Knee Arthroplasty News and Research

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Knee arthroplasty or knee replacement surgery has developed to its present advanced stage over the last few decades. This is mainly due to technical advances and better understanding of knee pathophysiology and functions.

Study: Total knee replacements in younger patients with juvenile arthritis last for 10 years

When you think of knee replacement surgery, you generally envision an older adult with painful arthritis. But the procedure is also used for younger patients with juvenile idiopathic arthritis whose joints have been severely damaged by the disease. Because the surgery in younger patients is relatively rare, little data exist on the longevity of knee replacements in JIA patients.

19 Mar 2013

Adynxx initiates AYX1 Phase 2 study to prevent post-surgical pain

Adynxx, a clinical-stage pharmaceutical company developing a first-in-class platform of therapeutics to address pain at its molecular roots, announced today that the first patient was dosed in a Phase 2 study of its lead investigational drug candidate for the prevention of post-surgical pain, AYX1.

26 Feb 2013

Knee replacement pain predicted by comorbidity

Research may help physicians give patients undergoing total knee arthroplasty a realistic expectation of surgery outcome based on their overall physical and mental health, US researchers believe.

21 Jan 2013

Anesthesia choice may benefit knee arthroplasty patients

Spinal anesthesia could reduce the risk for postoperative complications in select patients undergoing total knee arthroplasty, US researchers say.

28 Dec 2012

Comorbidity could alter joint arthroplasty prognosis

The long-term outcome of hip and knee arthroplasty may be significantly influenced by comorbidity, suggest results from a large register-based study of over 96,000 osteoarthritis patients.

22 Dec 2012

Cempra commences CEM-102 Phase 2 trial in prosthetic joint infections

Cempra, Inc., a clinical-stage pharmaceutical company focused on developing antibiotics to meet critical medical needs in the treatment of bacterial infectious diseases, today announced the initiation of its Phase 2 clinical trial of CEM-102 in patients with prosthetic joint infections (PJIs).

15 Dec 2012

No differences between computer-navigated and traditional TKA related to knee function, pain

For many years, the use of computer-assisted navigation has been touted as improving the positioning, sizing and alignment of replacement knee joints, resulting in greater durability of joints and overall improvement in patient movement. However, new research published in the Journal of Bone and Joint Surgery (JBJS) found no difference in knee function, alignment or durability/survivorship between joints positioned and completed with the help of computer navigation, and those replaced with conventional total knee arthroplasty (TKA) procedures.

21 Nov 2012

Hydrocortisone protects bilateral knee replacement patients

Repeat doses of corticosteroids may protect patients undergoing bilateral total knee arthroplasty from postoperative side effects such as fever, pain, and acute respiratory distress, research suggests.

16 Nov 2012

Isis commences ISIS-FXIRx Phase 2 study in knee replacement surgery patients

Isis Pharmaceuticals, Inc. announced the initiation of a Phase 2 comparator-controlled study evaluating ISIS-FXIRx in patients undergoing knee replacement surgery, also referred to as total knee arthroplasty (TKA).

29 Oct 2012

Neuraxial anesthesia should be promoted for bilateral total knee replacements: HSS

Using regional anesthesia rather than general anesthesia reduces the need for blood transfusions in patients undergoing bilateral total knee replacement, according to a new study by researchers at Hospital for Special Surgery, in New York City.

29 Oct 2012

Obese patients more likely to have complications after total knee replacement surgery

Obese patients have a greater risk of complications following total knee replacement surgery, including post-surgical infections, according to a new literature review recently published in the Journal of Bone and Joint Surgery (JBJS).

25 Oct 2012

Leg press power best indicator of function after knee arthroplasty

Leg press power is a better indicator of performance-based and self-reported functionality after total knee arthroplasty than knee extension strength, show study findings.

23 Oct 2012

Obesity does not affect VTE risk after knee surgery

Being morbidly obese does not increase the risk for developing venous thromboembolism after total knee arthroplasty surgery, report US researchers.

15 Oct 2012

Dramatic rise in total knee arthroplasty, associated infection rates over past 20 years

Study findings document a steep rise in total knee arthroplasty procedures over the past 20 years, being driven by both an increase in the number of patients enrolled in Medicare and greater per capita utilization.

1 Oct 2012

Study finds increase in number of total knee replacements among U.S. Medicare population

Total knee replacement is a very common and safe surgery that's used to relieve severe pain and disability caused by knee osteoarthritis, and to improve patients' quality of life. However, it's also very expensive at approximately $15,000 per procedure. With an estimated 600,000 total knee replacements performed annually in the United States, the aggregate annual cost for total knee replacement (also known as total knee arthroplasty or TKA) is $9 billion.

27 Sep 2012

Arthroplasty wound complications linked to oral anticoagulant use

Multicenter research suggests that recovery from hip or knee arthroplasty may be significantly affected by choice of pharmaceutical thromboprophylaxis.

21 Sep 2012

Obesity no barrier to knee replacement surgery

Health policy should not withhold total knee arthroplasty from patients on the basis of obesity, say UK researchers.

3 Sep 2012

Patellar length affects tendon contact after posterior-stabilized TKA

In patients undergoing posterior-stabilized total knee arthroplasty, patellar ligament length has the greatest effect on the extent of tendo-femoral contact, say US researchers who have developed a model to aid clinical decision-making.

3 Aug 2012

Knee surgery blood loss reduced with single tranexamic acid dose

A single intraoperative dose of tranexamic acid is effective at reducing blood loss in patients undergoing minimally invasive total knee arthroplasty, research suggests.

20 Jul 2012

Hot topics in the Journal of Bone and Joint Surgery

Airport security screening has increased substantially during the past decade, while joint replacement procedures also continue to rise. According to the American Academy of Orthopaedic Surgeons (AAOS), in 2009, nearly 300,000 total hip replacements (THR) were performed in the United States.

6 Apr 2012