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Novel HIV vaccine shows promise

There are millions living with HIV and researchers have been working towards making a successful vaccine against the deadly infection for the past 35 years with no success. Now a new blueprint is being developed to prevent the infection.

15 Dec 2019

NIH-funded research finds differences in energy use by immune T cells in ME/CFS

New findings published in the Journal of Clinical Investigation suggest that specific immune T cells from people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) show disruptions in the way they produce energy.

12 Dec 2019

New approach to broadly acting, highly effective HIV vaccine

Researchers have reported a major advance in the creation of a successful HIV vaccine that is not produced by the host animal.

9 Dec 2019

Transitional T cells could help improve cancer immunotherapy

In chronic viral infections and cancer, T cell dysfunction is sure to be observed. A new study to be published in the journal Immunity shows that before these cells are completely exhausted, there is a transitory stage in which some cells are present with features that are characteristic of neither the stem-like T cells nor the mature but exhausted T cells.

4 Dec 2019

Expansion of HIV treatment eligibility leads to large increase in ART initiation among youth

A new study published as "Editor's Choice" in The Journal of Infectious Diseases found that expansion of HIV treatment eligibility to include those under age 15 led to large and significant increases in initiation of antiretroviral therapy within 30 days of enrollment in care among 10- to 14-year-olds living with HIV.

3 Dec 2019

Study: TBK1 protein promotes cancer development, suppresses immune response to the disease

Researchers at The University of Texas MD Anderson Cancer Center have found that a protein involved in immune response to microbes also can fuel cancer development and suppress immune response to the disease.

3 Dec 2019

Study: Spleen and gut lymph nodes may serve as reservoir replication sites for HIV virus

An international team led by Professor Jerome Estaquier from Universite Laval's Faculty of Medicine and the CHU de Quebec-Universite Laval Research Center may have discovered where in the body HIV takes refuge during antiretroviral treatment.

3 Dec 2019

Many women in Europe are diagnosed at late stage of HIV infection

Many women in the WHO European Region, particularly those in their 40s, are diagnosed at a late stage of HIV infection when their immune system is already starting to fail. They are three to four times more likely to be diagnosed late than younger women.

28 Nov 2019

Experimental vaccine elicits antibodies that can neutralize multiple HIV strains

An experimental HIV vaccine developed by scientists at Scripps Research and the nonprofit vaccine research organization IAVI has reached an important milestone by eliciting antibodies that can neutralize a wide variety of HIV strains.

21 Nov 2019

Dopamine may worsen lung inflammation in asthma

A new study on a mouse model of asthma shows that nerve cells producing dopamine, a neurotransmitter, signal T cells in the body to promote inflammation due to allergic reactions in the lungs during childhood but not in adult mice.

19 Nov 2019

HIV-exposed but uninfected individuals at risk of obesity and asthma-like symptoms

Adolescents and young adults who were born to mothers with HIV but remained uninfected themselves still face a greatly heightened risk of obesity and asthma-like symptoms, researchers from Massachusetts General Hospital have found.

15 Nov 2019

Research explains why immunotherapy fails against prostate cancer bone metastases

Prostate cancer that spreads to the bone triggers the destruction of bone tissue that, in turn, thwarts the effectiveness of immune checkpoint inhibitors by blocking the development of T cells that are crucial to successful treatment, researchers from The University of Texas MD Anderson Cancer Center report in Cell.

14 Nov 2019

Scientists explore expansion of cytotoxic CD4 T-cells in supercentenarians

Scientists from the RIKEN Center for Integrative Medical Science (IMS) and Keio University School of Medicine in Japan have used single-cell RNA analysis to find that supercentenarians--meaning people over the age of 110--have an excess of a type of immune cell called cytotoxic CD4 T-cells.

13 Nov 2019

Improved gene editing technique can successfully cut out undesirable genetic information

City of Hope researchers may have found a way to sharpen the fastest, cheapest and most accurate gene editing technique, CRISPR-Cas9, so that it can more successfully cut out undesirable genetic information.

7 Nov 2019

Potential new target identified to treat inflammatory disease

Researchers led by the University of Birmingham have found a potential new target to treat inflammatory disease.

7 Nov 2019

New model could predict response of HIV-infected individuals to cancer immunotherapy

A group of researchers at UPF and the Marchuk Institute of Numerical Mathematics in Moscow, Russia, have designed a mathematical model to predict the response of HIV-infected individuals to a type of cancer immunotherapy.

7 Nov 2019

Medical and socioeconomic factors may hinder employability of people with HIV/AIDS

People living with HIV/AIDS may face discrimination in employers' hiring practices. A study published in the American Journal of Industrial Medicine found that medical and socioeconomic factors may hinder their employment.

6 Nov 2019

Correlates of HIV risk associated with decrease in disease transmission, study confirms

Immune responses that are associated with a decreased risk of infection are called correlates of protection.

1 Nov 2019

New cellular immunotherapy for cancers

A new study published in the journal Nature Communications on 22 October 2019 reports a new approach to cancer treatment that increases the immune capability of T lymphocytes against malignant cancers. This allows the T cells to successfully infiltrate and destroy these tumors. Animal trials have been completed and the researchers are planning clinical trials in human beings next.

26 Oct 2019

Study finds molecular key to formation of mature and fully functioning T cells

In a finding that could help lead to new therapies for immune diseases like multiple sclerosis and IBD, scientists report in the Journal of Experimental Medicine identifying a gene and family of proteins critical to the formation of mature and fully functioning T cells in the immune system.

25 Oct 2019

CD4 News and Research

Novel HIV vaccine shows promise

NIH-funded research finds differences in energy use by immune T cells in ME/CFS

New approach to broadly acting, highly effective HIV vaccine

Transitional T cells could help improve cancer immunotherapy

Expansion of HIV treatment eligibility leads to large increase in ART initiation among youth

Study: TBK1 protein promotes cancer development, suppresses immune response to the disease

Study: Spleen and gut lymph nodes may serve as reservoir replication sites for HIV virus

Many women in Europe are diagnosed at late stage of HIV infection

Experimental vaccine elicits antibodies that can neutralize multiple HIV strains

Dopamine may worsen lung inflammation in asthma

HIV-exposed but uninfected individuals at risk of obesity and asthma-like symptoms

Research explains why immunotherapy fails against prostate cancer bone metastases

Scientists explore expansion of cytotoxic CD4 T-cells in supercentenarians

Improved gene editing technique can successfully cut out undesirable genetic information

Potential new target identified to treat inflammatory disease

New model could predict response of HIV-infected individuals to cancer immunotherapy

Medical and socioeconomic factors may hinder employability of people with HIV/AIDS

Correlates of HIV risk associated with decrease in disease transmission, study confirms

New cellular immunotherapy for cancers

Study finds molecular key to formation of mature and fully functioning T cells

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