Apolipoprotein News and Research

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New review sheds light on links between Alzheimer's and metabolic syndrome

Alzheimer's disease (AD), the most common form of dementia, continues to remain one of modern medicine's greatest challenges.

18 Feb 2025

Olpasiran significantly lowers "bad cholesterol" linked to cardiovascular risk

The RNA inhibitor olpasiran significantly reduces a type of "bad cholesterol" that's associated with a high risk of cardiovascular events, according to results from an analysis by a Mount Sinai researcher of a phase 2 trial.

13 Feb 2025

Study unlocks structural secrets of ApoB100 protein linked to heart disease

Low-density lipoproteins (LDL) - commonly known as bad cholesterol - have long been on scientists' radar as a major contributor to heart disease.

3 Feb 2025

Prolonged REM sleep latency linked to Alzheimer’s disease biomarkers

Research indicates longer REM latency is associated with higher Alzheimer's biomarkers, pointing to its potential as an early indicator of neurodegeneration.

29 Jan 2025

Study links oral microbiome to cognitive function in older adults

The microbial ecosystems within our mouths may affect our cognitive function as we age, according to a study. Interventions such as prebiotics, including dietary nitrate, have potential for delaying cognitive decline.

28 Jan 2025

APOBEC proteins linked to DNA repeat expansion in Huntington's disease

People genetically susceptible to Huntington's disease often see their movement, mood, and cognition decline slowly over time.

22 Jan 2025

By 2060, 1 million U.S. adults are projected to develop dementia annually

The lifetime risk of dementia is 42%, with significant variations by race and sex, underscoring the importance of public health strategies for prevention.

13 Jan 2025

Can green tea help prevent cognitive decline?

Higher green tea consumption significantly reduces cerebral white matter lesions in older adults, offering potential protective effects against cognitive decline.

8 Jan 2025

Study shows beef can be part of a heart-healthy diet

A recently published, comprehensive systematic review and meta-analysis has added to the growing body of evidence showing that beef can be enjoyed in a heart-healthy diet.

20 Dec 2024

Key to LDL clearance uncovered: Structural details of apoB100-LDLR binding emerge

Researchers reveal the structural details of apoB100's interaction with LDL receptors, offering insights into LDL dimerization and potential treatments for familial hypercholesterolemia.

12 Dec 2024

Early ovarian removal and APOE4 increase Alzheimer's risk in women

New research published by a team of researchers from the University of Toronto in collaboration with colleagues from the University of Alberta has found that women who have had both ovaries surgically removed before the age of 50 and carry a variant of the apolipoprotein gene, the APOE4 allele, are at high risk of late-life Alzheimer disease (AD). Use of hormone therapy mitigates this risk.

5 Dec 2024

Replacing carbohydrates with protein and fat improves cholesterol profiles in type 2 diabetes

Research indicates that a carbohydrate-reduced, high-protein diet improves lipid metabolism and reduces liver fat in type 2 diabetes without weight loss.

5 Dec 2024

Men face sharper brain aging from obesity and heart risks

Obesity and cardiovascular risk factors accelerate brain volume loss, with males experiencing earlier and more significant impacts, highlighting the importance of early interventions to prevent neurodegeneration.

1 Dec 2024

Scientists uncover cerebrospinal fluid markers for Alzheimer's detection and treatment

Researchers map the unique genetic regulation of proteins in human cerebrospinal fluid, identifying potential targets for Alzheimer’s treatments.

12 Nov 2024

AI model predicts Alzheimer’s progression with new insights into racial and sex-based disparities

Researchers developed a deep learning model that predicts Alzheimer’s progression with high accuracy, highlighting differences in disease progression across race and sex.

5 Nov 2024

New Alzheimer's guidelines focus on risk, not diagnosis, in healthy adults

Researchers from the International Working Group recommend categorizing biomarker-positive, cognitively normal individuals as "at risk" for Alzheimer's to avoid unnecessary diagnoses and emphasize preventive care.

4 Nov 2024

Inside the Alzheimer's Association: Dr. Heather Snyder on Driving Research and Collaboration

Heather Snyder discusses the Alzheimer's Association's research initiatives, breakthroughs in diagnostics, and the importance of collaboration in dementia care.

28 Oct 2024

MHRA greenlights donanemab for early stage Alzheimer’s disease

The Medicines and Healthcare products Regulatory Agency (MHRA) has today, 23 October 2024, approved a license for the medicine donanemab (Kisunla) for use in the early stages of Alzheimer’s disease, following a thorough review of the benefits and risks.

26 Oct 2024

Taurine supplementation linked to reduced atherosclerotic plaque development

Previous studies suggest that taurine supplementation may attenuate atherosclerosis by reducing lipid levels. However, energy drinks containing taurine have been shown to increase blood pressure, a key risk factor for atherosclerosis. Thus, the role of taurine in atherosclerosis remains controversial.

26 Oct 2024

Could heparin offer new hope in the fight against dementia?

Heparin therapy delays Alzheimer's diagnosis by one to two years, offering potential insights into new protective treatments. Large-scale health records show a promising association between the anticoagulant and delayed dementia onset.

10 Oct 2024