Enzyme News and Research

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Role of enzyme GSTP1-1 in progression of cancer, other diseases associated with increased cell proliferation

Telik, Inc. today announced the publication of a review in the journal, Cell Death and Differentiation: Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death; http://www.nature.com/cdd/journal/vaop/ncurrent/full/cdd201080a.html. This review describes recent advances in the understanding of the important role that the enzyme GSTP1-1 plays in the progression of cancer and other diseases associated with increased cell proliferation.

13 Jul 2010

SPET-085 is effective in blocking critical enzyme that leads to BPH: Study

A new study, published in the July issue of Advances in Therapy, revealed that a novel saw palmetto extract, SPET-085, is as effective as finasteride, the standard prescription drug therapy, in blocking the critical enzyme that leads to benign prostatic hyperplasia.

13 Jul 2010

New study on impact of bortezomib on mantle cell lymphoma

A new study by researchers from the John Theurer Cancer Center at Hackensack University Medical Center sheds light on how bortezomib (VELCADE-), the first in a new class of cancer drugs known as proteasome inhibitors, works in mantle cell lymphoma. The study also provides preliminary evidence for which patients might benefit most from bortezomib.

13 Jul 2010

CSHL scientists reverse symptoms of Type III SMA using ASOs

The devastating, currently incurable motor-neuron disease spinal muscular atrophy might soon be treated with tiny, chemically modified pieces of RNA called antisense oligonucleotides.

13 Jul 2010

Scientists receive $1.6M in new funding to advance healthcare research

University of Montreal scientists have received $1.6 in new funding to advance healthcare research over the next three years, as part of a Government of Canada announcement to support 31 research projects at 12 universities across the nation. Some $13 million in funding, from the Collaborative Health Research Projects program, will be awarded over three years to foster collaborations between scientists from the natural, engineering and health sciences.

13 Jul 2010

Research findings could offer new approach to diabetes therapy, nutrition experts say

Nutrition experts at Oregon State University have essentially "cured" laboratory mice of mild, diet-induced diabetes by stimulating the production of a particular enzyme. The findings could offer a new approach to diabetes therapy, experts say, especially if a drug could be identified that would do the same thing, which in this case was accomplished with genetic manipulation.

13 Jul 2010

BRAIN AG acquires a minority share in Enzymicals AG

BRAIN AG, one of the leading European white biotechnology companies, has acquired a minority share in Enzymicals AG. This biotechnology company was founded in 2009 as a spin-off by a management team from the workgroup led by Prof. Dr. Uwe Bornscheuer from Ernst-Moritz-Arndt University Greifswald with support from the EXIST-Programme of the Federal Ministry for Economy and Technology.

12 Jul 2010

Subtle mutation affecting epigenome may lead to inherited form of mental retardation: Researchers

A subtle mutation affecting the epigenome –- a set of dynamic factors that influence gene activity -- may lead to an inherited form of mental retardation that affects boys, find researchers at Children's Hospital Boston. The disorder, which also involves cleft lip or cleft palate, appears to hinge on an enzyme working in a biological pathway that may offer several potential drug targets.

12 Jul 2010

Sirtuin1 protein promotes memory, brain flexibility: MIT researchers

The same molecular mechanism that increases life span through calorie restriction may help boost memory and brainpower, researchers at MIT's Picower Institute for Learning and Memory report in the July 11 issue of Nature.

12 Jul 2010

Simple, routine test for detecting subtle onset of diabetes and prediabetes

Having discovered a dramatic increase of an easy-to-detect enzyme in the red blood cells of people with diabetes and prediabetes, Johns Hopkins scientists say the discovery could lead to a simple, routine test for detecting the subtle onset of the disease, before symptoms or complications occur and in time to reverse its course.

9 Jul 2010

Female mice that lack fucose mutarotase gene exhibit male-like sexual behavior

The mammalian fucose mutarotase enzyme is known to be involved in incorporating the sugar fucose into protein. Female mice that lack the fucose mutarotase (FucM) gene refuse to let males mount them, and will attempt copulation with other female mice. Researchers writing in BioMed Central's open access journal BMC Genetics created the FucM mouse mutants in order to investigate the role of this enzyme in vivo.

9 Jul 2010

Researcher uses biopharmaceutical proteases to develop novel therapy for Alzheimer's disease

A University of Oklahoma researcher is developing a novel therapy for Alzheimer's disease using "biopharmaceutical proteases" to attack the toxic plaque that builds up in the brain of an Alzheimer's patient-an approach that he predicts will be lower in cost and higher in effectiveness than current therapies.

