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HIV-exposed but uninfected individuals at risk of obesity and asthma-like symptoms

Adolescents and young adults who were born to mothers with HIV but remained uninfected themselves still face a greatly heightened risk of obesity and asthma-like symptoms, researchers from Massachusetts General Hospital have found.

15 Nov 2019

Research explains why immunotherapy fails against prostate cancer bone metastases

Prostate cancer that spreads to the bone triggers the destruction of bone tissue that, in turn, thwarts the effectiveness of immune checkpoint inhibitors by blocking the development of T cells that are crucial to successful treatment, researchers from The University of Texas MD Anderson Cancer Center report in Cell.

14 Nov 2019

Scientists explore expansion of cytotoxic CD4 T-cells in supercentenarians

Scientists from the RIKEN Center for Integrative Medical Science (IMS) and Keio University School of Medicine in Japan have used single-cell RNA analysis to find that supercentenarians--meaning people over the age of 110--have an excess of a type of immune cell called cytotoxic CD4 T-cells.

13 Nov 2019

Improved gene editing technique can successfully cut out undesirable genetic information

City of Hope researchers may have found a way to sharpen the fastest, cheapest and most accurate gene editing technique, CRISPR-Cas9, so that it can more successfully cut out undesirable genetic information.

7 Nov 2019

Potential new target identified to treat inflammatory disease

Researchers led by the University of Birmingham have found a potential new target to treat inflammatory disease.

7 Nov 2019

New model could predict response of HIV-infected individuals to cancer immunotherapy

A group of researchers at UPF and the Marchuk Institute of Numerical Mathematics in Moscow, Russia, have designed a mathematical model to predict the response of HIV-infected individuals to a type of cancer immunotherapy.

7 Nov 2019

Medical and socioeconomic factors may hinder employability of people with HIV/AIDS

People living with HIV/AIDS may face discrimination in employers' hiring practices. A study published in the American Journal of Industrial Medicine found that medical and socioeconomic factors may hinder their employment.

6 Nov 2019

Correlates of HIV risk associated with decrease in disease transmission, study confirms

Immune responses that are associated with a decreased risk of infection are called correlates of protection.

1 Nov 2019

New cellular immunotherapy for cancers

A new study published in the journal Nature Communications on 22 October 2019 reports a new approach to cancer treatment that increases the immune capability of T lymphocytes against malignant cancers. This allows the T cells to successfully infiltrate and destroy these tumors. Animal trials have been completed and the researchers are planning clinical trials in human beings next.

26 Oct 2019

Study finds molecular key to formation of mature and fully functioning T cells

In a finding that could help lead to new therapies for immune diseases like multiple sclerosis and IBD, scientists report in the Journal of Experimental Medicine identifying a gene and family of proteins critical to the formation of mature and fully functioning T cells in the immune system.

25 Oct 2019

ConvertibleCAR immunotherapy can be used to attack HIV latent reservoir

A team of Gladstone scientists and their partners at Xyphos Biosciences, Inc. describe a new way of attacking cells infected by HIV in this week's issue of the journal Cell.

24 Oct 2019

Researchers assess accuracy of lateral flow urine LAM test in detecting TB in HIV-positive people

Tuberculosis (TB) causes more deaths in people living with HIV than any other disease, with more than 300,000 deaths in 2017. When detected, early TB can be treated effectively; however, people with advanced HIV are at high risk of death, often without knowing they have TB.

22 Oct 2019

Scientists find new evidence on latent HIV reservoir

Antiretroviral therapy (ART) can suppress HIV to the point where the virus is nearly undetectable, and people on medication can live many years.

10 Oct 2019

Initial use of ART alters host environment to allow formation of long-lived HIV reservoir

Antiretroviral therapy (ART) can suppress HIV to the point where the virus is nearly undetectable, and people on medication can live many years. But therapy cannot completely eradicate the virus; it persists in reservoirs inside immune cells, a phenomenon called "latency."

9 Oct 2019

HIV-1 Tat expression leads to perturbations in cellular protein expression, research suggests

The cover for issue 54 of Oncotarget features Figure 2, "Comparative proteomic profiling of the peptides/proteins identified from 293T, IL16lamp2b and mExo-Tat samples," by Lu, et al.

4 Oct 2019

CAR T-cell therapy may be effective in killing solid tumor cells

There is now a multitude of therapies to treat cancer, from chemotherapy and radiation to immunotherapy and small molecule inhibitors. Chemotherapy is still the most widely used cancer treatment, but chemotherapy attacks all the rapidly dividing cells that it locates within the body, whether they're ultimately harmful or beneficial.

2 Oct 2019

New study shows response to HIV vaccine in 6 weeks

A US study on DNA-based and protein HIV vaccines has shown that an antibody and cellular immune response occurs within six weeks.

2 Oct 2019

New study shows response to HIV vaccine in 6 weeks

A new study using DNA-based and protein HIV vaccines in various combinations shows that antibody and cellular immune response occurs within 6 weeks from the date of vaccination, and the combination must be administered together for the most rapid protection. This will enable more large-scale testing of the vaccine for effectiveness. About 40 million people today have HIV infections, and 1.2 million deaths a year are related to this infection.

1 Oct 2019

Cancer Research Institute declares 2019 recipients of top scientific and philanthropic awards

The Cancer Research Institute (CRI), a nonprofit organization dedicated to advancing the discovery and development of powerful immunotherapies for all forms of cancer, has announced the 2019 recipients of its highest scientific and philanthropic awards.

27 Sep 2019

Adding radiation after immunotherapy increases PFS for some patients with metastatic NSCLC

Adding precisely aimed, escalated doses of radiation after patients no longer respond to immunotherapy reinvigorates the immune system in some patients with metastatic non-small-cell lung cancer, increasing progression-free survival.

26 Sep 2019

CD4 News and Research

HIV-exposed but uninfected individuals at risk of obesity and asthma-like symptoms

Research explains why immunotherapy fails against prostate cancer bone metastases

Scientists explore expansion of cytotoxic CD4 T-cells in supercentenarians

Improved gene editing technique can successfully cut out undesirable genetic information

Potential new target identified to treat inflammatory disease

New model could predict response of HIV-infected individuals to cancer immunotherapy

Medical and socioeconomic factors may hinder employability of people with HIV/AIDS

Correlates of HIV risk associated with decrease in disease transmission, study confirms

New cellular immunotherapy for cancers

Study finds molecular key to formation of mature and fully functioning T cells

ConvertibleCAR immunotherapy can be used to attack HIV latent reservoir

Researchers assess accuracy of lateral flow urine LAM test in detecting TB in HIV-positive people

Scientists find new evidence on latent HIV reservoir

Initial use of ART alters host environment to allow formation of long-lived HIV reservoir

HIV-1 Tat expression leads to perturbations in cellular protein expression, research suggests

CAR T-cell therapy may be effective in killing solid tumor cells

New study shows response to HIV vaccine in 6 weeks

New study shows response to HIV vaccine in 6 weeks

Cancer Research Institute declares 2019 recipients of top scientific and philanthropic awards

Adding radiation after immunotherapy increases PFS for some patients with metastatic NSCLC

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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