis Care & Research, reveals that women with rheumatoid arthritis (RA) who were on methotrexate (MTX), a drug commonly used to reduce inflammation caused by RA, had lower rates of induced abortions compared to women with RA who were not exposed to the medication.

16 Apr 2013

Researchers unravel dual role of tumor necrosis factor in TB

Tumor necrosis factor - normally an infection-fighting substance produced by the body- can actually heighten susceptibility to tuberculosis if its levels are too high.

12 Apr 2013

Same factor that helps fight off severe inflammatory ailments also functions as enemy

The same factor in our immune system that is instrumental in enabling us to fight off severe and dangerous inflammatory ailments is also a player in doing the opposite at a later stage, causing the suppression of our immune response.

4 Apr 2013

Ulcerative colitis and Crohn’s disease treatments: an interview with Dr Parikh, vice president, general medicine, Takeda

Ulcerative colitis (UC) and Crohn’s disease (CD) are both relapsing and remitting chronic diseases of bowel inflammation. By that I mean they flare and physicians try to get the flare under control and try to induce remission. However, despite a number of treatments available, they tend to relapse.

From Takeda 3 Apr 2013

Cytori receives patent for methods of treating renal diseases using ADRCs

Cytori Therapeutics received US Patent No. 8,404,229 (the '229 patent) for methods of treating renal diseases using adipose-derived regenerative cells (ADRCs).

30 Mar 2013

Japan's MHLW approves XELJANZ for treatment of adults with rheumatoid arthritis

Pfizer Inc. announced today that the Japanese Ministry of Health, Labor and Welfare has approved XELJANZ (tofacitinib citrate) for the treatment of adults with rheumatoid arthritis who have had an inadequate response to existing therapies.

25 Mar 2013

Male circumcision a 'staggeringly under-utilized tool'

"PrePex, the new nonsurgical circumcision tool experts believe could revolutionize the prevention of HIV and AIDS in sub-Saharan Africa, is easier to assemble than a toy you might find in a Happy Meal," freelance journalist Patrick Adams writes in the New York Times' "Opinionator" blog.

22 Mar 2013

New study may help develop targeted therapies for controlling tissue destruction

Stroke, heart attacks and numerous other common disorders result in a massive destruction of cells and tissues called necrosis. It's a violent event: As each cell dies, its membrane ruptures, releasing substances that trigger inflammation, which in turn can cause more cellular necrosis.

19 Mar 2013

Cytomegalovirus employs a novel trick to hide from immune detection

A virus that most people have probably never heard of, yet most of us carry, is the number 1 infectious cause of congenital birth defects. One in 750 children are born with, or develop, permanent disabilities such as hearing loss or brain damage as a result of CMV (cytomegalovirus) infection in the womb.

17 Mar 2013

Research finding aids efforts toward cytomegalovirus vaccine

A virus most people probably have never heard of, but that the majority of us carry, is the No. 1 infectious cause of congenital birth defects in the U.S. today. Because of cytomegalovirus (CMV) infection during in utero development, 1 in 750 children are born with or develop permanent disabilities such as hearing loss or brain damage.

14 Mar 2013

Medication use and doctor visits drive up jaw necrosis-related costs

Long-term medication use and follow-up visits are the main drivers affecting costs associated with cancer-related bisphosphonate-associated osteonecrosis of the jaw, report researchers in Oral Diseases.

8 Mar 2013

Inflammatory marker for schizophrenia treatment resistance, severity

Levels of the inflammatory marker soluble tumor necrosis factor receptor 1 may be associated with severity of symptoms and treatment resistance in schizophrenia, say Brazilian scientists.

8 Mar 2013

RA patients who initiate anti-TNF therapies do not have higher risk of shingles: Study

Although patients with rheumatoid arthritis have a disproportionately higher incidence of herpes zoster (shingles), an analysis that included nearly 60,000 patients with RA and other inflammatory diseases found that those who initiated anti-tumor necrosis factor therapies were not at higher risk of herpes zoster compared with patients who initiated nonbiologic treatment regimens, according to a study appearing in the March 6 issue of JAMA.

7 Mar 2013

Eye-rubbing may provoke, aggravate keratoconus

Rubbing the eyes leads to an increase in protease activity and levels of protease and inflammatory mediators, a clinical study shows.

1 Mar 2013

Necrosis News and Research

Specific inflammatory pattern found in patients with pneumonia and COPD

Continuous monitoring flags acute compartment syndrome

Specific inflammatory pattern found in patients with pneumonia and COPD

Childhood bacterial meningitis influences educational, financial achievement

Hospital for Special Surgery receives grant for new genomics center to study autoimmune diseases

Study: Use of anti-TNF therapies in RA patients does not increase risk of herpes zoster

Study: Women with RA exposed to anti-tumor necrosis drugs may have increased abortion rates

Researchers unravel dual role of tumor necrosis factor in TB

Same factor that helps fight off severe inflammatory ailments also functions as enemy

Ulcerative colitis and Crohn’s disease treatments: an interview with Dr Parikh, vice president, general medicine, Takeda

Cytori receives patent for methods of treating renal diseases using ADRCs

Japan's MHLW approves XELJANZ for treatment of adults with rheumatoid arthritis

Male circumcision a 'staggeringly under-utilized tool'

New study may help develop targeted therapies for controlling tissue destruction

Cytomegalovirus employs a novel trick to hide from immune detection

Research finding aids efforts toward cytomegalovirus vaccine

Medication use and doctor visits drive up jaw necrosis-related costs

Inflammatory marker for schizophrenia treatment resistance, severity

RA patients who initiate anti-TNF therapies do not have higher risk of shingles: Study

Eye-rubbing may provoke, aggravate keratoconus

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Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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