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Network of proteins linked to cancer may play vital role in male fertility

Researchers studying reproductive science identified a network of proteins often linked to cancer as also important to male fertility and the birth of healthy offspring, according to a study in the Oct. 18 online issue of Cell Reports.

19 Oct 2016

NAC improves effectiveness of adoptive cell therapy for treating melanoma

A collaborative team of investigators at the Medical University of South Carolina and Loyola University have demonstrated for the first time that culturing T cells in N-acetyl cysteine (NAC) before they are infused as immunotherapy improves effectiveness and outcomes in a preclinical model of melanoma. These findings were reported in the October 15, 2016 issue of Cancer Research.

17 Oct 2016

UT Southwestern researchers discover protein that leads to brain cell death during stroke

One particular protein is the final executioner of events that result in the death of brain cells during stroke, researchers from UT Southwestern Medical Center and their collaborators report. This finding could ultimately lead to new ways to protect against brain damage.

7 Oct 2016

Study explores antimicrobial and antiinflammatory activities of bovine colostrum

Colostrum is a thick, sticky, yellowish mammary secretion that all mammals provide to their newborns during the first 24-48 hours after delivery.

7 Oct 2016

Treatment using PARP inhibitor shrinks tumors in breast cancer patients with BRCA mutations

All 13 newly diagnosed breast cancer patients with BRCA mutations had their tumors shrink significantly when treated with a PARP inhibitor ahead of frontline presurgical chemotherapy in a pilot study at The University of Texas MD Anderson Cancer Center.

5 Oct 2016

Scientists discover new switch that coordinates DNA repair and cell death

The genetic information of every cell is encoded in the sequence of the DNA double helix. Double strand breaks in the DNA, which can be induced by radiation, are a dangerous threat to the cells, and if not properly repaired can lead to cancer.

28 Sep 2016

Approval of PD-1 inhibitor scratches surface of potential immunotherapies in recurrent HNSCC

The recent approval of pembrolizumab (Keytruda) in recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) following progression on a platinum-based chemotherapy was a significant advancement for the disease.

26 Sep 2016

DNA damage caused by smoking may last a lifetime

Results of a study published this week show that the effects of smoking on DNA are wide-reaching and some persist long after a person has stopped smoking. The information gained may help improve our understanding of smoking-related diseases.

23 Sep 2016

Tumour suppressor gene has greater anti-cancer activity than previously thought

New insight into the function of a gene important in the suppression of cancer is published today. Researchers at the National University of Ireland Galway have shown that the TP53 gene has even greater anti-cancer activity than previously thought.

22 Sep 2016

Researchers identify genes that regulate cellular senescence

A research group including Professor KAMADA Shinji, Research Fellow NAGANO Taiki (both from the Kobe University Biosignal Research Center), and Unit Chief ENARI Masato (National Cancer Research Institute) has succeeded in identifying genes that control cellular senescence - permanently arrested cell growth.

13 Sep 2016

Genome-wide studies reveal evolutionary conserved enzyme facilitates DNA replication

Genome-wide studies of fission yeast (Schizosaccharomyces pombe) suggest that the evolutionary conserved enzyme Pfh1 helicase facilitates DNA synthesis by tracking along with the replication apparatus, promoting intact DNA synthesis at hard-to-replicate sites and consequently suppressing DNA damage. The findings are published in PLOS Genetics.

12 Sep 2016

Researchers identify how ionising radiation can cause cancer by damaging DNA

For the first time, researchers from the Wellcome Trust Sanger Institute and their collaborators have been able to identify in human cancers two characteristic patterns of DNA damage caused by ionising radiation.

12 Sep 2016

Researchers uncover molecular differences between African and Asian strain of Zika virus infections

Scientists have revealed molecular differences between how the African and Asian strains of Zika virus infect neural progenitor cells.

1 Sep 2016

Research findings could lead to new biomarker for early stages of tumor development

To treat or not to treat? That is the question researchers at the Department of Energy's Lawrence Berkeley National Laboratory hope to answer with a new advance that could help doctors and their cancer patients decide if a particular therapy would be worth pursuing.

31 Aug 2016

DNA Damage News and Research

Network of proteins linked to cancer may play vital role in male fertility

NAC improves effectiveness of adoptive cell therapy for treating melanoma

UT Southwestern researchers discover protein that leads to brain cell death during stroke

Study explores antimicrobial and antiinflammatory activities of bovine colostrum

Treatment using PARP inhibitor shrinks tumors in breast cancer patients with BRCA mutations

Scientists discover new switch that coordinates DNA repair and cell death

Approval of PD-1 inhibitor scratches surface of potential immunotherapies in recurrent HNSCC

DNA damage caused by smoking may last a lifetime

Tumour suppressor gene has greater anti-cancer activity than previously thought

Researchers identify genes that regulate cellular senescence

Genome-wide studies reveal evolutionary conserved enzyme facilitates DNA replication

Researchers identify how ionising radiation can cause cancer by damaging DNA

Researchers uncover molecular differences between African and Asian strain of Zika virus infections

Research findings could lead to new biomarker for early stages of tumor development

Advanced imaging technique could help select embryos most viable for successful pregnancy

Seeds of tropical shrub guarana contain ten times more amount of catechins than green tea

Penn study sheds light on role of essential compound in maintaining optimal muscle function

Study reveals unexpected process for acquiring chemoresistance in breast cancers

New study sheds light on pathogenesis of DNA lesions present in leukemia

CNIO study shows proinflammatory molecule IL-17A can be key factor in development of NASH and HCC

Understanding the DNA Damage Response in Innate Immunity eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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