9 Jul 2010

Research finding uncovers alternative treatments for people with hereditary colorectal cancer

By solving the three-dimensional structure of a protein involved in repairing DNA errors, a group of McMaster University researchers have revealed new avenues to develop assessment tools and alternative treatments for people living with hereditary colorectal cancers.

9 Jul 2010

IRIC scientists identify vitamin B3 as potential antifungal treatment

A team of scientists from the Institute for Research in Immunology and Cancer (IRIC) of the University of Montreal have identified vitamin B3 as a potential antifungal treatment. Led by IRIC Principal Investigators Martine Raymond, Alain Verreault and Pierre Thibault, in collaboration with Alaka Mullick, from the Biotechnology Research Institute of the National Research Council Canada, the study is the subject of a recent article in Nature Medicine.

9 Jul 2010

Biomagnetics, LANL collaborate to develop device for tuberculosis diagnosis

Biomagnetics Diagnostics Corp., a developer of revolutionary technology for diagnostic systems for HIV, hepatitis, tuberculosis and malaria detection, today announced the signing of an agreement with Los Alamos National Security, LLC where Los Alamos National Laboratory's scientific and engineering staffs will attempt to identify new potential human tuberculosis biomarkers and will develop a validated assay to detect human tuberculosis using a currently known biomarker to be used in combination with the waveguide-based optical biosensor platform.

9 Jul 2010

Calithera Biosciences completes Series A financing totaling $40M

Calithera Biosciences, a company developing novel oncology therapeutics, today announced the completion of a Series A financing totaling $40 million. Morgenthaler Ventures led the financing with U.S. Venture Partners, Advanced Technology Ventures, Delphi Ventures and Mission Bay Capital also participating in the round. The capital will be used to support the company's pioneering efforts to develop activators of caspases, the proteases that promote apoptotic cell death, for the treatment of cancer and other proliferative diseases.

8 Jul 2010

Japanese scientists identify long-elusive enzyme necessary for proper regulation of cilia

It's safe to say that cilia, the hairlike appendages jutting out from the smooth surfaces of most mammalian cells, have long been misunderstood - underestimated, even.

8 Jul 2010

Scientists shrink distant sarcomas with genetically reprogrammed herpes virus and anti-vascular drug

Scientists have used a genetically reprogrammed herpes virus and an anti-vascular drug to shrink spreading distant sarcomas designed to model metastatic disease in mice – still an elusive goal when treating humans with cancer, according to a study in the July 8 Gene Therapy.

8 Jul 2010

PolyMAC technique retrieves specific proteins needed to study formation of cancer cells

A Purdue University researcher can better retrieve specific proteins needed to study how cancer cells form by using a newly developed technique and synthetic nanopolymer.

8 Jul 2010

Aethlon Medical files provisional patent on behalf of ESI for exosome detection assay

Aethlon Medical, Inc., the pioneer in developing therapeutic filtration devices to address infectious disease and cancer, announced today that it has filed a provisional patent on behalf of its wholly owned subsidiary Exosome Sciences, Inc. (ESI), relating to the development of an assay that will allow researchers to detect exosomes in blood and other fluids.

8 Jul 2010

Enzyme News and Research

Role of enzyme GSTP1-1 in progression of cancer, other diseases associated with increased cell proliferation

SPET-085 is effective in blocking critical enzyme that leads to BPH: Study

New study on impact of bortezomib on mantle cell lymphoma

CSHL scientists reverse symptoms of Type III SMA using ASOs

Scientists receive $1.6M in new funding to advance healthcare research

Research findings could offer new approach to diabetes therapy, nutrition experts say

BRAIN AG acquires a minority share in Enzymicals AG

Subtle mutation affecting epigenome may lead to inherited form of mental retardation: Researchers

Sirtuin1 protein promotes memory, brain flexibility: MIT researchers

Simple, routine test for detecting subtle onset of diabetes and prediabetes

Female mice that lack fucose mutarotase gene exhibit male-like sexual behavior

Researcher uses biopharmaceutical proteases to develop novel therapy for Alzheimer's disease

Research finding uncovers alternative treatments for people with hereditary colorectal cancer

IRIC scientists identify vitamin B3 as potential antifungal treatment

Biomagnetics, LANL collaborate to develop device for tuberculosis diagnosis

Calithera Biosciences completes Series A financing totaling $40M

Japanese scientists identify long-elusive enzyme necessary for proper regulation of cilia

Scientists shrink distant sarcomas with genetically reprogrammed herpes virus and anti-vascular drug

PolyMAC technique retrieves specific proteins needed to study formation of cancer cells

Aethlon Medical files provisional patent on behalf of ESI for exosome detection assay

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