CD4 News and Research

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m6A modification as a potential therapeutic target for autoimmune diseases

N6-methyladenosine (m6A) is the most extensive studied RNA modification across various species, and the important effect of m6A modification in immune system has been revealed in distinct contexts, including mRNA metabolism, cell differentiation, proliferation and response to stimulation.

14 Jul 2023

Scientists discover mechanism of cell death in people living with HIV

Professor Simona Stäger's team has made a breakthrough in the study of the human immunodeficiency virus (HIV).

13 Jul 2023

IL-9 identified as contributor to viral spread and airway inflammation in COVID-19

Researchers used a K18-hACE2 transgenic (ACE2.Tg) mouse model to demonstrate that interleukin-9 (IL-9).

13 Jul 2023

New study shows circulating anti-insulin CD4 T cells reflect progression of anti-islet immunity

In a recent study published in Science Translational Medicine, researchers profile antigen-specific helper clusters of differentiation 4-positive (CD4+) T-lymphocytes to determine anti-islet autoimmunity among mice and humans.

9 Jul 2023

Prolonged T-cell response during severe COVID-19 does not contribute to long COVID

Persistent immune activation and elevated cytokine levels were observed in patients with severe COVID-19, even months after recovery. However, the correlation between immune activation and long COVID symptoms appeared to be independent, suggesting other factors influencing disease severity.

9 Jul 2023

Researchers identify an enzyme that plays a critical role in the late stages of HIV replication

Researchers at Johns Hopkins Medicine, in collaboration with researchers at the National Institutes of Health, report that two new studies in mice with a humanized immune system and human cell lines have identified an enzyme that plays a critical role in the late stages of HIV replication.

6 Jul 2023

mRNA rabies vaccine induces durable immune response in macaques

Novel mRNA vaccine for rabies shows enhanced immune response with higher antibody levels and improved cross-neutralization, indicating potential for a broadly protective vaccine against related lyssavirus strains.

26 Jun 2023

Scientists identify potential biomarkers associated with positive immunotherapy response

Scientists at the UCLA Jonsson Comprehensive Cancer Center have identified potential new biomarkers that could indicate how someone diagnosed with metastatic melanoma will respond to immunotherapy treatment.

26 Jun 2023

Scientists discover new way to defeat invisible cancer cells

Modern immunotherapies boost the body's own defenses against cancer. They activate killer T cells of the immune system that can specifically recognize and destroy cancer cells.

23 Jun 2023

The use of bacterial colonists as therapy carriers is gaining interest for treating cancer

Study describes the use of engineered commensal bacteria to increase antitumor immunity.

23 Jun 2023

Unlocking HIV cure: Study highlights allogeneic immunity as key mechanism in eradicating latent virus reservoirs

Allogeneic stem cell transplantation with CCR5Δ32/Δ32 donors shows potential for HIV cure. Alloimmunity and CCR5 deficiency play significant roles in viral reservoir clearance.

19 Jun 2023

Brain microglia serve as a stable viral reservoir for latent HIV

As a part of its life cycle, the human immunodeficiency virus-1 (HIV) inserts a copy of its DNA into human immune cells. Some of these newly infected immune cells can then transition into a dormant, latent state for a long period of time, which is referred to as HIV latency.

16 Jun 2023

Penn research bolsters scientific understanding behind why some people are more prone to allergies

New research is bolstering scientific understanding behind why some people are more prone to allergies than others.

15 Jun 2023

Unlocking the secret to lifelong health: the power of optimal immune resilience

Researchers assessed immune resilience (IR) metrics in individuals across diverse infectious and non-infectious models.

15 Jun 2023

Stronger defense: symptomatic malaria provides durable protection against reinfection

Researchers evaluated the immune protection conferred by symptomatic and asymptomatic P. falciparum.

14 Jun 2023

Immune resilience promotes longevity and resistance to infections

Researchers from The University of Texas Health Science Center at San Antonio, working with collaborators in five countries, today revealed that the capacity to resist or recover from infections and other sources of inflammatory stress -; called "immune resilience" -; differs widely among individuals.

13 Jun 2023

CD4 News and Research

m6A modification as a potential therapeutic target for autoimmune diseases

Scientists discover mechanism of cell death in people living with HIV

IL-9 identified as contributor to viral spread and airway inflammation in COVID-19

New study shows circulating anti-insulin CD4 T cells reflect progression of anti-islet immunity

Prolonged T-cell response during severe COVID-19 does not contribute to long COVID

Researchers identify an enzyme that plays a critical role in the late stages of HIV replication

mRNA rabies vaccine induces durable immune response in macaques

Scientists identify potential biomarkers associated with positive immunotherapy response

Scientists discover new way to defeat invisible cancer cells

The use of bacterial colonists as therapy carriers is gaining interest for treating cancer

Unlocking HIV cure: Study highlights allogeneic immunity as key mechanism in eradicating latent virus reservoirs

Brain microglia serve as a stable viral reservoir for latent HIV

Penn research bolsters scientific understanding behind why some people are more prone to allergies

Unlocking the secret to lifelong health: the power of optimal immune resilience

Stronger defense: symptomatic malaria provides durable protection against reinfection

Immune resilience promotes longevity and resistance to infections

Antiretroviral treatment efficiently suppresses penile HIV replication

Study raises new hopes for blood cancer patients with an incomplete response to CAR T cell therapy

Two studies spotlight intestinal T cells that could be targeted to prevent resistance to ICB cancer therapy

Scientists identify the IL-17 protein as a determining factor in skin aging

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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