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Researchers develop the smallest CRISPR to date for genome editing

A compact and efficient CRISPR-Cas system, named CasMINI, could be broadly useful for cell-engineering and gene-therapy applications because it is easier to deliver into cells. The findings appear in a study publishing September 3 in the journal Molecular Cell.

4 Sep 2021

Stanford researchers engineer an efficient, multi-purpose, mini CRISPR system

The common analogy for CRISPR gene editing is that it works like molecular scissors, cutting out select sections of DNA. Stanley Qi, assistant professor of bioengineering at Stanford University, likes that analogy, but he thinks it's time to reimagine CRISPR as a Swiss Army knife.

4 Sep 2021

Weill Cornell receives NIH support to advance TB research

Tuberculosis (TB) is one of the deadliest infectious diseases in history and one of the few that naturally infects only humans.

4 Sep 2021

CAR T cells expressing a natural RNA can activate the body’s own T cells against solid tumors

Chimeric antigen receptor (CAR) T cell therapy, which uses engineered T cells to treat certain types of cancers, has often been a challenging approach to treating solid tumors. CAR T cells need to recognize a specific target on cancer cells to kill them.

2 Sep 2021

Trial tests effectiveness of two prospective stroke therapies over standard of care

Another goal of the study is to screen all participants for a mutation known to prevent clopidogrel, a prodrug, from being fully metabolized into its active form.

2 Sep 2021

Immune cells present in tumors from head and neck cancer patients, study reports

A new study from scientists at Emory Vaccine Center and Winship Cancer Institute of Emory University reports that the immune cells that are the major targets of immune checkpoint inhibitors are present in tumors from head and neck cancer patients.

2 Sep 2021

Distinct changes found in cancer and non-cancer immune cells in Waldenstrom macroglobulinemia

A new study by researchers at Winship Cancer Institute of Emory University finds that cancer-associated mutations originate in blood progenitor cells, leading to distinct changes in both cancer and non-cancer immune cells in Waldenstrom macroglobulinemia (WM), a type of non-Hodgkin lymphoma and its precursor IgM monoclonal gammopathy of undetermined significance (MGUS).

2 Sep 2021

Mutual gaze with a robot affects human neural activity, research finds

Gaze is an extremely powerful and important signal during human-human communication and interaction, conveying intentions and informing about other's decisions. What happens when a robot and a human interact looking at each other?

2 Sep 2021

Growing use of mechanical circulatory support causes moral distress among clinicians

The growing use of mechanical circulatory support (MCS) may contribute to high levels of moral distress for clinicians who regularly care for critically ill patients receiving the aggressive but life-sustaining therapy, according to a study in American Journal of Critical Care.

1 Sep 2021

Study could pave way for an effective approach to amblyopia treatment

Amblyopia is the most common cause of vision loss in children, according to the U.S. National Eye Institute.

1 Sep 2021

Cultured cartilage cells from the nasal septum could help relieve osteoarthritis in the knee

Cartilage cells from the nasal septum can not only help repair cartilage injuries in the knee – according to researchers from the University of Basel and the University Hospital of Basel, they can also withstand the chronic inflammatory tissue environment in osteoarthritis and even counteract the inflammation.

1 Sep 2021

First-in-human trial proves feasibility of Temporally Feathered Radiation Therapy

Researchers from Cleveland Clinic and OhioHealth have published results from a first-in-human trial evaluating feasibility of Temporally Feathered Radiation Therapy (TFRT), which is designed to reduce the toxicity of radiation treatment.

1 Sep 2021

Cellular protein may be a potential new target for treating osteoporosis

A cellular protein whose normal function appears to suppress bone formation may be a potential new target for treating osteoporosis, suggests a collaborative study led by Weill Cornell Medicine and NewYork-Presbyterian investigators.

1 Sep 2021

First pharmacological treatment option for patients with a severe form of epilepsy

Epilepsy comes in a variety of forms. Those affected by a genetically de- termined variety have severe epileptic seizures as early as the first year of life.

1 Sep 2021

Implanted cells deliver a biologic drug in response to inflammation in rheumatoid arthritis

With a goal of developing rheumatoid arthritis therapies with minimal side effects, researchers at Washington University School of Medicine in St. Louis have genetically engineered cells that, when implanted in mice, will deliver a biologic drug in response to inflammation.

1 Sep 2021

Family of proteins could be effective in reducing damage from ischemic stroke

Boosting a family of naturally occurring proteins that dampens inflammation in the body has been shown to be effective in reducing damage from an ischemic stroke, according to preclinical researchers at The University of Texas Health Science Center at Houston.

1 Sep 2021

Saliva test screenings contribute to low transmission of COVID-19 in schools for children with IDD

Studies have determined that in-school transmission of the virus that causes COVID-19 is rare when masking, social distancing and other safety protocols are followed.

1 Sep 2021

Impact of neoadjuvant concurrent chemoradiation on exosomal markers expression in colorectal cancer

Oncotarget published "The impact of neoadjuvant concurrent chemoradiation on exosomal markers (CD63 and CD9) expression and their prognostic significance in patients with rectal adenocarcinoma" which reported that the impact of neoadjuvant concurrent chemoradiation on exosomal markers expression and their prognostic significance in patients with rectal adenocarcinoma are yet to be explored.

1 Sep 2021

Research confirms link between antibiotic use and increased risk of colon cancer

There is a clear link between taking antibiotics and an increased risk of developing colon cancer within the next five to ten years. This has been confirmed by researchers at Umeå University, Sweden, after a study of 40,000 cancer cases. The impact of antibiotics on the intestinal microbiome is thought to lie behind the increased risk of cancer.

1 Sep 2021

GripAble device helps stroke patients with arm weakness to do more physical training

Over five million people in the UK live with arm weakness, with stroke damage accounting for one million people of those people.

1 Sep 2021

Therapy News and Research

Researchers develop the smallest CRISPR to date for genome editing

Stanford researchers engineer an efficient, multi-purpose, mini CRISPR system

Weill Cornell receives NIH support to advance TB research

CAR T cells expressing a natural RNA can activate the body’s own T cells against solid tumors

Trial tests effectiveness of two prospective stroke therapies over standard of care

Immune cells present in tumors from head and neck cancer patients, study reports

Distinct changes found in cancer and non-cancer immune cells in Waldenstrom macroglobulinemia

Mutual gaze with a robot affects human neural activity, research finds

Growing use of mechanical circulatory support causes moral distress among clinicians

Study could pave way for an effective approach to amblyopia treatment

Cultured cartilage cells from the nasal septum could help relieve osteoarthritis in the knee

First-in-human trial proves feasibility of Temporally Feathered Radiation Therapy

Cellular protein may be a potential new target for treating osteoporosis

First pharmacological treatment option for patients with a severe form of epilepsy

Implanted cells deliver a biologic drug in response to inflammation in rheumatoid arthritis

Family of proteins could be effective in reducing damage from ischemic stroke

Saliva test screenings contribute to low transmission of COVID-19 in schools for children with IDD

Impact of neoadjuvant concurrent chemoradiation on exosomal markers expression in colorectal cancer

Research confirms link between antibiotic use and increased risk of colon cancer

GripAble device helps stroke patients with arm weakness to do more physical training

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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