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New treatment approach shows promise in reversing hormone resistance in breast cancer

A collaborative study between LSU Health New Orleans School of Medicine, the University of Rochester and Cellestia Biotech AG, a biopharmaceutical company headquartered in Basel, Switzerland, provides compelling evidence that combining an investigational oral drug with standard-of-care medications reverts hormone resistance and increases Rx effectiveness in experimental models of estrogen-receptor positive (ER+) and triple-negative breast cancers (TNBC), respectively.

9 Aug 2023

Researchers design a probiotic to suppress autoimmunity in the brain

Brigham researchers are working on a new approach to target autoimmunity in the brain leverages designer bacteria to make treatment safer and more effective.

9 Aug 2023

Deep-learning technology could help scientists to develop personalized immunotherapies and vaccines

Deep-learning technology developed by a team of Johns Hopkins engineers and cancer researchers can accurately predict cancer-related protein fragments that may trigger an immune system response.

9 Aug 2023

New mechanism discovered for coordinating organ development

Researchers at the Instituto Gulbenkian de Ciência (IGC, Oeiras) and Max Planck Institute of Cell Biology and Genetics (MPI-CBG, Dresden) identified a new mechanism that exposes some of the multitasking abilities embryos need to build a functional retina, the sensory part of the central nervous system responsible for vision.

9 Aug 2023

Mass spectrometry-based secretome approach reveals key players in astroglial barrier function

In neuroinflammation, immune cells such as leukocytes cross the blood-brain barrier. One key to this is the gelatinases matrix metalloproteinase (MMP)-2 and -9. Until now, the substrates of these enzymes involved in the process were unknown.

9 Aug 2023

Researchers develop antibody drugs from tobacco plants for cancer treatment

For the first time in Thailand, lecturers at Chulalongkorn University's Faculty of Pharmaceutical Sciences have successfully developed antibody from tobacco plants with inhibitory effects on the growth of cancer cells in laboratory animals.

9 Aug 2023

Study reveals the genetics of hair whorl direction

The first gene mapping study on human scalp hair whorls not only shows that hair whorl direction has a genetic basis, but also that it is affected by multiple genes.

9 Aug 2023

Review examines visual disturbances among Parkinson’s disease patients

In a recent review published in Brain Sciences, researchers reviewed existing data on visual impairments among Parkinson’s disease (PD) patients.

9 Aug 2023

Are mushrooms an effective early dietary intervention for Alzheimer’s Disease?

In a study published in the journal Foods, researchers reviewed available literature on the potential anti-Alzheimer's disease properties of mushrooms.

9 Aug 2023

Pioneering study links testicular cancer among military personnel to ‘forever chemicals’

Gary Flook served in the Air Force for 37 years, as a firefighter at the now-closed Chanute Air Force Base in Illinois and the former Grissom Air Force Base in Indiana, where he regularly trained with aqueous film forming foam, or AFFF — a frothy white fire retardant that is highly effective but now known to be toxic.

9 Aug 2023

Effect of mutations in cancer-driving genes across human cancers

Effect of mutations in cancer-driving genes across human cancers.

9 Aug 2023

The impact of epigenetic features on breast cancer treatment and outcomes

The impact of epigenetic features on breast cancer treatment and outcomes.

9 Aug 2023

Nanotechnology's triple threat: Advancing precision cancer treatment

The design of tumor tissue-, cell-, and organelle-targeted cancer nanomedicines.

9 Aug 2023

The immune-modulatory effect of lenvatinib investigated in new study

Researchers explore the effect of lenvatinib treatment on patients with advanced thyroid cancer.

9 Aug 2023

High-level BPA exposure may affect male fertility

Scientists discuss the effect of bisphenol A on human male fertility.

9 Aug 2023

Spatially-resolved macrophage phenotyping in liver disease-related research

This review manuscript highlights the relevance of spatially-resolved macrophage phenotyping in liver disease-related research.

8 Aug 2023

Dendritic cells found to kill CD47-deficient T cells

Researchers at Kobe University discovered an entirely new and unexpected mechanism by which the immune system can get rid of cells lacking molecules that identify them as part of the self in mice.

8 Aug 2023

Nationwide Children's Hospital pioneers new gene therapy for Duchenne muscular dystrophy

In a landmark moment for the Abigail Wexner Research Institute at Nationwide Children's, a 5-year-old from Bellefontaine, Ohio, received the first dose of a recently approved gene therapy for Duchenne muscular dystrophy at Nationwide Children's Hospital, where the therapy was invented and initially tested.

8 Aug 2023

RAGE plays key role in cellular mechanisms of plasticity in aggressive triple-negative breast cancer

Published online ahead of print in the journal Oncogene , a study led by Josep Villanueva, an Investigator at the Vall d'Hebron Institute of Oncology (VHIO), shows that the receptor for advanced glycation end-product (RAGE) plays a key role in cellular mechanisms of plasticity in mesenchymal triple-negative breast cancer (TNBC) that transform epithelial cells into mesenchymal cells as potent drivers of cancer cell proliferation and tumor invasion.

8 Aug 2023

Nanoscale tattoos for tracking the health of individual cells

Engineers have developed nanoscale tattoos - dots and wires that adhere to live cells - in a breakthrough that puts researchers one step closer to tracking the health of individual cells.

8 Aug 2023