Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Whole body imaging detects more myeloma-defining disease, allows treatment to be initiated earlier

Researchers from King's College London have shown that whole body magnetic resonance imaging (WBMRI) not only detects more myeloma-defining disease than positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) but that it also allows critical treatment to be initiated earlier.

21 Jan 2021

Designer DNA agent reduces myeloma stem cell abundance, lowers disease burden in mice

Many patients with multiple myeloma, a type of blood cancer, eventually develop resistance to one treatment after another. That's in part because cancer stem cells drive the disease -- cells that continually self-renew. If a therapy can't completely destroy these malignant stem cells, the cancer is likely to keep coming back.

20 Jan 2021

Putatively immature dendritic cells may induce robust immune responses in young children

A study by Ludwig-Maximilians-Universitaet (LMU) in Munich researchers shows that putatively immature dendritic cells found in young children are able to induce robust immune responses. The results could lead to improved vaccination protocols.

20 Jan 2021

Modified natural killer cells show neutralizing and multivalent potential against SARS-CoV-2 in vitro

A new study suggests that modified natural killer cells, which express a chimeric antigen receptor using S309 antibody, can bind to and inactivate SARS-CoV-2 spike protein in vitro.

18 Jan 2021

Study: Fibroblast hormone promotes movement of hematopoietic stem cells

Discovery expected to contribute towards more effective methods of harvesting stem cells from bone marrow donors.

17 Jan 2021

Study offers a differentiated patient-specific solution in minimal residual disease testing

Exact Sciences Corp. today announced that it has acquired a worldwide exclusive license to the proprietary TARDIS technology from the Translational Genomics Research Institute (TGen), an affiliate of City of Hope.

15 Jan 2021

EGR1 protein acts as a master regulator of inflammation in macrophages, study suggests

Scientists at The Wistar Institute discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages.

14 Jan 2021

Scientists determine ideal dose of stem cells to control HIV

Scientists have determined the optimal conditions following a stem cell transplant that could control HIV without the need of an everyday pill, according to a study published today in eLife.

12 Jan 2021

MDC researchers develop a potent weapon against lymphomas

MDC researchers have developed a new approach to CAR T-cell therapy. The team has shown in Nature Communications that the procedure is very effective, especially when it comes to fighting follicular lymphomas and chronic lymphocytic leukemia, the most common type of blood cancer in adults.

11 Jan 2021

Researchers receive NIH grant to develop more effective flu vaccines

To build better vaccines, scientists want to know more about how our bodies make adequate numbers of effective, durable antibodies against the influenza virus.

11 Jan 2021

IU research findings could prevent common complication of blood stem cell transplantation in leukemia

Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center published promising findings today in the New England Journal of Medicine on preventing a common complication to lifesaving blood stem cell transplantation in leukemia.

7 Jan 2021

New cell therapy can boost immunotherapy against breast cancer

Boosting immune system T cells to effectively attack solid tumors, such as breast cancers, can be done by adding a small molecule to a treatment procedure called chimeric antigen receptor-T (CAR-T) cell therapy, according to a study by researchers at the UNC Lineberger Comprehensive Cancer Center.

4 Jan 2021

Study clarifies the effect of aging on hematopoietic stem cells

By transferring mouse aged hematopoietic stem cells (aged HSCs) to the environment of young mice (bone marrow niche), it was demonstrated that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem cells.

24 Dec 2020

Modulating BST2 expression on blood stem cells may help regulate cell activation during chronic infections

When a person has an infection, the body activates immune responses to fight it. IFNγ is an inflammatory molecule produced by the immune system that helps fight infections.

23 Dec 2020

Researchers establish BRIDGES program to synergize diagnostic efforts, patient outcome management

For over 20 years, the Genetics Service at the KK Women's and Children's Hospital (KKH) has been providing clinical care to patients with genetic disorders.

22 Dec 2020

South Korean city shows SARS-CoV-2 clade shift from V to GH over time

A new paper from South Korea describes the evolving SARS-CoV-2 genome in a single city, that of Gwangju, in the southwestern region of this country.

21 Dec 2020

Study shows benefits of integrated palliative and oncology care for patients with advanced AML

A first-of-its-kind intervention integrating palliative care early in the course of cancer therapy for patients with advanced acute myeloid leukemia (AML), a highly aggressive cancer of the blood and bone marrow, resulted in substantial improvements in patients' quality of life, mood and end-of-life care, a team of investigators has found.

17 Dec 2020

Scientists demonstrate a promising strategy for treating lymphomas

Scientists at Scripps Research have demonstrated a promising new strategy for treating lymphomas, a group of cancers that begin in infection-fighting cells of the immune system called lymphocytes.

16 Dec 2020

New class of targeted cancer drugs may prove effective in treating common types of leukemia

A new study by researchers in Cleveland Clinic's Taussig Cancer Institute and Lerner Research Institute describes a novel class of targeted cancer drugs that may prove effective in treating certain common types of leukemia.

15 Dec 2020

Researchers find new method for safe and effective delivery of medicines to the lungs

Investigators at Rutgers Cancer Institute of New Jersey and Rutgers New Jersey Medical School recently identified a new method for safe and effective delivery of medicines to the lungs that can be used for multiple clinical applications, potentially including aerosol vaccination.

10 Dec 2020