Signaling Pathway News and Research

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Protein discovery opens door for new options in diagnosis and therapy of cancer

Oncologists at the University and University Hospital in Tübingen have discovered a new protein variant that plays an important role in the development and therapy response of cancer.

3 Apr 2019

Study reveals investigational drug as effective treatment for relapsed marginal zone lymphoma

A study at The University of Texas MD Anderson Cancer Center revealed the investigational drug umbralisib as an effective treatment for patients with relapsed marginal zone lymphoma.

1 Apr 2019

Binding affinities of PFASs to Baikal seal PPARα revealed using in vitro and in silico approaches

A team of researchers at Ehime University revealed the binding affinities of perfluoroalkyl substances (PFASs) to Baikal seal peroxisome proliferator-activated receptor α (PPARα) using in vitro and in silico approaches.

30 Mar 2019

Research reveals genomic basis of acute erythroid leukemia

Acute erythroid leukemia is a high-risk cancer with a dismal prognosis, uncertain genetic basis and controversy surrounding the diagnosis. That is changing, thanks to research led by St. Jude Children's Research Hospital that appears today in the journal Nature Genetics.

30 Mar 2019

New medication increases muscle and bone mass in mice

It is common knowledge that as people grow older they lose a large part of their muscle mass - and neither are their bones what they once were. Researchers from Aarhus University, Denmark, working together with researchers at Erasmus Medical Center in Rotterdam have now studied a new group of medication which could prove beneficial for the elderly and the chronically ill who suffer a loss of bone- and muscle mass.

28 Mar 2019

Scientists identify mechanism of impaired wound healing in diabetes

Researchers at Karolinska Institutet have identified a mechanism that can explain the impaired wound healing in diabetes which can lead to diabetic foot ulcers. The study is published in the scientific journal PNAS, Proceedings of the National Academy of Sciences.

26 Mar 2019

Promising gene therapy could restore vision in humans

It was surprisingly simple. University of California, Berkeley, scientists inserted a gene for a green-light receptor into the eyes of blind mice and, a month later, they were navigating around obstacles as easily as mice with no vision problems.

15 Mar 2019

Researchers identify novel regulatory factor in bone formation

Researchers report the identification of a novel transcription factor that helps regulate the differentiation of mesenchymal stem cells into bone in mice.

11 Mar 2019

Mechanism through which bacteria attack the immune system discovered

A research team led by Prof. Dr. Winfried Römer and Dr. Elias Hobeika from the University of Freiburg and the University Medical Center in Ulm has discovered a mechanism with which bacteria activate white blood cells and attack an organism's immune system. The scientists recently published the results in the journal Science Signaling.

7 Mar 2019

Genetic manipulation can double life expectancy and increase health of offspring

By manipulating the genes that make humans age, researchers have discovered that lifespans can be doubled with a better quality of life for offspring.

6 Mar 2019

Colon cancer could be made more aggressive by common oral bacteria

Scientists have identified a common oral bacterium that accelerates colon cancer growth. The discovery could pave the way for new treatments.

5 Mar 2019

Researchers find how common oral bacteria accelerates growth of colon cancer

Researchers at the Columbia University College of Dental Medicine have determined how F. nucleatum -- a common oral bacteria often implicated in tooth decay -- accelerates the growth of colon cancer. The study was published online in the journal EMBO Reports.

4 Mar 2019

Increasing parent's lifespan improves fitness of offspring

Genetic manipulation that more than doubles lifespan also leads to better offspring - according to new collaborative research from the University of East Anglia and Uppsala University.

4 Mar 2019

Newly developed bioluminescence sensors pave way for drug discovery

Canadian researchers, working in partnership with Brazilian colleagues, have developed 13 bioluminescence sensors for use in testing the effectiveness of new medical drugs in the laboratory.

2 Mar 2019

Protein signaling in embryos is far more complex than previously thought

How cells in developing embryos communicate depends a great deal on context, according to scientists at Rice University.

2 Mar 2019

Columbia researchers unravel why some glioblastomas respond to immunotherapy

Columbia researchers have learned why some glioblastomas--the most common type of brain cancer--respond to immunotherapy. The findings could help identify patients who are most likely to benefit from treatment with immunotherapy drugs and lead to the development of more broadly effective treatments.

17 Feb 2019

New mechanism for lateral inhibition of cells discovered

"The winner takes it all, the loser standing small" - that's not just true in the famous ABBA song, but also in animal development. Frequently, a group of cells starts out all being the same. But then one cell puts the brake on its neighbors, sending inhibitory signals that stop their differentiation. The "winning" cell, in the end, is different from its neighbors.

15 Feb 2019